Schadt et al RT @DivaBiotech: How do students react to analyzing own genomes in a whole-genome sequencing course? http://t.co/sEUmKAfDMe
9:40pm February 11th 2015 via Hootsuite
RT @EBernsteinWSJ: Plus, this story on adorable robot dogs comes with best WSJ dot portrait in ages. http://t.co/nKug5xsQdc http://t.co/wvi…
8:34pm February 11th 2015 via Hootsuite
RT @mochi_wsj: This story on Sony's Aibo toy dogs shows how robot can change people's life, in a good way: http://t.co/bm4UF9IX9f http://t.…
Woman's stool transplant leads to 'tremendous weight gain' - BBC News http://t.co/MuGxz7qWAw
8:30pm February 11th 2015 via Hootsuite
RT @pickover: The loop in this mosaic 2nd cent. Roman theater crosses itself 14 times. Source: http://t.co/szOv1g1n9E http://t.co/IrdlwKsHHX
7:45pm February 11th 2015 via Hootsuite
RT @guardian: Muslim rule and compass: the magic of Islamic geometric design http://t.co/VepDdWFr08 http://t.co/VCAmTtlaJD
6:10pm February 11th 2015 via Hootsuite
Dienekes’ Anthropology Blog: A genetic map of the British population http://t.co/t5DZbMAH5d HT @drbachinsky
5:55pm February 11th 2015 via Hootsuite
Anya Pogharian invents $500 dialysis machine with at-home potential - CBC News http://t.co/pIxWSFr9PV
4:45pm February 11th 2015 via Hootsuite
.@lisabriercliffe Considering the potential of youth today, it's humbling to this not-quite-old person and inspirational at the same time.
4:25pm February 11th 2015 via Hootsuite in reply to
RT @Megan_BioPharma: Yale's Krumholz just hit the nail on the head. This cohort has to be a membership with patients.@hmkyale #PMINetwork #…
4:01pm February 11th 2015 via Hootsuite
Data Mining Reveals a Global Link Between Corruption and Wealth | MIT Technology Review http://t.co/KHPE3ltAuW HT @drbachinsky
3:40pm February 11th 2015 via Hootsuite
An open letter to Americans who don't believe in science | Corn Corps http://t.co/uE5dcCGRuh
2:25pm February 11th 2015 via Hootsuite
Chanock: Second time in one day - Woodrow's quote about the brains the he could borrow... http://t.co/EMvdlAa3aK #trentlecture
1:57pm February 11th 2015 via Hootsuite
Chanock: The 'Aging Genome': clues to what can be tolerated or selected in cancer. Also impt role in non-cancer disease #trentlecture
1:56pm February 11th 2015 via Hootsuite
Chanock:Large-scale events - age-related work in TCGA data Xie et al http://t.co/KzvD9QikoQ #trentlecture
1:54pm February 11th 2015 via Hootsuite
Chanock: '20% of the men by 60yo have lost their Y-chromosome' (!) #trentlecture
1:53pm February 11th 2015 via Hootsuite
Chanock:Chart of mosaicism by chromosome - most on the ChrX. May be due to inactivation. Y loss may be consequence of aging #trentlecture
Chanock:T21, Turner's syndrome, proteus: mosaicism in the 'extreme' #trentlecture
1:51pm February 11th 2015 via Hootsuite
Chanock:Found 1-2% >50yo with large proportion of blood cells with mosaic events. The 'dynamic genome' - mosaicism history #trentlecture
1:50pm February 11th 2015 via Hootsuite
Chanock:NGS of 'normal' tissues: we may need to face 'sequencing our genomes more than once' due to aging. >100K GWAS smpls #trentlecture
1:49pm February 11th 2015 via Hootsuite
Chanock: Next frontier: the environment and molecular heterogeneity. Credits '>400 collaborators' #trentlecture
1:48pm February 11th 2015 via Hootsuite
Chanock: NHGRI's 'wonderful resource' of ENCODE: PSCA gene for bladder ca. - fn SNP changed expression; humAb to test antiPSCA #trentlecture
1:44pm February 11th 2015 via Hootsuite
Chanock:Important opportunity: for 'precision prevention' #trentlecture
1:41pm February 11th 2015 via Hootsuite
Chanock:100K at high risk of bladder ca. - stopped smoking, 5.4k cases eliminated. At low risk: 1.5K cases #trentlecture
Chanock: Smoking connected to bladder cancer risk - looked at cumulative 30y absolute risk, against 12 SNPs, sig difference #trentlecture
1:40pm February 11th 2015 via Hootsuite
Chanock: For specific cancers - each architecture with unique underlying predispositions. Can explain 40% excess familial risk #trentlecture
1:36pm February 11th 2015 via Hootsuite
Chanock:Perturbation to key pathways of common variants; distinct spaces to rare alleles of damaging drivers #trentlecture
1:34pm February 11th 2015 via Hootsuite
Chanock:Under GWAS peaks - no difference in number or types of somatic mutations cp to random mutations #trentlecture
1:33pm February 11th 2015 via Hootsuite
Chanock:Of 470 distinct GWAS suscept. alleles for >24 cancers: only 25 biologically explained. <5% map to COSMIC as 'drivers' #trentle
1:32pm February 11th 2015 via Hootsuite
Chanock:Strong enough signal to consider whether genetic counseling is needed for testicular cancer. Discovery pushing fwd. #trentlecture
1:30pm February 11th 2015 via Hootsuite
Chanock:Cp with testicular ca. - high familial risk, all seg. toward telomerase regulation, germ cell dev, sex determination #trentlecture
1:29pm February 11th 2015 via Hootsuite
Chanock: Chart of prostate ca markers: of 100's only 2 or 3 survive statistical significance. #trentlecture
1:28pm February 11th 2015 via Hootsuite
Chanock: GWAS chart - 29 cancers, 8% shared raising Q of bias and whether this shared genotypes are real. None ass'd w/outcome #trentlecture
1:27pm February 11th 2015 via Hootsuite
Chanock:GWAS - 'not for the weak of heart' as 'you can be very happy or very depressed' #trentlecture
1:25pm February 11th 2015 via Hootsuite
Chanock:'Famous' chart of rare vs. low freq vs. common variants against effect size: common and uncommon cancers #trentlecture
Chanock:Should we sequence more than TP53? "The answer is of course, yes" #trentlecture
1:24pm February 11th 2015 via Hootsuite
Chanock: Layer on age w/g-type, young onset osteosarcoma has distinct germline genetic etiology. Consider: genetic counseling #trentlecture
Chanock:Sequenced all Li-Fraumeni mutations, looked at Germline TP53. 10% of children, harbored TP53 mut's #trentlecture
1:22pm February 11th 2015 via Hootsuite
Chanock: Germline susceptibility 'not with ILMN, but with @iontorrent, yes other technologies do work' (ha!) of Osteosarcoma #trentlecture
1:21pm February 11th 2015 via Hootsuite
Chanock:Also environmental effects, other modifier genes interact with BRCA w/ other types of cancer that track w/it. #trentlecture
1:19pm February 11th 2015 via Hootsuite
Chanock: In the ~115 genes for germline - BRCA isn't 100% - impt where the mutation takes place; incomplete 'penetrance' #trentlecture
1:18pm February 11th 2015 via Hootsuite
Chanock: Other two quadrants: clinically actionable. ~26 (BRCA1/2, Lynch) at germline. Somatic: TCGA http://t.co/Ee9XOU1pW8 #trentlecture
1:17pm February 11th 2015 via Hootsuite
Chanock: 4 spaces: ~115 cancer syndromes explaining familial clustering; >470 regions of GWAS loci. Somatic (TCGA, COSMIC) #trentlecture
1:14pm February 11th 2015 via Hootsuite
Chanock: 'But we are at odds with industry' - lagging behind with pharmacogenomics (PGx), both a scientific and cultural problem.
1:13pm February 11th 2015 via Hootsuite
Chanock: '69 Li-Frumeni (TP53), '71 Knudsen 'two-hit'. Population-based screening has public-health implications; also etiology and PGx
1:12pm February 11th 2015 via Hootsuite
Chanock: "The Complexity of Genetic Susceptibility to Cancer" How the germline informs cancer. Starts with 1866 Broca and breast ca.
1:09pm February 11th 2015 via Hootsuite
Stephen Chanock @NCIChanock introduced as a 'Renaissance Man', with an undergraduate degree in music (!) http://t.co/mmZmSbDJTS
1:05pm February 11th 2015 via Hootsuite
Pleased to attend! MT @NCIEpiTraining TODAY @ 1pm Dr. Stephen Chanock, Jeffrey M. Trent Lecture in #Cancer Research http://t.co/FdZ6x1noFn
1:02pm February 11th 2015 via Hootsuite
RT @lisabriercliffe: These incredible National Geographic photos were shot by kids | Mashable http://t.co/w1kh7G0uPg
12:45pm February 11th 2015 via Hootsuite
Masys: Concludes with 'somber note' on cybersecurity. Attacks will be a persistent threat. 'Highly intolerant of error' #PMINetwork
11:11am February 11th 2015 via Hootsuite
