RT @00livier: RY: 20-40% of the regulatory machinery binds to ~200 super enhancers #AACR14
12:35pm April 6th 2014 via Hootsuite
Young: Cell ID controlled by master TF's, first-gen maps of transcriptional control circuitry have begun #AACR14
12:34pm April 6th 2014 via Hootsuite
Young: DNA methylation, nucleosome mods (Ac, Me, Ub, Su), nucleosome mobilization, then stereotypical patterns of histone marks #AACR14
12:33pm April 6th 2014 via Hootsuite
Young: Master TF's - occupy their own gene expression. A 'core auto-regulatory loop'. Figure from Cell 2013 paper #AACR14
12:32pm April 6th 2014 via Hootsuite
Plenary session: Richard Young, MIT / Whitehead "Transcriptional and epigenetic control of tumor cells{" #AACR14
12:23pm April 6th 2014 via Hootsuite
Cancer patient, to survivor, to cancer researcher Elana Simon's story as video. Dad is Rockefeller U cancer researcher #AACR14
12:00pm April 6th 2014 via Hootsuite
Dr. Hanahan's 2 seminal 'must-read' papers 'for anyone entering the field'. '11: http://t.co/szOmbRxZFH '00: http://t.co/4ed2qG2rCA #AACR14
11:52am April 6th 2014 via Hootsuite
Great job from the #AACR organizers with opening video. I've seen a lot of great Big Corporation ones, this one is right up there! #AACR14
11:24am April 6th 2014 via Hootsuite
Ken Burns will be doing 'Emporer of All Maladies' as an upcoming PBS special http://t.co/6tSU1FRiqZ #AACR14
11:19am April 6th 2014 via Hootsuite
Friend: A2:Inst. - felt that most institutions are afraid that others know what they are really doing. A trust in the lab -> Inst. #AACR1
10:59am April 6th 2014 via Hootsuite
Friend:Q:Wall of q's - why inst. instead of crowdsourced? A:Use Stack Overflow so people can look at Q, then data, then fund it #AACR14
10:57am April 6th 2014 via Hootsuite
Friend:Q:Elemental public health issues: how to begin to use extremes? A:Hope to find 1M people to send info. Had 20K goal, hit 500K #AACR14
10:55am April 6th 2014 via Hootsuite
Friend:Q:Can it expand wide, how long to take? A:DARPA's Arpanet was for data; took only 20y to evolve. Feedback loop: faster &wider #AA
10:53am April 6th 2014 via Hootsuite
Friend:Q:Framing as computation, become shallow, 'relax' after they are on top? A:Agreed, need for experts work together after #AACR14
10:51am April 6th 2014 via Hootsuite
Friend: A2: What works well is to integrate with 'new experts'. A need for editors - to coordinate efforts #AACR14
10:49am April 6th 2014 via Hootsuite
Friend: Q:Will there be tiers of researchers? (say genomics experts + housewives?) A: Absolutely not. Treat others as equals #AACR14
Friend: A shift in how we train - assume the rest of the world is ready and willing to work with the problems we have #AACR14
10:45am April 6th 2014 via Hootsuite
Friend: Lists a large set of new skills needed at the graduate level - data analytics, collaboration tools, generous with ideas... #AACR14
10:44am April 6th 2014 via Hootsuite
Friend: Data mined AACR13 abstracts and looked at relationships between topics and authors. Mon session: http://t.co/JBH7AGCWv8 #AACR14
10:43am April 6th 2014 via Hootsuite
Friend: At a meetings like #AACR - why can't we know who is doing what? Guinney / Dienstmann build a 'scientific interactome' in 2013
10:40am April 6th 2014 via Hootsuite
Friend: Existing companies just interact indiv's, research needs a much broader base for this kind of work #AACR14
10:39am April 6th 2014 via Hootsuite
Friend: Parkinson's Voice Initiative http://t.co/hEVK9mLel7 saying an 'ah' word, building voice data from the public #AACR14
10:38am April 6th 2014 via Hootsuite
Friend: Health data tracking - sometimes as a product (23andMe listed), but proposes a project called 'Bridge' #AACR14
10:36am April 6th 2014 via Hootsuite
Friend: Upcoming histopathology challenge needs to go farther - to get citizen involvement. Phenotypic data to match genotypic data #AACR14
10:35am April 6th 2014 via Hootsuite
Friend: For br cancer - DREAM has forums, leaderboards. 'If you want people to share, allow them to compete'. http://t.co/Euit2UQZu0 #AACR14
10:32am April 6th 2014 via Hootsuite
Friend: Pointed to this paper: http://t.co/AcUs53g2SQ and stated that it will in 10y become very prominent. 'Indiv systems medicine' #AACR14
10:28am April 6th 2014 via Hootsuite
Friend: Synapse enabled large-scale collaboration. 3 genome modifications x 3 systems x multiple analyses #AACR14
10:27am April 6th 2014 via Hootsuite
Friend: Project using #TCGA and Synapse (project) - publ. in a very short time. Onberg et al Nat Genet Pubmed http://t.co/vihWLkuUDd #AACR
10:25am April 6th 2014 via Hootsuite
Friend: 'Open social media allows citizens and experts to use gaming to solve problems'. SolveIt, Eterna - a housewife helping out #AACR
10:23am April 6th 2014 via Hootsuite
Friend: A generational, open approach for data-driven analysis. 'What if we could learn from everyone, everywhere?' #AACR
Meet Expert: S Friend, Sage Bionetworks "NextGen Cancer Res: Why the Existing Siloed, Guild-Like System Will Soon Be Less Relevant" #AACR14
10:21am April 6th 2014 via Hootsuite
3D printer price drops could lure home users - PC World http://t.co/qiVvektvNS
7:20am April 6th 2014 via Hootsuite
RT @PopSci: This is how you science: Geneticists create 3,500 fly strains to find one that moonwalks http://t.co/x5ctXhZCgy
6:20am April 6th 2014 via Hootsuite in reply to
Solid public-speaking advice RT @ValaAfshar: How to give a great speech | Forbes http://t.co/1XT7ib8a7M
5:20am April 6th 2014 via Hootsuite
Ivan Misner: Work-Life Balance Is a Sham| http://t.co/DuboEZ3NQY http://t.co/INlUne3ACp
4:20am April 6th 2014 via Hootsuite
RT @conradhackett: Who likes Americans? S Korea 80% Uganda 73 Japan 73 Canada 71 France 67 Russia 60 Mexico 59 China 39 Egypt 32 Trky 20
3:20am April 6th 2014 via Hootsuite
Using Hi-C NGS RT @thinkgenome: Scientists generate 3-D structure for the malaria parasite genome | MedXpress http://t.co/kwD5LKb2wB
2:20am April 6th 2014 via Hootsuite
RT @jordosh: Do you know an exceptional teacher? Nominate them for the $1 million Global #TeacherPrize http://t.co/WA2LXV3NAk
1:20am April 6th 2014 via Hootsuite
RT @AgilentGenomics: Our wildly popular NGS 101 series is now avail on-demand #RNA-Seq #Methyl-Seq, Data Analysis... http://t.co/WvmZB2pySJ
12:20am April 6th 2014 via Hootsuite
RT @MayoClinicCIM: Psychiatric #Genetics Hold Great Promise | Psychiatry Online http://t.co/qpvIhp8UxR
11:20pm April 5th 2014 via Hootsuite
RT @conradhackett: GOOD NEWS: US violent crime rate falling - the overall 2012 rate was the lowest in over 40 years. http://t.co/Wzk6a7EPIz
10:20pm April 5th 2014 via Hootsuite
Botstein: Conclude similarities - population evolution with a fitness advantage. The # of paths to increase fitness limited #AACR14
9:21pm April 5th 2014 via Hootsuite
Botstein: Metabolism - limit leucine, burn through glucose. Same with limited phosphate, uracil. Reminiscent of tumor cells #AACR14
9:19pm April 5th 2014 via Hootsuite
Botstein: Looked at a mating pathway with a reporter, 1K generations, Lang 2009 PubMed: http://t.co/fl4K90q0Qz #AACR14
9:10pm April 5th 2014 via Hootsuite
Botstein: 8 indep evolved strains have copy-number variation via aCGH; analysis showed similarities to BCR-ABL. #AACR14
8:56pm April 5th 2014 via Hootsuite
Botstein: References 1999 paper on up/down regulation of genes in yeast under glucose limitation PubMed http://t.co/Ari1cynWvH #AACR14
8:53pm April 5th 2014 via Hootsuite
Botstein: (Courtesy @deannachurch - 2012 talk at the NIH http://t.co/8IKXdsS8Ui ) #AACR14
8:51pm April 5th 2014 via Hootsuite
Botstein: Photo of Monod and Szilad; invented the Chemostat, enabling single-cell organism growth in a steady-state equilibrium #AACR14
8:48pm April 5th 2014 via Hootsuite
Botstein: A 'galaxy' of genes grouped by function; we understand about 2/3rds of the yeast genes #AACR14
8:46pm April 5th 2014 via Hootsuite
Botstein: Uses figure from this Constanzo 2010 Science article PubMed: http://t.co/etkPP1ACTb Functional relationships between yeast #AACR14
8:44pm April 5th 2014 via Hootsuite
