Asymptomatic Transmission: The Achilles’ Heel

Research from a Washington State skilled nursing facility confirms over half did not show symptoms but are infecting others with SARS-CoV-2 In early March, this report in JAMA (Journal of the American Medical Association) was the first outside-of-China, peer-reviewed publication that documents asymptomatic spread. In brief: an otherwise healthy Shanghai […]

rRT-PCR and Seroconversion of SARS-CoV-2 in Nine COVID-19 patients 1

Thorough research on nine infected individuals in Germany shows important details on the natural course of SARS-CoV-2 infection, infectivity from an infected individual, and ability to detect the RNA via rRT-PCR, live virus assay, and neutralizing antibody testing It was about five years ago, starting at a new employer SeraCare […]

Immunofluorescence of neutralizing antibody against SARS-CoV-2 spike protein

Notes about asymptomatic spread of SARS-CoV-2

You will need to wear a mask for a while In this current worldwide COVID-19 pandemic, the head of the US Nursing Home Association has rightly called the SARS-CoV-2 virus ‘almost the perfect killing machine‘ for elderly patients. Compared to SARS-CoV (aka ‘SARS Classic’ circa 2003), it is clear that […]

NIH starts serological survey testing anti-SARS-CoV-2 among the US population 2

Using both traditional blood draw and an innovative home-collection device, the NIH recruits 1000 healthy volunteers nationwide The SARS-CoV-2 virus (otherwise known as coronavirus, the causative virus of COVID-19 disease currently rampaging worldwide) is a difficult pathogen to battle. While clearing out my bursting-at-the-seams ‘downloads’ folder on my computer this […]

Serological testing in Germany shows resistance to coronavirus SARS-CoV-2 at 14 percent 3

First preliminary results from widespread IgA/IgG SARS-CoV-2 resistance antibody testing in Heinsberg Germany Being an active research scientist or having a life science research background during a once-in-a-lifetime worldwide epidemic is a remarkable thing. Whether reading pre-prints on MedRxiv or looking into the latest news of the day or reading […]

German Karneval goer ready to party

The first antibody test for SARS-CoV-2 in the US 1

The US FDA clears the first serology test for assessing infectious spread In many ways it is difficult to assess the passage of time while in a national shutdown. It was a little over a week ago that I wrote about the need for a good antibody test for SARS-CoV-2, […]

Reasons for SARS-CoV-2 optimism and a COVID-19 infographic

There is some reason in the US for optimism in the middle of this SARS-CoV-2 pandemic. I wrote earlier this week the absolute need for an antibody-based test for widespread public screening, to assess antibody responses to get a picture of who has been exposed to the virus and has […]

Am I infected?

A list of helpful SARS-CoV-2 and COVID-19 links 1

An organized resource list to check out Keeping track of the outbreak Coronavirus Tracked by the Financial Times. The source of those cool ‘Number of days since 10th death’ by country (to get a comparative picture of doubling rates, points at which lockdowns were initiated) as well as a table […]

The need for a good antibody test for SARS-CoV-2 2

The FDA will release under EUA a good antibody test, but time is of the essence to get decent tracking and tracing in-place Without adequate testing for SARS-CoV-2, the novel coronavirus that is now sweeping rapidly around the world, there can be no isolation of cases and the chain of […]

A hopeful cure for SARS-CoV-2 with a combination of drugs

If the combination of hydroxychloroquine and azithromycin is confirmed by larger studies this actually could be “one of the biggest game-changers in the history of medicine” During this worldwide COVID-19 pandemic, now that states such as California and New York have enacted ‘stay at home’ orders, universities and many school […]