Allison: 3y K-M flattens out - 20-22% alive after 10y. Why not higher? Showed PD-L1 induced by gamma-interferon #AACR17
8:29am April 3rd 2017 via Hootsuite
Allison: Showed 10y later, lung tumor free (16y later, single injection). Shows K-M NEJM '10 https://t.co/1mWCnwIvn2 #AACR17
8:27am April 3rd 2017 via Hootsuite
Allison: Many adverse advents are inflammation, controlled by steroids. Longest survivor - showed May '01 after IL-2 progression #AACR17
8:26am April 3rd 2017 via Hootsuite
Allison: Medarex made first human antibody to CTLA-4 (ipilimumab) >70K pts treated to-date; objective response in many tumor types #AACR1
8:25am April 3rd 2017 via Hootsuite
Allison: T-cells proliferate; tumor cells have plenty of antigen, CTLA-4 accumulates to stop the T-cells. #AACR17
8:24am April 3rd 2017 via Hootsuite
Allison: Immune checkpoint blockade - not targeting cancer cells; no cytokines to turn 'on' immune; just released activity #AACR17
8:21am April 3rd 2017 via Hootsuite
Allison: From Ipilumumab 2011, took 3 years; 2 in '14; 5 in '15; 5 in '16; 3 in '17 so far #AACR17
8:20am April 3rd 2017 via Hootsuite
James Allison (MD Anderson TX) Immune checkpoint blockade in cancer therapy: insights, opportunities and prospects for ucres #AACR17
8:18am April 3rd 2017 via Hootsuite
MT @cancerassassin1: Yesterday's #AACR17 plenary talk by Dr Vogelstein is freely available to watch online: https://t.co/7ebdvGFoKK
8:11am April 3rd 2017 via Hootsuite
Contag: Machine learning used to improve as they go. Data storage a challenge. At some point they have to erase it. #AACR17
7:50am April 3rd 2017 via Hootsuite
Q: Data storage, processing? Contag: Stitching is software by military/police for robotic data collection of buildings #AACR17
7:49am April 3rd 2017 via Hootsuite
Q: How to control for movement? Contag: Can pull a vacuum to hold still, prefer to make the optics, system faster #AACR17
7:47am April 3rd 2017 via Hootsuite
Contag: Disclosure - company 'PixelGear' Long list of acknowledgements. #AACR17
7:45am April 3rd 2017 via Hootsuite
Contag: Staining - the goal is to 'get rid of glass slides' to guide the pathologist. Can overlay molecular markers #AACR17
7:44am April 3rd 2017 via Hootsuite
Contag: Able to translate multi-color fluorescence to H&E simulation. Entire colon, a 'Google Earth pathology' #AACR17
7:43am April 3rd 2017 via Hootsuite
Contag: 2-3 um res, fluorescence imaging. $2.5K in parts instead of $70K, thanks to an ingenious student. #AACR17
Contag: Microscopes in the body - req FDA approval. What about point-of-care? Wide-field microscope, multispectral, filterless #AACR17
7:42am April 3rd 2017 via Hootsuite
Contag: Particles not FDA-approved, although discussions underway. Able to show xenograft pig model data #AACR17
7:41am April 3rd 2017 via Hootsuite
Contag: Aiming for 1mm pixel res. Able to get a 3d representation of the topology; using the Raman noise instead of the signal #AACR17
Contag: Shows 6 separate dyes, a circumferential Raman scope, each of six colors in a circulating fashion (approx size of colon). #AACR17
7:38am April 3rd 2017 via Hootsuite
Contag: Shows spectrum of Raman shift; sharp peaks; can deconvolute. '09 PNAS https://t.co/58nO1d6aHS Want colon imaging in 10' #AACR17
7:35am April 3rd 2017 via Hootsuite
Contag: Washing unbound probe in-vivo also problematic. Have now moved to nanoparticles - surface-enhanced Raman scattering #AACR17
7:34am April 3rd 2017 via Hootsuite
Contag: Small lasers, uPMTs. Shows spectral overlap of different fluor dyes. For single cells is fine; but in-vivo only 2 or 3 #AACR17
7:32am April 3rd 2017 via Hootsuite
Contag: Caled a 'smart jewelry' project - DAC-array to 'smart bracelet' - mobile processing, look at indiv blood vessels #AACR17
7:31am April 3rd 2017 via Hootsuite
Contag: Shows staining of different dyes; 488nm, 560nm, 680nm dyes. Indicates detection of individual CTCs #AACR17
Contag: Targeting a 50um blood vessel; calc of blood flow, math indicates too low a volume. Thus 'wearable flow cytometers' #AACR17
7:30am April 3rd 2017 via Hootsuite
Contag: Imaging thru skin: in mouse ear, shows dye flowing through vessels in real-time. Should be able to detect flow thru vessels #AACR17
7:29am April 3rd 2017 via Hootsuite
Contag: (Thus - count CTCs in-vivo!) Microscope design is a line-scan (instead of prior optical system, a point scan) #AACR17
7:28am April 3rd 2017 via Hootsuite
Contag: Use a microscope for a transect scan - a blood vessel in cross-section; label not only the tumor, but also CTCs w/a dye #AACR17
Contag: And in-line microfluidics. Needed fiducials to determine where tumor is located; uses vasculature as a 3D map. #AACR17
7:27am April 3rd 2017 via Hootsuite
Contag: A resection tool in a microscopic device - 2nd port for 'pulsed electron avalanche knife' (PEAK) #AACR17
7:26am April 3rd 2017 via Hootsuite
Contag: Wanted to use it for medulloblastoma - pediatric brain tumor, use GFP-labeled mAb, VEGFR1 mAb staining of tumor margin #AACR17
7:25am April 3rd 2017 via Hootsuite
Contag: Shows collection of 5 parts - 'putting them in a jewelry box made sense'. One shown w/suture holes (for a mouse model) #AACR17
7:24am April 3rd 2017 via Hootsuite
Contag: Made of nickel, can snap together, in the $100's or $10's range. Shows engineering drawing, dual axis, alignment #AACR17
7:23am April 3rd 2017 via Hootsuite
Contag: 3mos, several $100K to build. Micromachining to lithography - 2D 'old technology' making watch parts. 'LIGA' #AACR17
7:22am April 3rd 2017 via Hootsuite
Contag: Able to combine fields of view - camera, wide-field fluorescence, microscope with multispectrum #AACR17
7:21am April 3rd 2017 via Hootsuite
Contag: Targeting accessible organs, hollow organs, and surgically-accessed organs. Shows video - find bright stained spot... #AACR17
7:20am April 3rd 2017 via Hootsuite
Contag: Custom manipulator controls; optically able to do multispectral microscopy, a micromachined scanning device 1.5mm #AACR17
7:19am April 3rd 2017 via Hootsuite
Contag: Shows endoscope device, w/both macroscopic and microscopic field of view. Advances in optical SW enables stitching of images #AACR17
7:18am April 3rd 2017 via Hootsuite
Chris Contag (Stanford CA) The future of cancer imaging #AACR17
7:17am April 3rd 2017 via Hootsuite
@JMill_tweets @shenhui1986 Thanks @shenhui1986 for the laugh!
5:17am April 3rd 2017 via Hootsuite in reply to JMill_tweets
RT @JMill_tweets: April fools joke in presentation, nice #AACR17 https://t.co/J51KMNG5Rb
10:35pm April 2nd 2017 via Hootsuite
MT @robertmarc60: Many have wrecked on the shoals of neurosci https://t.co/epuFV6OUG1 Sld 4 https://t.co/bxEG8SSeqn https://t.co/lwbjlBIro5
9:40pm April 2nd 2017 via Hootsuite
dbGaP asks for users' feedback | Repositive https://t.co/RmF3YL83Z8
8:50pm April 2nd 2017 via Hootsuite
RT @ "Collectively, rare diseases are not rare. #raredisease https://t.co/MdCZUmxigv"
7:45pm April 2nd 2017 via Hootsuite
DePristo: 54 doctors, '16 JAMA https://t.co/gQZlkrZytk F-score 0.95 human 0.91. 'Lives up to the hype' commentary #AACR17
2:01pm April 2nd 2017 via Hootsuite
DePristo: Challenge - ophthalmologist graders (on a 5-point scale from none to proliverative), and showing consistency not great #AACR17
2:00pm April 2nd 2017 via Hootsuite
DePristo: Onto diabetes and retinopathy - healthy vs diseased images of the retinal fundus. Looking for hemorrhages. #AACR17
1:59pm April 2nd 2017 via Hootsuite
DePristo: Shows human error rate is higher (around 5%) cp to computers in '15 (below the human error rate) ImageNet Challenge #AACR17
1:56pm April 2nd 2017 via Hootsuite
DePristo: Cat vs Dog: have been working on it for >4y. Shows performance of errors from '10 at 25% error; 2012 15%; '14 7% #AACR17
1:55pm April 2nd 2017 via Hootsuite
