CM: Shows the DC metro - does the person cleaning actually work there? (!) Precision metagenomics: hosp settings #AGBT
11:16am February 28th 2015 via Hootsuite
CM: A forest fire of the microbiome - after it gets washed. Then repopulated from people. #AGBT
CM: 'Should I ride the subway?' - quotes online comments. 'This is like an ad for Uber' (!) Shows movie of subway cleaned #AGBT
11:15am February 28th 2015 via Hootsuite
RT @illumina: CM: @mason_lab "let's just start looking" http://t.co/h2g7jFEnwm #AGBT15
11:14am February 28th 2015 via Hootsuite
CM: 2010 census data by ancestry, and then can map in their Pathomap data to show movement #AGBT
CM: Mentions this '08 Nature from J Novembre http://t.co/0U1bzoK4Wt connecting genotypes to geography. Also mentions STR markers #AGBT
11:13am February 28th 2015 via Hootsuite
CM: Mus musculus - as much as 8% of all DNA. Human DNA - 'no pants' day missed this year... #AGBT
11:12am February 28th 2015 via Hootsuite
CM: Corrected link to timecourse movie: http://t.co/Z6HsscjhIE #AGBT
11:11am February 28th 2015 via Hootsuite
CM: Look at hourly dynamic risks. Shows a map of ticket machine online her: http://t.co/OKs76dYA9C #AGBT15 h
CM: Flooding traces, antarctic spp. 'Licking subway poles "probably fine" says Expert' (another #scicomm reference) #AGBT15
11:10am February 28th 2015 via Hootsuite
CM: 'The subway looks like skin' - matching to HMP. Log2 of obs/expected. WSJ Interactive map of kimchi http://t.co/QktrAu3OUH #AGBT15
11:09am February 28th 2015 via Hootsuite
Chris Mason, Weill Cornell Med Coll City-Scale DNA Dynamics, Disease Surveillance, and Metagenomics Profiling #AGBT15
11:07am February 28th 2015 via Hootsuite
RT @bioinformer: Great quote from JM Tanner #AGBT15 http://t.co/W40BuFavxI
10:36am February 28th 2015 via Hootsuite
DE: <No twitter activity as the 10K hour rule has been debunked, no matter that Malcolm is his running buddy> http://t.co/wVAwX2V7Zc #
10:18am February 28th 2015 via Hootsuite
David Epstein, ProPublica: Dangerous Dichotomies: How Sports Harm Genetic Research #AGBT15
10:10am February 28th 2015 via Hootsuite
RK: The GNPS website at UCSD: http://t.co/b7d7dMCGgV #AGBT15
RK: Is in transition to UCSD Mentions GNPS - I blogged about other work at UCSD microbiome work here http://t.co/I1OgqnRneE #AGBT15
10:09am February 28th 2015 via Hootsuite
RK: In 10y - applications of DNA seq. Future - 3D PCA software demo, called 'cheetah', can trace phylogeny per treatment #AGBT15
10:06am February 28th 2015 via Hootsuite
RK: In 1-2d, the shift to the healthy state and stays there for months. Look for disruption, healthy state. A 'smart toilet'? #AGBT15
10:03am February 28th 2015 via Hootsuite
RK: Effect of gut microbiome - now onto C.diff. Distribution of microbiomes of the recipient pt vs. donor. Shift dramatic #AGBT15
10:02am February 28th 2015 via Hootsuite
RK: American Gut project: where are you on the map? http://t.co/rXrn5SnBbT $1.1M raised for this project #AGBT15
10:01am February 28th 2015 via Hootsuite
RK: 90% of bacteria on skin 'come from beauty products'. A tremendous impact on skin microbiome #AGBT15
9:59am February 28th 2015 via Hootsuite
RK: Kwashiorkor acute malnutrition, examined effect of microbiome (Science ref: http://t.co/NDqa0i5muq ) #AGBT15
9:58am February 28th 2015 via Hootsuite
RK: Germ-free mice to look at obesity in mice. ob/ob mice, leptin mutants, transplant feces. Data shows it was feces #AGBT15
9:56am February 28th 2015 via Hootsuite
RK: But does this diversity matter? Commercialization potential of obesity: 50% via human genes; 90% via microbiome #AGBT15
9:53am February 28th 2015 via Hootsuite
RK: $173M of HMP is only a fraction of the diversity in adults in geography, age Fig from 2012 Nature http://t.co/XtEBnPP0X1 #AGBT15
9:51am February 28th 2015 via Hootsuite
RK:Traces microbiome of a newborn via this PCA representation: from birth (meconium) through 2.5y #AGBT15
9:49am February 28th 2015 via Hootsuite
RK: Points out differences across body sites - only 10% similarities. #AGBT15
9:46am February 28th 2015 via Hootsuite
RK:HMP - 4.5Tb of sequence data; saved as a graphical PCA plot; each cluster per body site (oral, skin etc.) #AGBT15
9:44am February 28th 2015 via Hootsuite
RK:Also impt for drug responses - acetominophen's effect on liver toxicity depending on microbes in the gut #AGBT15
9:41am February 28th 2015 via Hootsuite
RK: What do our microbes do? Perh why you get more mosquito bits NB: his TED talk Feb 14 online here: http://t.co/fpbLOQeTTR #AGBT15
9:39am February 28th 2015 via Hootsuite
Rob Knight, UnivColorado, Boulder: Dynamics of the Human Microbiome and its Evolving Genomes #AGBT15
9:38am February 28th 2015 via Hootsuite
MF:Q:What abt biofilms? A:Pseudomonas has efflux pumps, Fe-chelating molecules. Still many exported/imported molecules #AGBT15
9:37am February 28th 2015 via Hootsuite
MF:Q:Other bact resistant? A:G+ pathogens seem sensitive (vaginal); broader Q in soil, how do these grow? Perh not growing as fast #AGBT15
9:36am February 28th 2015 via Hootsuite
MF:Q:G+ organisms, potent but resistance? A:Most have mech of host-resistance; say a pump for efflux #AGBT15
9:35am February 28th 2015 via Hootsuite
With MF's opening talk, what a great and fun way to start the day! (From a standing start to 100mph.) #AGBT15
9:33am February 28th 2015 via Hootsuite
MF: They are present in high concentrations, change from indiv to indiv, and are present for years #AGBT15
9:32am February 28th 2015 via Hootsuite
MF: What are the top 10 spp. in your gut? But what about gut metabolites? Busy slide with dozens. There in high conc. #AGBT15
9:31am February 28th 2015 via Hootsuite
MF: What are the microbiota doing to each other; what are they doing to the host? Now metatranscriptomic reads (very few datasets) #AGBT15
9:30am February 28th 2015 via Hootsuite
MF: Thousands of potent drug-like molecules synthesized all around us (!) #AGBT15
MF: Microbiota 'do an end-run - they make these compounds and they are there' #AGBT15
9:29am February 28th 2015 via Hootsuite
MF: Lactocillin ID'd - a potent antibiotic against gram-neg. 'It overturns a paradigm - drug companies dev - FDA app - people' #AGBT15
MF: Thiopeptides from the human microbiota (again Donia et al ref), found mutant vs WT - spectra shows significant. 120L grown up #AGBT15
9:28am February 28th 2015 via Hootsuite
MF: A family of molecules, a 'little bit of biochemical modification by the bacteria' #AGBT15
MF: Found family of BGC's for thiopeptide antibiotics - 13 post-transl mods (!), incl. pyrimidine ring http://t.co/ZtWVyyx85b #AGBT15
9:27am February 28th 2015 via Hootsuite
MF: Three thiopeptide antibiotics, real drugs. Bind 50S subunit, potent against G+ bact. Harms 2008 paper http://t.co/ysV1en2JIB #AGBT15
9:25am February 28th 2015 via Hootsuite
MF: Complex chemically, and how much business it could mean (!!) #AGBT15
9:24am February 28th 2015 via Hootsuite
MF: Ave gut has 599 gene clusters; ave oral cavity, 1,061 gene clusters. Saccharides predominate; well-studied BGC 'are rare' #AGBT15
MF: 44K predicted biosynthetic gene clusters; 14K in known classes; 3.1K BCG's in HMP metagenomic data. #AGBT15
9:23am February 28th 2015 via Hootsuite
MF: Next - ID gene clusters in the microbiome. 3K biosynthetic gene clusters from the HMP (2.3K genomes) http://t.co/FoZnsoXUP4 #AGBT15
9:22am February 28th 2015 via Hootsuite
