Two Pore Guys single-molecule diagnostic platform update

Two Pore Guys (2PG) has come a long way in a little over 18 months Background of Two Pore Guys At the recent Next Generation Diagnostics Conference in Washington DC (#NGDx18) Two Pore Guys had a nice exhibit where I had the privilege of meeting Tyler Shropshire Ph.D., their Sr. […]

Two Pore Guys Artist Rendition, kindly provided by 2PG

Google Artificial Intelligence for Pathology

Observations from American Association for Cancer Research 2018 #AACR18

It is something of a tradition for me to give some reviews of notable presentations from past AACR conferences. For example, here’s one that I did while at SeraCare for #AACR16, here’s one from #AACR15, and another one here from #AACR14. (Briefly looking for highlights from 2017, well it looks like […]


Learning content marketing and The Pillar Post

The world of content marketing is an ever-changing experience. A bit of history A few years ago it was a full-time effort to conduct video interviews, write blog posts, and help the sales team in other ways at Thermo Fisher Scientific’s Genetic Systems Division. (You can see some of that […]

The Pillar Post Pillar Biosciences

Bionano Genomics’ New DLS Saphyr Technology at #AGBT18

It has been almost five years since I wrote this post about Bionano Genomics and OpGen, and tools to look at structural variation. At that time OpGen was mapping bacterial genomes and Bionano Genomics would do insect genomes (about 100x as large), and the open question at that time was […]


Illumina’s iSeq 100 at #AGBT18 2

During the flurry of activity at the recent Advances in Genome Biology and Technology, I made it a point to take a close look at the newest CMOS-based NGS instrument from Illumina, called the iSeq 100. And it’s a good time to get a little perspective where next-generation sequencing has […]


NanoString’s Hyb & Seq Single Molecule Sequencer at #AGBT18

Background Back in 1989 in Belgrade Yugoslavia, Radoje Drmanac had an idea that would shape the next decade of genetic analysis, which was being able to sequence megabases of DNA information by a collection of 11-mers to 20-mers. Doing the mathematical calculations, this paper lays out what kind of DNA […]


NanoString’s Digital Spatial Profiling Microscope at #AGBT18

Now that another year has passed it is great to see the NanoString Digital Spatial profiling microscope near its commercial launch. The platform will be in early access to select customers in the fourth quarter of 2018, and full commercial launch in the first half of 2019. For those interested […]


Ion GeneStudio S5: The latest iteration of Thermo Fisher Scientific NGS 1

With the beginning of the influential JP Morgan Healthcare investor conference this week in San Francisco, you can expect an avalanche of news from companies large and small regarding all things therapuetic and diagnostic. With an official count of about 9,000 attendees, there are many more in San Francisco who […]


#AMP2017

Thoughts from the Association of Molecular Pathology conference #AMP2017

John Iafrede (Massachusetts General Hospital, MA) “There is a tidal wave of cell-free approaches; little performance testing; and the big question is who is going to pay for it.” This year’s Assocation for Molecular Pathology was held in Salt Lake City, Utah from November 15-18, 2017. (You can find the […]


Pillar Biosciences at Association for Molecular Pathology #AMP2017

While at the Association for Molecular Pathology in Salt Lake City Utah, I was able to interview Gang Song CEO of Pillar Biosciences to ask him about the challenges in the clinical laboratory that Pillar is tackling, about the basics of SLIMamp technology, and recent news. Check it out! #AMP2017


Association for Molecular Pathology annual meeting 2017 #AMP2017

Preview of Association for Molecular Pathology 2017 #AMP2017

With over 2000 clinical laboratory professionals in molecular diagnostics and pathology, plenty of technology and offerings on display. This year the Association for Molecular Pathology takes place in Salt Lake City Utah, and promises an abundance of new technology as well as the new accompanying science around diagnostic testing. Since […]