Landi: Wanted to related SNPs to CpGs, a methylation QTL (meQTL). And is it tissue-specific? http://t.co/WPQVqNryhl #ncistg14

1:50pm March 20th 2014 via Twitter Web Client

Maria Teresa Landi, NCI DCEG. “Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue” #ncistg14

1:46pm March 20th 2014 via Twitter Web Client

McCormick: KRAS can 'promote a program to make cells more stem-like'. LIF identified as making KRAS tumors more stem-like #ncistg14

1:34pm March 20th 2014 via Twitter Web Client

McCormick: Back to KRAS importance over HRAS. KRAS could be more potent, or higher-level of expression control (large mut. target) #ncistg14

1:33pm March 20th 2014 via Twitter Web Client

McCormick: M-Ras (R-Ras3) cooperates with KRAS to activate Raf kinase. http://t.co/9ZpkoyO0Xi #ncistg14

1:29pm March 20th 2014 via Twitter Web Client

McCormick: Can force dimerization and show signaling, but all mutant forms required for full activation (pair of dimers) #ncistg14

1:27pm March 20th 2014 via Twitter Web Client

McCormick: Suggests that Ras exists as a dimeric state. Single protein visualized at the membrane - dimers seen #ncistg14

1:25pm March 20th 2014 via Twitter Web Client

McCormick: Described Legius syndrome, no NF1 mutation but activated RAS. NF1 binds to SPRED1, recruits NF1 to RAS #ncistg14

1:20pm March 20th 2014 via Twitter Web Client

McCormick: Gly12 to Val12 'steric clash' prevented targeting of that interface (drug dev. perspective). NCI will be targeting now #ncistg14

1:19pm March 20th 2014 via Twitter Web Client

McCormick: How GAP protein binds, 3D structure, Arg finger binds http://t.co/2mJ1Bv8RMD #ncistg14

1:17pm March 20th 2014 via Twitter Web Client

McCormick: After p53 and PTEN, NF1 the third-most mutated in cancer. Infrequent overlap with other drivers acc to TCGA #ncistg14

1:15pm March 20th 2014 via Twitter Web Client

McCormick: NF1 difficult to work with, 2818a (human), also somatic mut's in COSMIC, TCGA data also indicative of NF1 loss #ncistg14

1:14pm March 20th 2014 via Twitter Web Client

McCormick: NF1 neurofibromatosis encodes GAP related protein, interacts with Ras (1990) NF1 disease of hyperactive ras #ncistg14

1:12pm March 20th 2014 via Twitter Web Client

McCormick: Reviewed the Ras pathway, GAPs bind but get stuck in GTP state. WT proteins can also contribute #ncistg14

1:09pm March 20th 2014 via Twitter Web Client

#NCI Symposium on Translational Genomics: Keynote Address: Frank McCormick, UCSF "New approaches to targeting RAS" #ncistg14

1:00pm March 20th 2014 via Twitter Web Client

Liu: From blots, to equations, to his own 'hairball' of data #ncistg14

12:54pm March 20th 2014 via Twitter Web Client

Liu: And cancer as a systems engineering problem. Illustrated how his publications have changed over the years #ncistg14

12:54pm March 20th 2014 via Twitter Web Client

Liu: Many oncologic elements acting together: massive combinatorics, some with synthetic phenotypes #ncistg14

12:53pm March 20th 2014 via Twitter Web Client

Liu: The challenge - cancer as an evolutionary process, simult. genetic solutions to survival of a cancer cell #ncistg14

12:52pm March 20th 2014 via Twitter Web Client

Liu: Used a term 'enhance-osome' - as the three factors working together for ER function. http://t.co/gsWMIfewgu #ncistg14

12:49pm March 20th 2014 via Twitter Web Client

Liu: Using ChIP-Seq, looked at 3 xcr factors all binding (ER-a, FOXA1, GATA3), all within 200bp #ncistg14

12:48pm March 20th 2014 via Twitter Web Client

Liu: Estrogen receptor & br cancer: but if ER transfected into ER-neg cells, why negative growth? Did xcr factor combinatorics #ncistg14

12:46pm March 20th 2014 via Twitter Web Client

Liu: Idea: driver mut's, plus 'backseat driver' mut's driving cancer. #ncistg14

12:44pm March 20th 2014 via Twitter Web Client

Liu: MH3 mimetics overcome erlotinib resistance in cell with 2.9delta BIM allele, currently in trials #ncistg14

12:44pm March 20th 2014 via Twitter Web Client

Third Symposium on Translational Genomics - Agenda http://t.co/fWXBbCcpkm #ncistg14

12:43pm March 20th 2014 via Hootsuite

Liu: Looking at CML and intrinsic response rate to imatinib is only ~75% in Asia. Describes BIM gene 2.9kb del. 12% Asian 0% Cauc #ncistg14

12:42pm March 20th 2014 via Twitter Web Client

Liu: ERBB2 by itself, antagonistic. But targeting other genes on Chr17q via siRNA, it is not additive but synergistic #ncistg14

12:38pm March 20th 2014 via Twitter Web Client

Liu: "Chromosomal origami to generate a cancer gene growth cassette" - are there synergies, non-additive effects? #ncistg14

12:37pm March 20th 2014 via Twitter Web Client

Liu: Listed ~20 17q21 genes, tested in br cancer cell lines as a growth driver, an 'origami' model #ncistg14

12:35pm March 20th 2014 via Twitter Web Client

Liu: PolII and xcr factors pull DNA into genomic loops; structural mut's should be in regions with PolII marks. Grzeda (submitted) #ncistg14

12:33pm March 20th 2014 via Twitter Web Client

Liu's opening talk "Systems Biology in cancer - importance of combinatorics" #ncistg14

12:32pm March 20th 2014 via Twitter Web Client

Ed Liu, Jackson Laboratory, at the NCI Translational Genomics Symposium #ncistg14 http://t.co/yyh3DbHr8P

12:28pm March 20th 2014 via Hootsuite