What being unemployed taught me 1

“Keep working no matter what happens If things are good, keep working. If things are bad, keep working.” Moby (American singer-songwriter) I am happy to say that my stint of being in-between employers has come to an end. (Details will be forthcoming.) I’d like to say now (in that period […]

One door closes, another one will open

A two-year stint at SeraCare comes to an end A little over two years ago I wrote a post called ‘One door opens, and another door closes’ about my moving from Life Technologies / Thermo Fisher Scientific over to a small in-vitro diagnostic controls and reference material company SeraCare Life Sciences. […]

Cancer immunotherapy combination trials and a failure of the free market

What happens when commercial interests do not align? Over a decade ago in 2002 when Novartis announced it was moving its global headquarters to Boston MA, it was viewed at the time that the United State’s pharmaceutical market was the most robust and attractive, and it made sense for Novartis […]

PD-L1 Immunotherapy

Cancer immunotherapy and a clinical trial dilemma

There is a numbers problem, and a biomarker one as well. Annually the worldwide cancer drug market is on the order of $110 Billion, and individual immuno-oncology drugs cost the US healthcare system on the order of $100K to $150K per year. With such large financial incentives, there are currently over 900 […]

The immune system and cancer immunotherapy

A ‘gold rush’ multi-billion dollar business, three targets, four cancer drugs, four antibody-based companion diagnostic tests, sixteen FDA approvals The human immune system is remarkable. When you think about the preponderance of death by infectious disease throughout history, the top two causes of death in 1900 was influenza and pneumonia, […]

Exponential technologies and electronic DNA detection

We are living in a world of exponential technologies, and genomics is one of several where expectations are not set at something 30% better or cheaper or faster, but 300% within the space of a few years. The term ‘exponential’ is starting to gain traction in the general public; here […]

Biological Dynamics – An Electronic cfDNA Detection Platform

While at the CHI Molecular Tri-Conference a few weeks ago, you can learn first-hand what you may have heard in passing but due to constraints of time had not had the chance to look into more deeply. Biological Dynamics is one such company; a colleague at SeraCare told me briefly […]

A handheld single-molecule diagnostic platform Two Pore Guys

One of the long-held goals for molecular testing of any sort (from testing the food supply for food-borne illness, to livestock health, to forensic testing, to testing for infectious disease, to screening for cancer) is to obtain inexpensive results without a lot of expensive equipment. The latest effort at ‘point-of-care’ […]