Bernal: #MDxEU17 Some metabolic work in '10 https://t.co/SAuC8QnQu2 Shows summary predictive value of 'normal' preg https://t.co/NsLsS1Tn1D
10:57am April 10th 2017 via Hootsuite
Bernal: In human labor, no drop in progesterone. Not yet discovered yet in humans. Known a fetal zone w/fetal adrenal gland #MDxEU17
10:54am April 10th 2017 via Hootsuite
Bernal: Fetus and mother 'work together' as a maternal-fetal-placental unit. Conjugated androgens prod by placenta - DHA-S #MDxEU17
10:53am April 10th 2017 via Hootsuite
Bernal: Another risk factor - prev pre-term birth. Summarizes this section w/heterogeneous causes of preterm birth #MDxEU17
10:51am April 10th 2017 via Hootsuite
Bernal: And even passive (second-hand) smoke. Mechanisms: could be hypoxia of fetus, risk of membrane rupture. #MDxEU17
10:47am April 10th 2017 via Hootsuite
Bernal: #MDxEU17 15K women - showed active smoking and pre-term birth, one of few preventable causes '15 ref https://t.co/y4cFwjl93b
10:45am April 10th 2017 via Hootsuite
Bernal: Etiology - 45% is spontaneous. '10 ref https://t.co/QnLJlQ1bYe shows socioeconomic factors - tobacco, 'social problems' #MDxEU17
10:44am April 10th 2017 via Hootsuite
Bernal: #MDxEU17 Uses definitions from this '08 ref https://t.co/k1TKPSJs8d Very pre-term ~32w. Shows survival limit at 24w
10:42am April 10th 2017 via Hootsuite
Bernal: Cervix changes as well - a hard organ softening driven by matrix metallopoteinases (MMP-9) #MDxEU17
10:39am April 10th 2017 via Hootsuite
Bernal: Myometrial contractility via biochemistry, and ion channels regulating action potential w/calcium build-up. #MDxEU17
10:38am April 10th 2017 via Hootsuite
Bernal: 7M children <12yo are affected by preterm birth. Shows a painting from 1300's of Eve being extracted from Adam for context #MDxEU
10:37am April 10th 2017 via Hootsuite
Bernal: Uterus is a remarkable organ, also hard to study - due to changes in the smooth muscle in pregnancy. Yet contracts in labor #MDxEU17
10:36am April 10th 2017 via Hootsuite
A Lopez Bernal (Univ Bristol UK) Risk factors and proteomic biomarkers for pre-term labour #MDxEU17
10:34am April 10th 2017 via Hootsuite
Q: Number of women to treat via aspirin to prevent 1 case? Meiri: For high-risk, it is 1:10 (1 response for 10 treated) #MDxEU17
10:33am April 10th 2017 via Hootsuite
Q: Prevalence of mutation freq w/in ethnicities? Meiri: Black females in SA vs UK - different tribal assoc'ns #MDxEU17
10:32am April 10th 2017 via Hootsuite
Meiri: Shows in-vivo affect of WT PP13 protein admin in a rat model, cp to truncated PP13 '16 ref https://t.co/fTAf5FtQ5O #MDxEU17
10:27am April 10th 2017 via Hootsuite
Meiri: Normally, trophoblast invasion; pre-ecl fails. PP13 diverted in immune tolerance in preg mother; PP13 induces WBC apoptosis #MDxEU17
10:25am April 10th 2017 via Hootsuite
Meiri: DelT221 in PP13 among South Africans, enrichment for pre-eclampsia (7.2% vs. 2.4%) #MDxEU17
10:23am April 10th 2017 via Hootsuite
Meiri: Promoter polymorphism lowers expression; also stop codon for exon 2 (out of four total) of premature stop, truncating PP13 #MDxEU17
10:21am April 10th 2017 via Hootsuite
Meiri: (Background of ASPRE from EU funding organization https://t.co/OsM4a69ZSH ) #MDxEU17
10:20am April 10th 2017 via Hootsuite
Meiri: First trimester pts, Sanger seq of promoter region "-98 A/C" C base is protective allele. #MDxEU17
10:17am April 10th 2017 via Hootsuite
Meiri: Maternal blood PP13 - shows data from '08 ref on PP13 https://t.co/Q7G0d6lYlj in cases of pre-eclampsia during pregnancy #MDxEU17
10:16am April 10th 2017 via Hootsuite
Nice to meet @KaitlinSearfoss in-person here at #MDxEU17 to talk about live-tweeting conferences. Much harder than it appears...
10:14am April 10th 2017 via Hootsuite
Meiri: 150mg/d from 12-36wks. 10% of top 1:100 risk; went after one of several risk factors ID'd #MDxEU17
10:12am April 10th 2017 via Hootsuite
Meiri: 80% drop in pre-eclampsia at <34 weeks, manuscript submitted to NEJM. Aspirin enlarges spiral arteries - but why early? #MDxEU17
Meiri: Risk factors are age, weight, height, ethnicity, obstetric history. 14 centers thru-out EU. 100% prediction <32y, 44% >37y. #MD
10:09am April 10th 2017 via Hootsuite
Meiri: Signals sent to maternal blood. ASPRE project - first trimester prediction and preventioin via aspirin. #MDxEU17
10:08am April 10th 2017 via Hootsuite
Meiri: 2-5% of circul in normal life; blood volume inc 50X during development. Placental remodeling of spiral. Preecl. - no remodel #MDxEU17
10:07am April 10th 2017 via Hootsuite
Meiri: Fetus has many affects - obesity, diabetes in adolescence, physiol injury. Pts born under pre-eclampsia likely to be affected#MDxEU17
10:06am April 10th 2017 via Hootsuite
Meiri: Pre-eclampsia many underlying causes. 59K mothers die of this every year; CNS seizures, hepatic failure, platelet disorder #MDxEU17
10:05am April 10th 2017 via Hootsuite
Hamutal Meiri (ASPRE Is) Polymorphism in the promoter region of the placenta protein 13/LGALS13 gene as biomarker for pre-eclampsia #MDxEu17
10:03am April 10th 2017 via Hootsuite
RT @kaitlinsearfoss: Hear from Ida Vogel on Chromosomal Microarray in #Prenatal #Diagnostics– Lessons from More Than 1500 Analyses. #MDxEU17
9:49am April 10th 2017 via Hootsuite
Q: What limitations of NGS need to be overcome? Nevado: Prenatal NGS may not be a crazy idea, aCGH for prenatal impt #MDxE17
9:12am April 10th 2017 via Hootsuite
Nevado: Mentions in conclusion - is sequencing from the start (birth) crazy (referring to '13 Nature news piece)? No it isn't. #MDxE17
9:11am April 10th 2017 via Hootsuite
Nevado: Future - want to replace conven. karyotyping with invasive prenatal samples w/aCGH. NIPT is not a Dx test; it is screning #MDxE17
9:09am April 10th 2017 via Hootsuite
Nevado: until NIPT technology offers CNV detection across the genome, and less expensive, CMA as invasive tool is impt. #MDxE17
9:07am April 10th 2017 via Hootsuite
Julian Nevado (INGEMM, Spain) aCGH as a first-tier test in all invasive prenatal samples #MDxE17
9:06am April 10th 2017 via Hootsuite
In beautiful Lisbon this week for CHI Molecular Diagnostics Europe https://t.co/psvbb2vaUS #MDxE17 A few notes ff on Prenatal MDx
9:05am April 10th 2017 via Hootsuite
23andMe Rides Again: FDA Clears Genetic Tests To Predict Disease Risk | Forbes https://t.co/uvLZ0DqEbQ
8:56am April 10th 2017 via Hootsuite
"The Breakdown of Biomedical Research" - agree with Herper RT @matthewherper: This seems way overdone. https://t.co/0XCtBuaTVr via @WSJ
2:05pm April 8th 2017 via Hootsuite
Walt Mossberg is retiring in June - The Verge https://t.co/zoautudbO6
12:49pm April 8th 2017 via Hootsuite
Wrongful Death Suit Awaits Input From South Carolina Supreme Court | GenomeWeb ($) https://t.co/FCNkT9fyiH
2:51pm April 7th 2017 via Hootsuite
RT @SeraCare: What has been the biggest advance in #genomics in the last 5 years? https://t.co/cxYU7nCg35 https://t.co/sSnMgq1gJq
9:39am April 7th 2017 via Hootsuite
@niazafghan Of course! If you'd like to correspond via email my personal address is dale (at) https://t.co/yXJMjujFNx
9:38am April 7th 2017 via Hootsuite in reply to niazafghan
Michael Caligiuri (The Ohio State Univ OH): Vision for the Future #AACR17 Spotlight cancer health disparities research; preserve workforce
1:19pm April 5th 2017 via Hootsuite
Davidson: Carpten points out that of 333 prostate cancer samples in TCGA, only 25 are from Af Americans #AACR17
1:17pm April 5th 2017 via Hootsuite
Davidson: John Carpten's diagram - precision prevention, precision prognostics, precision therapy. #AACR17
1:16pm April 5th 2017 via Hootsuite
Davidson: Racial and ethnic minorities are still underrepresented in genomic ressearch; 1/3 of Af Americans would participate in PMI #AACR17
Davidson: Prec med a double-edged sword - could hurt by further exacerbating access due to existing healthcare disparaties #AACR17
1:15pm April 5th 2017 via Hootsuite
Davidson: The promise of immunoprevention - already here with HPV, HBV vaccines. Two ex, a-MUC1 vaccine, low-grade glioma vaccine #AACR17
1:11pm April 5th 2017 via Hootsuite
