Butte: Shows more complex pathway - from heart failure to lung disease to sepsis. Or via hypertension to sepsis. #PMWC17
1:51pm January 24th 2017 via Hootsuite
Butte: Wants to build maps on how people get sick and die. Say cirrhosis: alcohol-induced mental disorder, cirrhosis, etc. #PMWC17
1:50pm January 24th 2017 via Hootsuite
Butte: Building a UC-wide data warehouse (15M pts, about 4% of US pop.) Lists many options w/raw clinical data (mobile, transplant) #PMWC17
Butte: 2y at UCSF computional health sciences https://t.co/Zd6DKzYlaA New building in Mission Bay; next: clinical data EHR #PMWC17
1:49pm January 24th 2017 via Hootsuite
Butte: May be a new world: to do virtual clinical trials, testing markers for CDx, much possible with this. #PMWC17
1:47pm January 24th 2017 via Hootsuite
Butte: NuMedii also pushing psoriasis R&D. Next open-data effort: clinical trials. Repository Immport https://t.co/8w27UjFhe4 #PMWC17
Butte: Shows unpublished data on psoriasis. Using a '60's-era diuretic drug (no longer used). Shows triple-stained IHC #PMWC17
1:45pm January 24th 2017 via Hootsuite
Butte:15 mos from computer prediction, NuMedii for SCLC using psych drug and working in mouse now in clin trials #PMWC17
1:43pm January 24th 2017 via Hootsuite
Butte: Shares Carmenta's story startup to acquisition by Progenity https://t.co/4z8uCGc0RL Used public data microarray gene sig's #PMWC17
1:42pm January 24th 2017 via Hootsuite
Butte: Points to this Wired piece w/a cover title 'The End of Science' due to the data deluge https://t.co/NOMkwGtwTt #PMWC17
1:39pm January 24th 2017 via Hootsuite
Atul Butte (UCSF) Driving disease understanding and treatment via a centralized data warehouse #PMWC17
1:37pm January 24th 2017 via Hootsuite
Q: GINA and impact? Mattison: Book (Amazon: https://t.co/Ovq3l0RtPc ) "Lost in Translation" addresses this problem #PMWC17
12:59pm January 24th 2017 via Hootsuite
Mattison: Insight example: spleen transplant, pneumococcal vaccination. 2w vs 3h to find the same patients. #PMWC17
12:56pm January 24th 2017 via Hootsuite
Mattison: A myriad permutations of workflows; improving the process. Little value in retrieving data today; high cost of data entry #PMWC17
12:55pm January 24th 2017 via Hootsuite
Mattison: EHRs is the system 'everybody loves to hate' like cafeteria food. But nobody is advocating going back to paper. (!) #PMWC17
12:54pm January 24th 2017 via Hootsuite
Dilks: Determine where the high-value data is captured within EMRs. What NL processing tech, for valuable data #PMWC17
12:52pm January 24th 2017 via Hootsuite
Q: With EHRs not being efficient, what do you see? (MD Anderson https://t.co/E9GRR49Cdv ) Urban: Link at PoC of benefit to pts #PMWC17
Dilks: Pts quickly find out - this is the way it is going, patients becoming empowered. #PMWC17
12:49pm January 24th 2017 via Hootsuite
Urban: Pts are told 'don't see doctor Google' but of course they do anyway. #PMWC17
Diamond: Where the physician was incorrect. Role of consumers? Urban: Parents do request healthy baby testing. #PMWC17
12:44pm January 24th 2017 via Hootsuite
Diamond: Public's thirst for genomic data exceeds the physician's expertise. Ex: pulmonary fibrosis. 'Can I get a genetic test?' #PMWC17
12:43pm January 24th 2017 via Hootsuite
Mattison: Moffit's video about risks/rewards for genomic sequencing - 100% participation. We need to promote informed consent etc #PMWC17
12:42pm January 24th 2017 via Hootsuite
Mattison: (Asks for show of hands who has donated their genome for sequencing) There are real risks for this data, consent #PMWC17
12:41pm January 24th 2017 via Hootsuite
Mattison: Refers to this '16 Fast Company https://t.co/uxtb0sB7ih about BRCA testing and insurance options. #PMWC17
12:40pm January 24th 2017 via Hootsuite
Dilks: What HCA is trying to do - enabling physician w/info, and enabling pts to act on this. #PMWC17
12:34pm January 24th 2017 via Hootsuite
Dilks: With a partner with a strong response, people will learn and start demanding access to tests and trials. Exciting convergence #PMWC17
12:33pm January 24th 2017 via Hootsuite
Mattison: From the public perception standpoint, 'I don't think we're that far away'. #PMWC17
12:32pm January 24th 2017 via Hootsuite
Mattison: What 'tipping point' event for a genetic disorder to justify widespread screening? Sth like sickle-cell and curable? #PMWC17
Dilks: There are reimbursement challenges, grapple with the same problem/issues as others. Tests are ordered; unclear who foots bill #PMWC17
12:29pm January 24th 2017 via Hootsuite
Urban: Now how better to screen for decision support? Who to test, and why, will realize cost savings. #PMWC17
12:27pm January 24th 2017 via Hootsuite
Q: Addiction medicine, genetics, self-funded, where does research go? Urban: Very expensive cp to genetics for prognosis or Dx a win #PMWC17
Urban: For the ave pediatrician? What about later at 6mos or 12mos? A 20-pg report, what to do next w/o academic ctr specialists? #PMWC17
12:26pm January 24th 2017 via Hootsuite
Urban: Negative biopsy, sent out WES, rare disease assoc'd w/gypsies, from a caucasian family. #PMWC17
12:24pm January 24th 2017 via Hootsuite
Q: Speed of info to PoC? Urban: What test to send? (Was something missed?) Liver failure, unk cause, common in neonates. #PMWC17
12:23pm January 24th 2017 via Hootsuite
Mattison: Ontology diversity: dozens of overlapping, conflicting ones. May need perhaps 6; want 'patients like mine' #PMWC17
12:19pm January 24th 2017 via Hootsuite
Q: Standards? Mattison: 2 reasons why there are many stds: ontology based upon spec design goals (drug res vs. clin care, others) #PMWC17
12:18pm January 24th 2017 via Hootsuite
Dilks: With Genospace tool, can bring in criteria to filter pts as they come in. #PMWC17
12:17pm January 24th 2017 via Hootsuite
Dilks: HCA does early-phase trials. Molecular requirement is only growing. How to educate? How to bring EMR data in? Genomic data? #PMWC17
12:16pm January 24th 2017 via Hootsuite
Diamond: One pt with 'suitable for hospice' by family doctor, and then looked up clinical trials options... #PMWC17
12:15pm January 24th 2017 via Hootsuite
Urban: And how to explain results back to the family? Next steps for treatment? #PMWC17
12:14pm January 24th 2017 via Hootsuite
Urban: Neonatal: can suspect something, send it out, get back a 'clunky PDF'. Challenge: what beyond first-level testing? #PMWC17
Mattison: Getting to behavioral info - for the individual to be better-informed. #PMWC17
12:13pm January 24th 2017 via Hootsuite
Mattison: The necessity of convergence - interpretable, actionable info is 'huge'. And decision-support Direct to Consumer #PMWC17
12:12pm January 24th 2017 via Hootsuite
Mattison: Similar to Kaiser's problem - physicians complain about unstructured PDF data, which they've solved. But training... #PMWC17
Dilks: Very hard for these physicians to determine what to do next. Level of training, sophistication, determines what they do next #PMWC17
12:11pm January 24th 2017 via Hootsuite
Q: Where are clinicians today? Dilks: Have >500 clin trials, tests are being ordered from community hospitals, figuring it out #PMWC17
12:10pm January 24th 2017 via Hootsuite
Panelists (con't): Amy Urban (UPitt MC) - neonatal med, new technology for UPMC, Joel Diamond (2bPrecise) #PMWC17
12:08pm January 24th 2017 via Hootsuite
Panelists: Holli Dilks (Sarah Cannon Res Inst/HCA) - biomarker strategies; John Mattison (Kaiser) - health IT, integrative care; #PMWC17
12:07pm January 24th 2017 via Hootsuite
Halevy: Showed work they are doing with the NCI/NIH both somatic and germline. #PMWC17
12:05pm January 24th 2017 via Hootsuite
Halevy: Bringing actionable machine-readable object for treatment, at POC (2bPrecise is a division of Allscripts) #PMWC17
12:04pm January 24th 2017 via Hootsuite
