Haber: Idea - serial monitoring for higher liver CTC-score, AFP, +/- liver ultrasound. As a screen need very high sens/spec assays #AACR17
10:56am April 4th 2017 via Hootsuite
Haber: Shows AUC of 0.8 for ROC of untreated HCC. For early detection: AFP and CTC-score together can give orthogonal higher det rt #AACR17
10:55am April 4th 2017 via Hootsuite
Haber: Liver cancer - HCC 80-90% in cirrhosis, 0.5% to 8%/yr. 200M at high risk from chronic Hep B. https://t.co/ABsLUDnT7U #AACR17
10:53am April 4th 2017 via Hootsuite
Haber: Showing markers that show up during progression of CTC-derived markers in prostate cancer. #AACR17
10:51am April 4th 2017 via Hootsuite
Haber: Now showing 'do not post' data - #AACR17 poster abstract from yesterday: https://t.co/33ic7dAW6y
10:48am April 4th 2017 via Hootsuite
Haber: '13 Science https://t.co/4Wjsgp9lzh ref on prostate cancer CTC work. After single-cell iChip enrichment, char, then sc cDNA #AACR17
10:46am April 4th 2017 via Hootsuite
Haber: Selecting single CTCs via color, then char by RNA-Seq. Now doing ddPCR from single cells. For prostate CTCs, 8-20 markers #AACR17
10:44am April 4th 2017 via Hootsuite
Haber: Acquired HER2 heterogeneity. Janssen and MGH commercializing technology. Next work: toward RNA-based diagnostics. #AACR17
10:42am April 4th 2017 via Hootsuite
Haber: Shows drug sens of cultured CTCs. Then dynamic equilibrium between cell states. HER2+ acq '16 ref https://t.co/RR0cxvE0Vi #AACR17
10:40am April 4th 2017 via Hootsuite
Haber: Can be cultured ex-vivo, 'as few as 200 cells' '14 ref https://t.co/7anICCqYES and shows new muts appearing during trtmt #AACR17
10:39am April 4th 2017 via Hootsuite
Haber: Shows instrument, cells from FNA, and staining of melanoma CTCs. Can monitor longitudinally '13 ref https://t.co/tPwx4hPeP3 #AACR17
10:37am April 4th 2017 via Hootsuite
Haber: Then inertial focusing, then magnetophoresis. Now a CTC-iChip is fixed - 3 different regions, 10mL blood/h up to 30mL #AACR17
10:36am April 4th 2017 via Hootsuite
Haber: Working with Toner of MGH, the iChip '13 ref https://t.co/izCxWhi8OH Anti-CD45 mag beads; hydrodynamic sorting... #AACR17
10:35am April 4th 2017 via Hootsuite
Haber: Intravastation from primary Noninvasive monitoring, and potential for early detection #AACR17
10:34am April 4th 2017 via Hootsuite
Daniel Haber (Mass Gen MA) RNA-based analysis of circulating tumor cells #AACR17
10:32am April 4th 2017 via Hootsuite
Nelson: 'And some of you will figure this out.' #AACR17
10:04am April 4th 2017 via Hootsuite
Nelson: Of smokers 16% will get cancer; exposures 80%, inheritance 40%, replication as many as 65%. 185%? #AACR17
Nelson: Per cell division, about 5-10 bases are mutated per cell division. Shows figure from '15 ref https://t.co/kr7LxPDSBv #AACR17
10:03am April 4th 2017 via Hootsuite
Nelson: Shows collard greens: should be a superfood. 'The best way to cook greens is not in bacon grease' #AACR17
10:01am April 4th 2017 via Hootsuite
Nelson: #AACR17 Data from restaurant meat mutagens '00 ref https://t.co/8SeoY8zKLI
10:00am April 4th 2017 via Hootsuite
Nelson: Obesity rates - sobering, map of BMI >30 in the US. Overcooking, charbroiling creates carcinogens. Heterocyclic amines #AACR17
9:58am April 4th 2017 via Hootsuite
Nelson: 'Stop Smoking!' - no question it causes cancer. Diet: most what we know comes from questionnaires; a tricky question #AACR17
9:57am April 4th 2017 via Hootsuite
Nelson:Environment vs inheritance '06 WHO ref https://t.co/81usyoNyuj data of Japanese in Japan vs Japanese in the US and cancer #AACR17
9:56am April 4th 2017 via Hootsuite
Nelson: 44.7k Scandinavian twin pairs, Prostate ca 42%, CR 35%, Breast 27% evidence '00 ref https://t.co/lkWOsFYKCS #AACR17
9:55am April 4th 2017 via Hootsuite
Nelson: What causes cancer in people? breathing, eating, drinking, parents, bad luck,.. hints from genetics of twins #AACR17
9:53am April 4th 2017 via Hootsuite
Nelson: Fast forward to HGP. 'Each one of you are 99.9% identical'. >3M differences, cancers have at least 10K mutations each #AACR17
9:51am April 4th 2017 via Hootsuite
Nelson: Normal cells have genes that suppress cancers '69 Nature https://t.co/AmqHDCoL6X #AACR17
Nelson: Shows gag, env, pol genes: the cancer gene derived from a normal host gene. Src gene: the idea of defective oncogenes #AACR17
9:49am April 4th 2017 via Hootsuite
Nelson: RSV cancer gene char by Varmus and Bishop, 'an inelegant time for dress' commenting on their attire in the photo #AACR17
9:48am April 4th 2017 via Hootsuite
Nelson: #AACR17 Shows chromosome stain from 1966 ref https://t.co/wUBGux7yiW Viruses - shows image from Rous 1911 https://t.co/VTsLtDm7Wl
9:47am April 4th 2017 via Hootsuite
Nelson: Early 1900's: Boveri speculated chromosomes carry genetic material, cancers viewed with abnormal chromosomes. #AACR17
9:44am April 4th 2017 via Hootsuite
Nelson: Virchow in the 1800's: activation of dormant cells; caused by irritation (inflammation) in the tissues. 'Chronic irritation' #AACR17
Nelson: Hippocrates - carcinos; Celsus translated carcinos to cancer; Galen applied oncos for tumors, from Greek for mass. #AACR17
9:43am April 4th 2017 via Hootsuite
Nelson: Prostate cancer back to Egypt - 2nd oldest cancer case 2,250 years ago. Edwin Smith Papyrus: Imhotep describing breast ca #AACR17
9:41am April 4th 2017 via Hootsuite
Nelson: Outline - what is cancer (hallmarks), and what causes cancer (genetics) #AACR17
9:40am April 4th 2017 via Hootsuite
Nelson: His disclosures - 'I'm as corrupt as anybody, here's a list of how I've failed ot get rich' (Ha!) #AACR17
9:39am April 4th 2017 via Hootsuite
William Nelson (Johns Hopkins MD) Understanding Cancer (overview for HS students here at #AACR17)
9:38am April 4th 2017 via Hootsuite
Davidson: The connection between lab and clinic 'was so energizing for me'. So many ways to contribute - 'we're counting on you' #AACR17
9:36am April 4th 2017 via Hootsuite
Davidson: #AACR17 She participated in a Walter Reed summer program; from undergrad, to medical school, to breast cancer research.
9:34am April 4th 2017 via Hootsuite
Nancy Davidson #AACR17 President - as Winston Churchill HS grad, she asked about area students. 'This can be you too."
Showing intro video at #AACR17 with a group of motivated area high-school future cancer researchers https://t.co/9cX3MntfoK
9:25am April 4th 2017 via Hootsuite
Attending a neat #AACR17 program "The conquest of cancer and the next generation of cancer researchers" for area high-school students
9:23am April 4th 2017 via Hootsuite
Q: Avail of MS Score tool? Wu: Published last month, lots of interest. Ref: https://t.co/f4QBVDrjLB Poster session in AM Section 35 #AACR17
7:46am April 4th 2017 via Hootsuite
Q: Average response of the 20 epitopes/pt? Wu: CD4, about 4, CD8, about 2 #AACR17
7:43am April 4th 2017 via Hootsuite
RT @SeraCare: Check out our latest research in the #AACR17 poster sessions! https://t.co/YZNQgFkJMD https://t.co/HkQJTk4xLd
7:42am April 4th 2017 via Hootsuite
Q: MS Score cp to NetMHCpan quadrants? Wu: Affinity does not equal processing/presented. May generate responses but not productive #AACR17
7:41am April 4th 2017 via Hootsuite
Q: How were new reading events caused? Wu: Used DNA-level alterations. NeoORFs from indel events. RNAseq confirmed, splicing unk #AACR17
7:36am April 4th 2017 via Hootsuite
Wu: Showed data that their predictor rules work better. Concl.: NGS enables systematic mining for potential neoAGs #AACR17
7:35am April 4th 2017 via Hootsuite
Wu: Can build a new predictor using peptide features only, combine with gene exp, cleavability, hidden network modeling #AACR17
7:33am April 4th 2017 via Hootsuite
Wu: Looked at gene expression and binding affinity; good predicted binding but low exp, or the opposite, all present as epitopes #AACR17
7:32am April 4th 2017 via Hootsuite
