RT @pavitrarc: .@torstenseemann describes a bioinformatician's average Tuesday #ASMNGS18 https://t.co/LidFIAYXFl
11:35am September 26th 2018 via Hootsuite Inc.
The end of HIV transmission in the U.S.: A once-thinkable dream becomes an openly discussed goal | Stat News https://t.co/021p7U2INW
10:30am September 26th 2018 via Hootsuite Inc.
A Deeper Dive into the BioHealth Capital Region’s #4 Spot on GEN’s Top 10 U.S. Biopharma Clusters List | BioBuzz https://t.co/P0yAEGXJhw
9:19am September 26th 2018 via Hootsuite Inc.
I donated to @mozilla today because I #lovetheweb. Join me and help build + protect the Web forever https://t.co/TKnSfxKhBk
8:42am September 26th 2018 via Twitter for iPhone
RT @gottfriedjeff: NEW: Just 4% of Americans have a lot of trust in the information they get from social media.… https://t.co/BHTtW78OwC
2:30pm September 25th 2018 via Hootsuite Inc.
Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA |… https://t.co/bFTFlkuaB3
1:30pm September 25th 2018 via Hootsuite Inc.
ICYMI New Post: The value proposition of precision oncology requires careful education - Pillar Biosciences Blog https://t.co/hlSfkzabDT
12:16pm September 25th 2018 via Hootsuite Inc.
New Post: The value proposition of precision oncology requires careful education - Pillar Biosciences Blog https://t.co/hlSfkzabDT
4:45pm September 24th 2018 via Hootsuite Inc.
"Every time I diagnose colorectal cancer, I feel like the system has failed." | Stat News https://t.co/7dT7wvofyx
Have you heard of the Brave Browser? The Crypto Project that is Disrupting a $300 Billion Industry | Medium https://t.co/0e6M4W8vMT
3:30pm September 24th 2018 via Hootsuite Inc.
Xconomy: With OneOncology, Flatiron and Cancer Docs Aim to Boost Community Care https://t.co/G2HfNsoBtT
10:15am September 20th 2018 via Buffer
The Brave browser has a new 'Basic Attention Token' model to replace advertising on the Web - worth a look. Vimeo… https://t.co/b2EfUaZfeZ
9:14am September 20th 2018 via Buffer
Speeches by FDA Officials > Blueprint for Breakthroughs - Charting the Course for Precision Medicine | FDA Gottlieb… https://t.co/9lgQ9gq
11:05am September 17th 2018 via Hootsuite Inc.
Cancer Spreads from Organ Donor to Four People in ‘Extraordinary’ Case | Live Science https://t.co/jPOQRWNyfo
10:30am September 17th 2018 via Hootsuite Inc.
How nucleic acid memory could be used to store data in DNA | VentureBeat #longread https://t.co/B4yUzhm8R0
9:25am September 17th 2018 via Hootsuite Inc.
ICYMI: David Altshuler at #AGBTph18: Diverse Perspectives on Genomic Medicine - Pillar Biosciences https://t.co/Un1a1KmeIH
8:05am September 17th 2018 via Hootsuite Inc.
What really defines wisdom in the workplace - an example from AirBnB | Fast Company https://t.co/SQIgx8bB7i
7:05am September 17th 2018 via Hootsuite Inc.
@ctitusbrown @FastMail When I decided to get out of the 'Goolag' I have been a happy @fastmail customer now for over a year. Well worth it.
4:03pm September 16th 2018 via Hootsuite Inc. in reply to ctitusbrown
New Post: David Altshuler at #AGBTph18: Diverse Perspectives on Genomic Medicine - Pillar Biosciences https://t.co/Un1a1KmeIH
10:41am September 14th 2018 via Hootsuite Inc.
UCLA scientist shares 2018 Lasker Prize for figuring out how genes turn on and off | LA Times https://t.co/A2Qb6HcShf
10:35pm September 11th 2018 via Hootsuite Inc.
Great Pacific Garbage Patch Plastic Collector Set to Launch | Nat'l Geographic https://t.co/8A6pr3h5Y2
3:15pm September 11th 2018 via Hootsuite Inc.
Pivotal CRISPR patent battle won by Broad Institute | Nature News https://t.co/iNhxX0biU4
2:02pm September 11th 2018 via Hootsuite Inc.
Plon #AGBTph18 As expected the majority have negative germline reports. Unexpected results include one case where g… https://t.co/hfBAvy3n4I
8:29pm September 8th 2018 via Twitter Web Client
Plon #AGBTph18 Seen a large variety of germline findings, including TP53, NF1, BRCA1/2, CHEK2, RB1, SMARCA4 in neuroblastoma.
8:25pm September 8th 2018 via Twitter Web Client
Plon #AGBTph18 Blood samples, 2w TAT, shows MATCHBOX plus germline modification. Goal 1500; study started Aug '17; n=296 as of today.
8:24pm September 8th 2018 via Twitter Web Client
Plon #AGBTph18 Not all cancer suscept genes are included (e.g. DICER1). Genetic counselling available, educational resources.
8:22pm September 8th 2018 via Twitter Web Client
Plon #AGBTph18 What is missing: not systematic sequencing of genes (as if for germline). Adult MATCH: did not inter… https://t.co/IXvSzppByP
8:21pm September 8th 2018 via Twitter Web Client
Plon #AGBTph18 Two dedicated labs (CHLA, Baylor) reoutinely report herid cancer results; pathogenic, likely path, VUS if included on report.
8:20pm September 8th 2018 via Twitter Web Client
Plon #AGBTph18 Two-hit hypothesis: RB1, WT1, TP53, NF1: same gene may undergo somatic or germline mutations.
8:17pm September 8th 2018 via Twitter Web Client
Plon #AGBTph18 Combined RNA and DNA, 140 genes. About 10% of unselected ped cancer pts have underlying germline mutations
8:16pm September 8th 2018 via Twitter Web Client
Plon #AGBTph18 COG - Children's Oncology Group. Nothing about germline analysis is a primary obj. Relapse, and refr… https://t.co/UIIp72Mzy3
8:13pm September 8th 2018 via Twitter Web Client
Plon #AGBTph18 PEC-MATCH: Project Every Child; a COG-wide single-stage PhII trial of genomically-directed Rx for ch… https://t.co/nKBxPY7oNe
8:11pm September 8th 2018 via Twitter Web Client
Sharon Plon (Baylor) #AGBTph18 Germline reporting in the National Cancer Institute – Children’s Oncology Group (NCI… https://t.co/vvUc33g0Ta
8:10pm September 8th 2018 via Twitter Web Client
Berger #AGBTph18 '17 ref https://t.co/zfjJcYEjFT Treating pts based on novel hotspot muts, basket trial efficacy.
7:44pm September 8th 2018 via Twitter Web Client
Berger #AGBTph18 IMPACT: 468 genes to guide treatment. 1.52Mb, ave 720x coverage. Exons from 468 genes, 20 gene int… https://t.co/gS3Id1wiHI
7:40pm September 8th 2018 via Twitter Web Client
Berger #AGBTph18 Precision oncology req's large-scale molecular profiling; scalable, fast, affordable, low freq sens, flexible.
7:39pm September 8th 2018 via Twitter Web Client
Berger #AGBTph18 BRAF occurs also in lung adenocarcinoma. Observations on dabrafenib and trametinib lead to FDA app… https://t.co/7T1A2m5UwJ
7:38pm September 8th 2018 via Twitter Web Client
Michael Berger (MSKCC) #AGBTph18 Tumor and normal clinical sequencing to guide diagnosis and treatment selection
7:36pm September 8th 2018 via Twitter Web Client
Q: Is lower coverage possible? Nik-Zainal #AGBTph18 10X coverage did drop sens, as well as WES 60-70% sens. Cost: W… https://t.co/f04nl6IWc2
7:34pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 Only 30yo, studying for a PhD, and needs add'l funds to continue treatment (trying to raise 100K)
7:31pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 Oncologists - thinking it was only sarcoma, 3rd-line Rx. Trying to raise funds for Joshua Barn… https://t.co/m79RfhMl4Q
7:30pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 Sig similar to POLE mut, showed phylogenetic tree, POLE sens to checkpt inh; looked at PD-1 ne… https://t.co/l106Eeknv3
7:29pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 Finishes with 'individualized whole cancer genomics' story. Angiosarcoma, 800K mutations in ci… https://t.co/WMPFMEU8Hb
7:28pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 Expect that will go to 'scanning WGS'. HRDetect discriminates pts w/good clin outcome on ACT.
7:25pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 70% explained by BRCA status, HRDetect predicts outcome. MMRd in br ca: an undetected and untreated class of tumors
7:24pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 A collection of signatures - more likely to detect it. '10-'15, 4,077 samples w/treatment, n=2… https://t.co/t7nIqy1cBs
7:20pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 BRCA1 with loss of allele, shows circos plots, and HRDetect ID's add'l BRCA1/2 defective tumors https://t.co/C3It8cQH6I
7:17pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 Validating this: has erythroblast-derived iPSCs, isogenic CRISPR-Cas9 K-O's, and recapitulate… https://t.co/AraVYpApIk
7:14pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 PMS2-null, has thousands of inserts, where MSI may not find. 'WGS can reveal abnormal biology… https://t.co/LXVkDVKYpv
7:12pm September 8th 2018 via Twitter Web Client
Nik-Zainal #AGBTph18 Overlaying MMR, mutational load, and ER status, and some with APOBEC sig '17 ref https://t.co/Y1812PkMk9
7:11pm September 8th 2018 via Twitter Web Client
