April 22, 2013
by Dale Yuzuki
5 Comments
Earlier this year at the February AGBT Conference, a person from QIAGEN came over to the Ion Torrent suite and asked me a few questions about the Ion Proton and in particular the upcoming Ion Chef unit. (The Ion Chef … Continue reading
August 2, 2012
by Dale Yuzuki
3 Comments
Every mother-to-be who has what is considered an ‘at-risk’ pregnancy is informed of the risks to the fetus of a genetic abnormality. ‘At-risk’ can involve a long list of medical conditions (diabetes or cancer for example) or poor health choices … Continue reading
July 30, 2012
by Dale Yuzuki
2 Comments
Immunology is a fascinating subject. Immense in its complexity, debilitating when the immune system malfunctions, our ability to fend off bacterial and viral infection, cancers of different types, and other foreign invaders is a remarkable biological capability. The NIH estimates … Continue reading
July 14, 2012
by Dale Yuzuki
2 Comments
This week a remarkable paper was published in Nature, called “Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells”. What makes it remarkable is the ability of this method to obtain rare variant phase information by changing the … Continue reading
July 11, 2012
by Dale Yuzuki
2 Comments
Although the whole genome versus whole exome discussion was held previously, details around the methods of selecting out the whole exome have been not discussed (also called ‘targeted selection’), and the wide array of methods, costs, and effort required can … Continue reading
July 5, 2012
by Dale Yuzuki
0 comments
The myth of the complete genome is something that is not commonly known to active observers of genomic technologies. (The term ‘active observer’ is from the point of view of one with varying degrees of background in the biological sciences, … Continue reading
July 2, 2012
by Dale Yuzuki
0 comments
Oxford Nanopore, based in Oxford U.K., made a remarkable announcement that surprised many in February’s AGBT meeting in Marco Island. A GridION and MiniION single-molecule sequencers were announced, promising 15 minute runtimes, no sample preparation, and a disposable USB-stick sequencer … Continue reading
June 27, 2012
by Dale Yuzuki
4 Comments
Recently I was asked what Roche would purchase when they said publicly that they “would not revisit Illumina, and will pursue smaller takeovers”, and I answered there were a few small development companies out there but even fewer with something … Continue reading
June 25, 2012
by Dale Yuzuki
8 Comments
The next-generation sequencing market continues its downward trajectory – routinely violating Moore’s Law by an estimated 3x, the cost per megabase curve started to significantly bend downward around 2007 when the Solexa 1G started selling in volume, and gave the … Continue reading
June 21, 2012
by Dale Yuzuki
0 comments
In every technological revolution, there is a first seminal breakthrough, a burst of commercial activity from many individual companies, and then the eventual maturing of a market, of standards, and the discovery of new uses for the technology in often … Continue reading