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Silent Valley Consulting – open for business

Life sciences marketing consulting for technical writing, content marketing, strategy and market research Several years ago during the publishing of the book about COVID-19 diagnostics, therapeutics and vaccines (“Chaos to Cure”), I registered a business with the state of Maryland called Silent Valley Incorporated. Recently with a change in my […]


Proteomics in Proximity: Co-Hosting a New Podcast

Do you listen to podcasts? Would you be interested in learning about how Olink Proteomics’ technology is applied in biomarker discovery, drug discovery, proteogenomics, and routine research into biological mechanisms? If so, here’s the first ‘teaser’ advertisement, and we will be launching the first episode in a week. You can […]


Discovery of a novel mechanism unique to severe COVID leads to a potential treatment

In a large meta-analysis, circulating protein levels of severe COVID patients along with many thousands of genomic datasets leads to an exciting discovery: a mutation in a gene called FAS that turns it into a non-membrane-bound, soluble form, interrupting normal immune function. In addition, an on-market chemotherapeutic drug has been […]


A 2022 NGS Cost and Throughput Comparison

With Singular Genomics announcing the new G4 system at the end of 2021, and Element Biosciences announcing the AVITI system in March 2022, here is a look at the existing state-of-the-art systems in a single graphic After spending some time in Los Angeles this week visiting a few existing and […]

Cost and Throughput calculations for NGS systems

Element Biosciences AVITI™ Sequencing System

A new approach to next-generation sequencing, a little-known company unwraps an instrument that competes directly with the Illumina NextSeq 2000 with a third more of the throughput at half the consumables price For a technology that started in 2005 with the first 454 / Roche FLX next-generation sequencing (NGS) platform, […]


Milestones of the UK Biobank

The UK Biobank – a veritable fountain of discovery

With a robust collection of 500,000 individuals, the UK Biobank will succeed in its mission to study the determinants of disease through genetics and proteomics combined with extensive electronic health records and ongoing assessments What the UK Biobank is and its current status The UK Biobank (abbreviated UKB or UKBB) […]


Single-cell interaction technology from Scribe Biosciences 1

Promising technology out of UCSF to use droplets as containers for single-cell interaction assays Way back in 2009 I remember the first time my sales manager at RainDance Technologies presented their core technology to a sophisticated group at the US National Institutes of Health, with an introduction to microfluidics. He […]

Scribe Biosciences' microenvironment on demand technology

Olink Signature Q100 benchtop instrument for proteomics

A new proteomic instrument: The Olink Signature Q100

An economical and scalable benchtop instrument bringing multiplex protein assays to individual laboratories or centralized core facilities The Olink original offering: 96-plex on the Fluidigm Biomark Olink started its commercial laboratory in the Boston area in 2016, based upon the Proximity Extension Assay technology and method published in a 2014 […]


New role at Olink Proteomics

For those of you who have followed my work over the years, I’m happy to report that I start with Olink Proteomics as their new Director of Field Marketing for the Americas today (February 2021). It may come as a surprise to many of you steeped in genomics that I’d […]

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DxTerity saliva sample collection

DxTerity COVID-19 saliva test for home or employer collection

A direct-to-consumer COVID-19 test available via Amazon with a convenient saliva sample-type and fast central-laboratory processing The current environment for this third (or is it fourth) wave of COVID-19 SARS-CoV-2 infections is reaching new records. The first week of January 2021 is seeing a 7-day moving average of cases above […]