Stem-cell scientists redefine how blood is made, toppling conventional 'textbook' view from 1960s - ScienceDaily https://t.co/sw2L64fzza
4:31am November 9th 2015 via Hootsuite
RT @TheAtlantic: Programmers: Stop calling yourselves engineers https://t.co/UJgs7AjDF1 https://t.co/ipkG3Fx8tJ
9:45pm November 8th 2015 via Hootsuite
RT @EricTopol: How data sharing is changing some #cancer clinics https://t.co/22gycnODT4 @NatureOutlook https://t.co/BOeUt6pCpu https://t.c…
8:59pm November 8th 2015 via Hootsuite
Past failures position iRobot to lead consumer robotics industry | Beta Boston https://t.co/YOnjcEUNiO
8:45pm November 8th 2015 via Hootsuite
What teachers just don’t get about homework - Boston Globe https://t.co/SIc6rDfG9X
7:45pm November 8th 2015 via Hootsuite
The ice dam cometh. Are you ready? - The Boston Globe https://t.co/wjl7mTKapR
6:45pm November 8th 2015 via Hootsuite
How to fall in love with Los Angeles - The Boston Globe https://t.co/LBvQ93D0K5 As a Santa Monica native, I approve of this.
5:35pm November 8th 2015 via Hootsuite
I Am Paying for Your Expensive Medicine, a PCSK9 inhibitor - New York Times https://t.co/OJMvxCBkC9
4:30pm November 8th 2015 via Hootsuite
Intrinsic Quality Values | dazzlerblog https://t.co/3s0VuEf0kb via @TheGeneMyers
3:30pm November 8th 2015 via Hootsuite
So well put. RT @kevverage: @Camburly @RogueCoder250 There's nothing I can do about those who are determined to not understand
3:15pm November 8th 2015 via Hootsuite
RT @NatureNews: A London lab is deploying every technology to understand infant brains https://t.co/t3YgAFceNI https://t.co/21hliGeeyG
2:15pm November 8th 2015 via Hootsuite
RT @drbachinsky: Hands on experience with Oxford Nanopore MinION https://t.co/39ZwKEU6kB
1:10pm November 8th 2015 via Hootsuite
RT @SteveStuWill: Intelligence is around 50% heritable... in chimps https://t.co/2kwJUj9FqF
12:10pm November 8th 2015 via Hootsuite
GWAS of host microbiota RT @DrKhouryCDC: Is the gut microbiome heritable? Via @PLOSONE. https://t.co/UHFbnaoCCu https://t.co/SoLzUZ6MuH
11:35am November 8th 2015 via Hootsuite
RT @rahman_nazneen: Stem cell reverses infertility after cancer in mice. Human studies planned. https://t.co/7WuMshJUtO
10:35am November 8th 2015 via Hootsuite
MT @dgmacarthur: Another great ex. of using naturally occurring human "knockout" variants to decipher gene function: https://t.co/s1IP4L6gwi
9:30am November 8th 2015 via Hootsuite
.@drbachinsky It was interesting to see @nanopore as an exhibitor at #AMP2015 - many papers coming out for infectious disease using it.
9:03am November 8th 2015 via Hootsuite in reply to drbachinsky
One neat idea for conferences MT @Mark_RWD: 10 Ways to Use #Twitter Lists Infographic https://t.co/N9qElck7EJ https://t.co/VHpkti1Ocy
8:20am November 8th 2015 via Hootsuite
.@ariv2013 Thank you for the kind #AMP2015 word! Next year in Charlotte it is!
8:32pm November 7th 2015 via Hootsuite in reply to ariv2013
Great to meet everyone at #AMP2015 - see you next year!
4:41pm November 7th 2015 via Hootsuite
Hansen: Gene, RNA or protein product; mentions list of systems for beta-lactamases. Goes through them: Cepheid, Verigene... #AMP2015
3:42pm November 7th 2015 via Hootsuite
Hanson: Phenotypic testing for ESBL, AmpC and carbapenamases have variable susceptibility; 8 diff beta-lactam resistance mech's (!) #AMP2015
3:41pm November 7th 2015 via Hootsuite
Hanson: 2 new gram-neg drugs; 'we can't 20 years to evaluate emergence of resistance'. Need molecular analysis to detect resist. #AMP2015
3:38pm November 7th 2015 via Hootsuite
Hanson: Needed to track antibiotic prescribing and resistance patterns. Molecular ID of resistance mechanism #AMP2015
3:37pm November 7th 2015 via Hootsuite
Hanson: Clinicians, nurses, pharmacists, staff need education on resistance patterns, optimal prescribing. #AMP2015
3:36pm November 7th 2015 via Hootsuite
Nancy Hanson (Creighton U) 20-50% of all antibiotics in the US prescribed in the US acute care are unnecessary/inappropriate. #AMP2015
Religious children are meaner than their secular counterparts, study finds | World news | The Guardian https://t.co/fjjwCA6Aoa
2:40pm November 7th 2015 via Hootsuite
Li: (Presents draft versions of somatic var categories, as well as subdivisions w/in each category of therapy, dx, or prognostic) #AMP2015
12:24pm November 7th 2015 via Hootsuite
Li: Ref 2014 Van Allen https://t.co/jS4fcTpNwI and their classification system #AMP2015
12:22pm November 7th 2015 via Hootsuite
Li: It was in the middle (VUS or likely pathological) - a spread of interpretations. Asking oncologists: want to know VUS #AMP2015
12:21pm November 7th 2015 via Hootsuite
Li: Working off of ACMG guidelines https://t.co/jNtMNerWCV for germline, how to extend to somatic? Had a 'pop quiz' var challenge #AMP2015
12:19pm November 7th 2015 via Hootsuite
Li: Major disclaimer: Draft Work In Progress. Variant categories and reporting: aim to gather feedback here at #AMP2015
12:17pm November 7th 2015 via Hootsuite
Nikiforova: Trends can help put guidelines and best practice document. #AMP2015
12:16pm November 7th 2015 via Hootsuite
Nikiforova: All 5 ex. rpts have category for VUS. Overall 1) actionable, 2) potentially pathogenic or actionable, 3) VUS, 4) benign #AMP2015
12:15pm November 7th 2015 via Hootsuite
RT @AMPath: Burgess: The #FDA has significant work to do before moving to final guidelines. #AMP2015 @michaelcburgess
12:13pm November 7th 2015 via Hootsuite
Nikiforova: Finishes with a few example reports, categories of variant types. #AMP2015
Nikiforova: 30% do not report w/ genes do not meet QC std (i.e. <500x). 70% do put it in w/disclaimer #AMP2015
12:12pm November 7th 2015 via Hootsuite
Nikiforova: Oncologists may have difficulty w/interpretation if AF info is not provided. #AMP2015
12:11pm November 7th 2015 via Hootsuite
Nikiforova: 50% do not report allele frequencies; impt to know b/c it may affect treatment, prognostic, biology of tumor #AMP2015
Nikiforova: Databases: MyCancerGenome almost 80%. 90% do not use commercial template for reporting #AMP2015
12:10pm November 7th 2015 via Hootsuite
Nikiforova: MAF cutoff - majority use 1%. Almost 80% report VUS in their report. 30% likely benign too. #AMP2015
12:09pm November 7th 2015 via Hootsuite
Nikiforova:80% labs do not require normal along w/tumor specimen. What db then used? TGP, dbSNP. Others is NHLBI Exome, custom. #AMP2015
12:05pm November 7th 2015 via Hootsuite
Nikiforova: Literature searches - vast majorit for freq in cancer, functional stuides for activating / LoF. Also: PGx #AMP2015
12:04pm November 7th 2015 via Hootsuite
RT @DrJamesPrescott: Rep Burgess: FDA can't define the problem they are trying to solve. #AMP2015
12:02pm November 7th 2015 via Hootsuite
Nikiforova: Det limit: 85% were 5%. But comments: <1% for cfDNA. Some 'certain hotspots 2%' #AMP2015
12:01pm November 7th 2015 via Hootsuite
.@GholsonLyon Was told by a friend at Omicia there was a surprising amount of interest in their solution (interpreting clinical WES/WGS).
12:00pm November 7th 2015 via Hootsuite in reply to GholsonLyon
Nikiforova: 80% amplicon-based, 35% hyb capture. >200x depth in 93% of labs. 56% report min depth of >500x #AMP2015
11:59am November 7th 2015 via Hootsuite
Nikiforova: 49% heme. Majority run 26-50 genes for solid tumors / heme. lab-developed and commercial both 60% apiece #AMP2015
11:58am November 7th 2015 via Hootsuite
Marina Nikiforova (U Pitt PA): First time report on the survey, will be published. n=66 technical, n=44 general 83% labs ST panels #AMP2015
11:57am November 7th 2015 via Hootsuite
.@GholsonLyon Yes, Yandell spoke this morning (an early-bird session), Mungall is from Lawrence Berkeley, talking about phenome analysis
11:56am November 7th 2015 via Hootsuite in reply to GholsonLyon
