Mattick: Shows papers from FANTOM and RIKEN consortiums - 30K with unknown function; 44% of transcripts w/o polyA+ #AGBT18
6:10pm February 12th 2018 via Hootsuite
Mattick: Shows drawings of vertebrae: precise. The level of control in 4 dimensions; fig from '07 review https://t.co/40bHzw5Rbs #AGBT18
6:08pm February 12th 2018 via Hootsuite
Mattick: But where is the informatoin that programs human developmental and cognitive complexity? "It's the architecture." #AGBT18
6:07pm February 12th 2018 via Hootsuite
Mattick: Starts with comparing humans to c elegans: both have approx 20k protein-coding genes. Most orthologous, similar fn. #AGBT18
6:06pm February 12th 2018 via Hootsuite
John Mattick (Garvan Inst Sydney AUS) Modular structure and plasticity of regulatory RNA #AGBT18
6:04pm February 12th 2018 via Hootsuite
Q: How to get high MW DNA, but also beating up the sample? Bhatt: We use lots of methods; electrical voltage. A real challenge.#AGBT18
6:02pm February 12th 2018 via Hootsuite
Bhatt: 'Microbial evolution on a clinical timescale' - shape-shifting genomes, perhaps contributing to antibiotic resistance. #AGBT18
5:59pm February 12th 2018 via Hootsuite
Bhatt: Shows transposon w/an antibiotic resistance gene (norM), an efflux pump. Only difference was insertion seq #AGBT18
5:56pm February 12th 2018 via Hootsuite
Bhatt: Shows a 60kb horizontally transferred gene segment from a patient in real-time. #AGBT18
5:54pm February 12th 2018 via Hootsuite
Bhatt: #AGBT18 Her most recent work: BioarXiv: https://t.co/INhzAR8eQ6 (posted 2/11/18)
Bhatt: Called read cloud sequencing, combined with assembly using Athena. BioarXiv: https://t.co/A5Y4kfehT4 #AGBT18
5:52pm February 12th 2018 via Hootsuite
Bhatt: 'I can trace a path through this if I had a long enough read' to measure gene transfer. Applied 10X Genomics to this #AGBT18
5:47pm February 12th 2018 via Hootsuite
Bhatt: Illustrates collapse of complexity with compiling lots of 16S reads. Horizontal gene transfer: increasing fitness, growth #AGBT18
5:45pm February 12th 2018 via Hootsuite
Bhatt: Oligodomination and seafloor sediment: most organisms are unknown. Repeated seq 'confound seq & assembly approaches' #AGBT18
5:42pm February 12th 2018 via Hootsuite
Bhatt: "Maddenly complex." Metagenomics cannot "link taxonomy to function". "Who is there? 16S. What do they do? Shotgun." #AGBT18
5:40pm February 12th 2018 via Hootsuite
Bhatt: In these sediments; 'with all our seq tech, we can't figure out WHO is doing WHAT?' #AGBT18
5:39pm February 12th 2018 via Hootsuite
Bhatt: Is it a superbug? Acquired genes? All 'no'. Another mystery case: a research ship in Pacific make ocean floor sediment cores #AGBT18
Bhatt: Q:how does oligodomination happen? After HCT (transplantation), one bacteriodes spp dominates. 30-50% of pts #AGBT18
5:37pm February 12th 2018 via Hootsuite
Bhatt: Pts get diseases - GVD, infections. Individual got neutropenia, and GVD. Often observe post-transplant loss of diversity #AGBT18
5:36pm February 12th 2018 via Hootsuite
Bhatt: Irradiation or anticancer drug kills bone marrow, stem cells donated and injected. "And then we sit around and wait" #AGBT18
Bhatt: 46yo male w/myelodysplastic disease, underwent allogeneic hematopoietic cell transplant. Shares background on process #AGBT18
5:35pm February 12th 2018 via Hootsuite
Ami Bhatt (Stanford Univ) Shape-shifting microbial genomes in the human microbiome #AGBT18
5:34pm February 12th 2018 via Hootsuite
Marques: Multi-exonic elincRNAs are assoc'd with more frequent DNA/DNA contact; and local chromosomal architecture. #AGBT18
5:25pm February 12th 2018 via Hootsuite
Marques: 50% of elincRNAs are multiexonic; is the mature transcript impt? The question - how does elincRNA splicing affect cis-exp? #AGBT18
5:20pm February 12th 2018 via Hootsuite
Marques: shRNA knockdown experiments - Mani could be a pleuripotent factor. #AGBT18
5:18pm February 12th 2018 via Hootsuite
Marques: Shows interactoin within mESC; linc-MoP interacts w/promoter sitting 1MB downstream. #AGBT18
5:15pm February 12th 2018 via Hootsuite
Marques: What is the physiological impact, and features/motifs? Starts w/example of pluripotency modulation. #AGBT18
5:13pm February 12th 2018 via Hootsuite
Marques:50% of lincRNAs arise from enh's. '13 ref https://t.co/9GzBAWYI0d elincRNAs assoc' w/50% inc expression of adjacent genes #AGBT18
5:12pm February 12th 2018 via Hootsuite
Marques: Shows diagram - active enhancers are xcribed; a few are unidirectional, stable in one direction. Bidir are unstable. #AGBT18
5:10pm February 12th 2018 via Hootsuite
Marques: Consensus "lincRNAs can contribute to impt aspect of eukaryotic biology, and not simply the product of xcriptional noise" #AGBT18
5:08pm February 12th 2018 via Hootsuite
Marques: Their focus - >200bp lincRNA completely intergenic of protein-coding regions. #AGBT18
5:07pm February 12th 2018 via Hootsuite
Ana Claudia Marques (Univ Lausanne CH) An unexpected contribution of lincRNA splicing to enhancer function #AGBT18
Elaine Mardis giving a short intro at #AGBT18 https://t.co/WVK3dKmSTS
5:06pm February 12th 2018 via Hootsuite
George Weinstock opening #AGBT18 - explaining why we’re not back at Marco Is. https://t.co/XQe1ZIW2tq
5:02pm February 12th 2018 via Hootsuite
What Clinicians Need to Know About Vitamins and Mineral Supplements | JAMA (Free) https://t.co/4rodN0ciQR
7:00am February 10th 2018 via Hootsuite
82nd National Advisory Council webcast Monday Feb 12 10am EST GenomeTV Live - NHGRI https://t.co/5zpriAtvMf
6:10pm February 9th 2018 via Hootsuite
Qiagen, Sentieon Extend Data-Analysis Partnership to Clinical Genomics | GenomeWeb ($) https://t.co/RDDmFMjpw2
2:10pm February 9th 2018 via Hootsuite
Xconomy: Andreessen-Horowitz A16Z Bio Fund’s Pande Sees A.I. as Way to Ride Bio Innovation https://t.co/WbrepQHBx6
1:56pm February 9th 2018 via Hootsuite
Genalyte Start-Up Develops POC Device for Fast Blood Tests | Dark Daily https://t.co/5vTQDomefE
10:48am February 9th 2018 via Hootsuite
Labyrinth Chip Design Captures Circulating Tumor Cells | Dark Daily https://t.co/ZEqM0hXsaB
5:15pm February 2nd 2018 via Hootsuite
MT @sema4: Data and medicine: A revolution is coming https://t.co/7i1o8REm4o via @TheEconomist #genomics #AI https://t.co/xUgZluq7YQ
4:55pm February 2nd 2018 via Hootsuite
Clinical WGS from routine FFPE specimens: pilot study for the 100K Genomes Project | Genetics in Medicine (OA) https://t.co/ZA94WXmg2f
3:41pm February 2nd 2018 via Hootsuite
