Tweets from Hootsuite

Cheng #ASHG18 Shows PCA overlaid with tissue clusters. Kidney contribution correlate w/donor fraction. '17 ref https://t.co/b6bKUh7E43

12:24pm October 18th 2018 via Hootsuite Inc.

Cheng #ASHG18 did ss WGBS (2-5x coverage) from kidney transplant pts. n= ~50. ssDNA: urinary cfDNA is short, degraded, damaged.

12:21pm October 18th 2018 via Hootsuite Inc.

Cheng #ASHG18 Now WGBS on urinary cfDNA; 19K kidney transplants/y; 30% dev BK polyomavirus reactivation; 75% dev UTIs.

12:21pm October 18th 2018 via Hootsuite Inc.

Cheng #ASHG18 Shows results from 110 ref materials, and PCA plots showing grouping at organ and cell-type levels.

12:20pm October 18th 2018 via Hootsuite Inc.

Cheng #ASHG18 Metagenomic assay informing host response - tissue-spec methylation markers, to help det where infectious site occurs

12:19pm October 18th 2018 via Hootsuite Inc.

Cheng #ASHG18 Half-life of cfDNA is ~30min. Using urinary cfDNA to look for UTI. '18 ref https://t.co/8fi9bekhqZ 'A versatile analyte'

12:18pm October 18th 2018 via Hootsuite Inc.

Alex Cheng (Cornell) #ASHG18 Distinguishing inf from inf disease using methylation marks comprised within cell-free DNA

12:17pm October 18th 2018 via Hootsuite Inc.

van den Oord #ASHG18 Different mech - current vs cumulative; substantial overlap with WAS, other MWAS of health outcomes

12:15pm October 18th 2018 via Hootsuite Inc.

van den Oord #ASHG18 Method used when many more predictors than effects. Concl: T-cells, granulocytes methylome 'substantial impact'.

12:15pm October 18th 2018 via Hootsuite Inc.

van den Oord #ASHG18 Have to look at spec celltypes in blood; Tool RaMWAS '18 ref https://t.co/KMy6BULHoE

12:07pm October 18th 2018 via Hootsuite Inc.

van den Oord #ASHG18 Covers ~94% of WGS. Only 5-10% of reagent cost, 15x faster, methylome-wide at cost of arrays.

12:06pm October 18th 2018 via Hootsuite Inc.

van den Oord #ASHG18 Method - optimized MBD-seq (methyl-binding protein). Shows chart w/comparison with WG-Bisulfite seq.

12:05pm October 18th 2018 via Hootsuite Inc.

#ASHG18 Edwin van den Oord (VCU) Dev methylomics of childhood trauma and its health consequences

12:02pm October 18th 2018 via Hootsuite Inc.

For those at #ASHG18, this will be presented at 945am today in Room 6C https://t.co/xdNb3Rg4RW

11:57am October 18th 2018 via Hootsuite Inc.

RT @ceccerslike: "Detecting cancer four years before conventional diagnosis" https://t.co/KisKfFL5Ye by @DaleYuzuki on @LinkedIn

11:56am October 18th 2018 via Hootsuite Inc.

Konigshofer #ASHG18 About 1/2 are around 5%; about another half in the 3% range.

4:39pm October 17th 2018 via Hootsuite Inc.

Hi #ASHG18 take a look at an interesting methylation haplotyping poster from cell-free DNA #2793 - early detection of CRC

4:36pm October 17th 2018 via Hootsuite Inc.

Konigshofer #ASHG18 Shows interesting representation of interlab study results - for their AF10 and AF20 somatic mutation products.

4:34pm October 17th 2018 via Hootsuite Inc.

Konigshofer #ASHG18 Also notes 'ref sequence info provided by a vendor is acceptable'. NGS for GM24395 (NIST GIAB materials) wasn't >500x

4:30pm October 17th 2018 via Hootsuite Inc.

Konigshofer #ASHG18 Within the assay - heating, sonication, pol errors, even BSA may have bovine DNA in it (!)

4:27pm October 17th 2018 via Hootsuite Inc.

Konigshofer #ASHG18 Reviews Seracare's offerings for mutation mixes, cell-free DNAs, fusion RNAs. Intro to ccfDNA; only 1K cells from 5ng.

4:20pm October 17th 2018 via Hootsuite Inc.

Yves Konigshofer from @SeraCare at the Agilent workshop: "What reference materials can tell you about your assay" #ASHG18

4:17pm October 17th 2018 via Hootsuite Inc.

Gunter #ASHG18 Points to this '18 ref https://t.co/cFq4Xm51Kd how Scherer's group communicates complex ASD information in a sensitive way

3:22pm October 17th 2018 via Hootsuite Inc.

Gunter #ASHG18 Autism Speaks and Google's research project - named it MSSNG and got backlash.

3:20pm October 17th 2018 via Hootsuite Inc.

Gunter #ASHG18 Can also look at data in new ways, showing areas of overlap. Need to stay sensitive to social/political context.

3:19pm October 17th 2018 via Hootsuite Inc.

Gunter #ASHG18 medRxiv - going live soon, preprint server for health sciences. Not peer reviewed, openly accessible. Disclaimer in red.

3:17pm October 17th 2018 via Hootsuite Inc.

Gunter #ASHG18 Story Collider, Dance your PhD, Memes (!) "disclaimers apply"

3:16pm October 17th 2018 via Hootsuite Inc.

Gunter #ASHG18 '14 PNAS https://t.co/DHorym4xtl 'Science communication as political communication'. "Get creative and explore new options"

3:15pm October 17th 2018 via Hootsuite Inc.

Gunter #ASHG18 Points to this AAAS Public Engagement model - many fields moving in this direction of engagement https://t.co/6TrPsXQHK6

3:14pm October 17th 2018 via Hootsuite Inc.

Gunter #ASHG18 Quotes from this NYT https://t.co/toXZkv2w4F White supremacists chugging milk and geneticists are alarmed.

3:12pm October 17th 2018 via Hootsuite Inc.

Gunter #ASHG18 Points to a 23andMe literacy infographic https://t.co/DFoXl9gsze 63% of Americans do not know DNA controls cell fn

3:11pm October 17th 2018 via Hootsuite Inc.

Chris Gunter (Emory) The imptc of communicating science any way you can #ASHG18

3:09pm October 17th 2018 via Hootsuite Inc.

RT @ldoroud: Genomic literacy for everyone: How to talk to the public? #ASHG18 @girlscientist how to measure if we have achieved genomic li…

3:08pm October 17th 2018 via Hootsuite Inc.

RT @SeraCare: At #ASHG18? Our very own Yves Konigshofer, Director of Technology Development, is talking about what reference materials can…

11:20am October 17th 2018 via Hootsuite Inc.