Bionano Genomics’ New DLS Saphyr Technology at #AGBT18

It has been almost five years since I wrote this post about Bionano Genomics and OpGen, and tools to look at structural variation. At that time OpGen was mapping bacterial genomes and Bionano Genomics would do insect genomes (about 100x as large), and the open question at that time was […]


Illumina’s iSeq 100 at #AGBT18 2

During the flurry of activity at the recent Advances in Genome Biology and Technology, I made it a point to take a close look at the newest CMOS-based NGS instrument from Illumina, called the iSeq 100. And it’s a good time to get a little perspective where next-generation sequencing has […]


NanoString’s Hyb & Seq Single Molecule Sequencer at #AGBT18

Background Back in 1989 in Belgrade Yugoslavia, Radoje Drmanac had an idea that would shape the next decade of genetic analysis, which was being able to sequence megabases of DNA information by a collection of 11-mers to 20-mers. Doing the mathematical calculations, this paper lays out what kind of DNA […]


NanoString’s Digital Spatial Profiling Microscope at #AGBT18

Now that another year has passed it is great to see the NanoString Digital Spatial profiling microscope near its commercial launch. The platform will be in early access to select customers in the fourth quarter of 2018, and full commercial launch in the first half of 2019. For those interested […]


Ion GeneStudio S5: The latest iteration of Thermo Fisher Scientific NGS 1

With the beginning of the influential JP Morgan Healthcare investor conference this week in San Francisco, you can expect an avalanche of news from companies large and small regarding all things therapuetic and diagnostic. With an official count of about 9,000 attendees, there are many more in San Francisco who […]


Thoughts from the Association of Molecular Pathology conference #AMP2017

John Iafrede (Massachusetts General Hospital, MA) “There is a tidal wave of cell-free approaches; little performance testing; and the big question is who is going to pay for it.” This year’s Assocation for Molecular Pathology was held in Salt Lake City, Utah from November 15-18, 2017. (You can find the […]

#AMP2017

Pillar Biosciences at Association for Molecular Pathology #AMP2017

While at the Association for Molecular Pathology in Salt Lake City Utah, I was able to interview Gang Song CEO of Pillar Biosciences to ask him about the challenges in the clinical laboratory that Pillar is tackling, about the basics of SLIMamp technology, and recent news. Check it out! #AMP2017