Kingsmore: Earnest Rady: started with $120M gift for a new institute. 'Children are an underserved community' #PMLS2016
12:14pm August 11th 2016 via Hootsuite
Stephen Kingsmore (CEO Radys Children's Hosp CA): Implementing universal pediatric precision medicine in SD #PMLS2016
12:13pm August 11th 2016 via Hootsuite
Dracopoli: With differing MOA, many other non-genetic profiles needed (protein and cell-based responses) #PMLS2016
12:10pm August 11th 2016 via Hootsuite
Dracopoli: For immuno-oncology - a diverse MOA (checkpoint inh, t-cell redir, cancer vaccines, Ab-dependent cellular cytotox) #PMLS2016
12:09pm August 11th 2016 via Hootsuite
Dracopoli: Discusses biomarker availability by trial phase; all single-analyte; for first-in-class drug, 'there isn't time' #PMLS2016
12:07pm August 11th 2016 via Hootsuite
Dracopoli: Why? Pt samples (training n>100, validation >500); markers; stable endpts (ORR changes to PFS, OS); algorithm dev #PMLS2016
12:05pm August 11th 2016 via Hootsuite
Dracopoli: Oncology CDx (companion Dx): 18 drugs against six targets. 15 years after HGP, 'this is not a success' #PMLS2016
12:04pm August 11th 2016 via Hootsuite
Dracopoli: Only 20/159 (13%) Oncology Rx approved (since '98) w/FDA-approved Companion Dx #PMLS2016
12:02pm August 11th 2016 via Hootsuite
Dracopoli: Probability of successful transition from Ph1 to approval - 8.4% w/o marker, 25.9% with. PDF: https://t.co/JIrPWwXrRX #PMLS2016
12:01pm August 11th 2016 via Hootsuite
Nicholas Dracopoli (Janssen R&D) 'Stakeholders Unite: Executive Overview of #PrecisionMedicine' #PMLS2016
11:58am August 11th 2016 via Hootsuite
Stephan: Describes the PMI as a 'token investment' ($200M). #PMLS2016
11:55am August 11th 2016 via Hootsuite
Stephan: Without a strategy, no one will buy into PM. We are operating at a tactical level, 'bumping around w/o a strategy' #PMLS2016
11:52am August 11th 2016 via Hootsuite
Stephan: Why is there no budget line for cures and therapies for personalized medicine/therapy? #PMLS2016
11:47am August 11th 2016 via Hootsuite
Stephan: US spends $65B on soft drinks. March of Dimes crowdsourced the cure for polio. $1.6B spent on the Secret Service. #PMLS2016
11:46am August 11th 2016 via Hootsuite
Stephan: Have we done a poor job of describing the problem? The investment needed and potential payoff in the future? #PMLS2016
11:45am August 11th 2016 via Hootsuite
Stephan: CMS has a $900B budget; what about 0.5% for clinical WGS? And collection, phenotyping, data mgmt, IT support? #PMLS2016
Stephan: What is the leveraging and monetization strategy to flywheel everything up? Wouldn't companies want to warehouse? #PMLS2016
11:44am August 11th 2016 via Hootsuite
Stephan: Is the PMI having discussion with the stakeholders for how it will flow down? 1M sequences 'is not nearly enough' #PMLS2016
11:43am August 11th 2016 via Hootsuite
Stephan: The points of friction need to be articulated, addressed. "I've heard no serious discussion about how to leverage PMI" #PMLS2016
11:42am August 11th 2016 via Hootsuite
Stephan: 'We have not done a good job of informing other stakeholders of the efficacy of precision medicine' #PMLS2016
11:35am August 11th 2016 via Hootsuite
Stephan: Decided to get test anyway, and look at downstream pathways (PIK3CA / mTOR, and RAS / MAPK) looked at alternative inh Rx #PMLS2016
11:30am August 11th 2016 via Hootsuite
Stephan: Rec'd germline only, rather than both germline and somatic. What economic calculators are being used? #PMLS2016
11:28am August 11th 2016 via Hootsuite
Stephan: (Denied via Blue Cross/Shield website). Upon re-submission: 'a nameless, faceless person rejected request' #PMLS2016
11:27am August 11th 2016 via Hootsuite
Stephan: After review, determined Parkes Weber syndrome, due to suspected RASA1 mutation. Denied for test (!) #PMLS2016
11:26am August 11th 2016 via Hootsuite
Stephan: Turns out to be a driver oncology gene (mKT/mTor mutation), Rx ineffective. Assembled multi-disc team. #PMLS2016
11:25am August 11th 2016 via Hootsuite
Stephan: Artery problems; bleeding; wears diapers; affected hip and leg. 10y of top-tier examinations. Dx: Klippel-Trenaunay Syn #PMLS2016
11:23am August 11th 2016 via Hootsuite
Stephan: Starts with a story of an adolescent boy in constant pain. Bullied, sad, only remedy is hot baths #PMLS2016
11:20am August 11th 2016 via Hootsuite
Dietech Stephan (U Pitt): "Truth, Friction and the Dream" #PMLS2016
11:18am August 11th 2016 via Hootsuite
Hakan Sakul (Pfizer) "We are here to discuss the issues facing Precision Medicine"; roundtable format setup for active discussion #PMLS2016
11:14am August 11th 2016 via Hootsuite
Tweets from the Precision Medicine Leaders Summit. Agenda: https://t.co/6AogpTBLLM #PMLS2016 Spkrs include Dietrich Stephan, many panels
11:09am August 11th 2016 via Hootsuite
How a small Florida town is standing in the way of stopping Zika in the US | Fusion https://t.co/IBVzyBibHi
11:20pm August 10th 2016 via Hootsuite
RT @MTraziWilliams: A graphical guide to the impact of the Olympics on science https://t.co/pVbrfFYnGB via @NatureNews https://t.co/TcNcxhc…
2:34pm August 9th 2016 via Hootsuite
Summer Reading Suggestions from Scientists: Harold Varmus | NIH Director's Blog https://t.co/NKAkVQqzcF
12:22pm August 9th 2016 via Hootsuite
ArcherDx NGS Assays Receive Conditional Approval From NY State Department of Health | GenomeWeb https://t.co/Iw8bQG2ABm
11:13am August 9th 2016 via Hootsuite
Unpacking the innards of Theranos’s new Zika-detection box | TechCrunch https://t.co/c5bJ0vQNSx
7:46pm August 8th 2016 via Hootsuite
Bristol-Myers Squibb's Defeat Is A Victory For Personalized Medicine - Forbes https://t.co/A5XVr3Iiqe
10:58am August 8th 2016 via Hootsuite
FDA-AACR Liquid Biopsies in Oncology Drug and Device Workshop https://t.co/eLaDKk9tVm #FDA
9:33am August 8th 2016 via Twitter Web Client
Frequent-flier programs could face tighter regulation — if customers speak up - The Washington Post https://t.co/lq3F9hdbtF
3:03pm August 7th 2016 via Hootsuite
Yes, Serious Academics Should Absolutely Use Social Media - Forbes https://t.co/S9uE2gqJjH
1:46pm August 7th 2016 via Hootsuite
The Apple Watch does the exact opposite of what it is supposed to do — Quartz https://t.co/zhrI0dkpzY
2:00pm August 6th 2016 via Hootsuite
Startups may be losing their value faster than anytime in last five years — Quartz https://t.co/XfvPXyelhI
2:16pm August 5th 2016 via Hootsuite
NanoString Q2 Revenues Up 73 Percent | GenomeWeb https://t.co/4qRda1ZmS3
11:41am August 5th 2016 via Hootsuite
Crashing, Burning Planes Don’t Stop Passengers From Grabbing Their Luggage - Bloomberg https://t.co/TfpaKOT6gj
4:15pm August 4th 2016 via Hootsuite
Nice TMO Oncomine data using @SeraCare fusion RNA FFPE reference at #AACC2016 https://t.co/pLqdZ5Whcs
10:28am August 3rd 2016 via Hootsuite
Interesting @SeraCare NGS data cross-platform, inter-lab study data (Theater 2) https://t.co/PpqbXh79lZ
10:23am August 3rd 2016 via Hootsuite
In theater 2, @SeraCare presents their technology approach toward multiplexed reference standards https://t.co/uIbAwnkYW8
10:21am August 3rd 2016 via Hootsuite
In Theater 2 (row 3700) a big challenge is the scarcity of patient samples. https://t.co/uvVgCKbWjF
10:18am August 3rd 2016 via Hootsuite
Russell Garlick at #AACC2016 in Theater 2 (row 3700) on NGS Challenges in the clinical lab
10:17am August 3rd 2016 via Hootsuite
#aacc2016 Now in Theater 2 (row 3700) in exhibit hall via @seracare Overcoming pain points of clinical NGS testing https://t.co/VVO0Wc9HZN
10:10am August 3rd 2016 via Hootsuite
MDACC Research Demonstrates Clinical Applicability of ANGLE ‘Blood Biopsy’ Technology | Business Wire https://t.co/L0MioG016Q
9:15pm August 2nd 2016 via Hootsuite
