RT @genetics_blog: Where Next for Microbiome Research? http://t.co/m6oTWhQQuM via @MicrobiomDigest
8:55pm January 21st 2015 via Hootsuite
Interesting company: Creative Bioinformatics is like hiring a temporary bioinformatics postdoc. http://t.co/nScqK0Phcu
8:20pm January 21st 2015 via Hootsuite
Best Practices for Scientific Computing | PLOS Biology http://t.co/Pn30Fkh2nU HT @Jhagberg
7:50pm January 21st 2015 via Hootsuite
RT @lexnederbragt: #einframps2015 tweets have been storified! http://t.co/5z5mzEBgyO Thanks @SahaSurya
6:20pm January 21st 2015 via Hootsuite
Vela Dx Launches CE-marked Sentosa SQ Colorectal Cancer NGS Panel | GenomeWeb http://t.co/tNtf1Z5gEJ
5:05pm January 21st 2015 via Hootsuite
RT @mims: "Holograms can become part of our everyday life" says designer of Microsoft's new goggles http://t.co/RGlICB70cd
4:50pm January 21st 2015 via Hootsuite
SickKids Researchers Publish Pre-PCR Method for SNPs in GC-rich Regions | GenomeWeb http://t.co/EK5S3ujz2D @iontorrent
3:10pm January 21st 2015 via Hootsuite
Good for any age. 9 Things You Should Have Done By The Time You're 50 | Huffington Post http://t.co/IiV2L9cDgM
2:10pm January 21st 2015 via Hootsuite
RT @jonotter: How much is contamination affecting microbiome experiments? Probably more than you'd expect http://t.co/q8TziM3aQf
1:25pm January 21st 2015 via Hootsuite
How Technology will Eat Medicine - HealthKit, Theranos + cloud genomics | YourStory http://t.co/96t5JBBEY8 HT @rvaughnmd
12:15pm January 21st 2015 via Hootsuite
MT @GeneticsSociety: Our #DNADay essay contest is now open! http://t.co/jPm2AxRi6b The 2015 topic: the evolving definition of a gene.
11:05am January 21st 2015 via Hootsuite
RT @genomenathan: Mootha: Mito. made of ~1100 proteins (see MitoCarta). Mix varies greatly among organisms even tissues. #5points #nygc
10:35am January 21st 2015 via Hootsuite
RT @genomenathan: Mootha: mitochondria figure centrally in so many symptomatically diverse diseases. #nygc #5points
10:30am January 21st 2015 via Hootsuite
Bianchi:Q:Twins? A:Not 2x the fetal DNA; the woman caps the amt. of foreign DNA in blood. 1.4x - false negative cases higher ~10% #NICHD
10:07am January 21st 2015 via Hootsuite
Bianchi:Q:Role of oxidative stress? A:All part of accell. aging; why unknown, a # of disregulated pathways #NICHD
10:03am January 21st 2015 via Hootsuite
Bianchi:Q:congenital heart defects in mouse model? A:Yes they see it, emph. is on brain dev. They see lot of heart VSD's #NICHD
10:02am January 21st 2015 via Hootsuite
Bianchi:Promising results w/Apigenin - if in-utero treatment could work for T21, it may work for other aneuplodies #NICHD
10:01am January 21st 2015 via Hootsuite
Bianchi:Much discussion around NIPT maternal incidental findings; she may have cancer, DiGeorge Syndrome; sex chr. abnormality #NICHD
9:58am January 21st 2015 via Hootsuite
Bianchi:Will use 3D CT scans to monitor in-utero mouse brain development, also track neural stem-cell migration. #NICHD
9:54am January 21st 2015 via Hootsuite
Bianchi:Mice turning over; apigenin treatment orally; clear difference w/Ts1Cje after treatment on one test. Many other tests to do #NICHD
9:53am January 21st 2015 via Hootsuite
Bianchi:Describes a 'Comet Assay' showing halos in T21 model cells. Describes Ts1Cje mouse model for T21. Videos of mouse phenotypes #NICHD
9:50am January 21st 2015 via Hootsuite
Bianchi:Apigenin top candidate, naturally found (fruits & veggies), in-vitro assay described. Fluorescent assay for oxidative stress #NI
9:47am January 21st 2015 via Hootsuite
Bianchi:Eg safety, cross placenta, clinical improvement. What mouse model to use etc. Work is in process. First compound is Apigenin #NICHD
9:46am January 21st 2015 via Hootsuite
Bianchi:Hypothesis: treatment of ox. stress in-utero; use Connectivity Map to ID safe compounds to use in-utero. Many needs listed. #NICHD
9:45am January 21st 2015 via Hootsuite
Bianchi:Learning and memory - clin. trials ongoing to improve; but nerve cells and neural stem cells decrease w/time as T21 children #NICHD
9:43am January 21st 2015 via Hootsuite
Bianchi:40% of US women choose to continue preg w/T21; % stable; potential ~28 window to influence brain development #NICHD
Bianchi:Turners: a fetal autoimmune disease; cholesterol homeostasis; perivascular problems #NICHD
9:42am January 21st 2015 via Hootsuite
Bianchi:T21, T18, Turners: all have unique gene expression signatures. T18: NOTCH signaling; adrenal dev; T-cell med. immunity #NICHD
9:41am January 21st 2015 via Hootsuite
Bianchi: Oxidative stress in T21 fetus described here http://t.co/653OaT16Hj #NICHD
9:40am January 21st 2015 via Hootsuite
Bianchi: 2104 ref that describes DFLAT: http://t.co/ws1pDuDvRB Now desc. oxidative stress in T21 fetus: mitochondrial disfunction #NICHD
9:39am January 21st 2015 via Hootsuite
Bianchi: In T21 311 genes were diff exp; 1/3 down-regulated. Credits @NIH and #NICHD for support of a new tool DFLAT http://t.co/9R7HS5LFmH
9:37am January 21st 2015 via Hootsuite
Bianchi:In T21: consistent pattern. '09 PNAS: http://t.co/DPAgYzYiIk Genes were not on Chr21 - it is from genome disregulation #NICHD
9:36am January 21st 2015 via Hootsuite
Bianchi:Connectivity map from @broadinstitute dev for cancer; desc in 07 paper: http://t.co/WU3jjMWwSE #NICHD
9:35am January 21st 2015 via Hootsuite
Bianchi:Most fetal gene exp. is done post-mortem. Here: first time in living fetus from AF. Comparing transcriptomes across T21, T18 #NICHD
9:33am January 21st 2015 via Hootsuite
Bianchi:Char 23 organ-specific genes in AF core transcriptome. Possibly: during open neural tube formation. Majority from brain #NICHD
9:32am January 21st 2015 via Hootsuite
Bianchi:From GNF Novartis Gene Exp Atlas: showed GAPDH consistency across tissues; lung-spec gene SFTB signal in lung & fetal lung #NICH
Bianchi:Retrospective study from 6: Hui et al http://t.co/RIcYCcTjpB Used @ingenuity pathway analysis, @affymetrix U133A arrays #NICHD
9:31am January 21st 2015 via Hootsuite
Bianchi:cfRNA & cfDNA, of normal/ab AF, 2014 pub http://t.co/6cl0Xn6Lq4 why microarray? Connectivity map usefulness #NICHD
9:29am January 21st 2015 via Hootsuite
Bianchi:Rec. drugs for a mouse model and then (hopefully) bring it back to the pt. Amniotic fluid: pure source of fetal nucl. acid #NICHD
9:28am January 21st 2015 via Hootsuite
Bianchi:The next frontier: fetal individualized medicine. Fetal gene exp. via microarray, use connectivity map to rec. drugs #NICHD
9:26am January 21st 2015 via Hootsuite
Bianchi: NIPT now: for high-risk, clin. trials, prof. society guidelines, insurance paid. PPV is lower for low-risk pregnancies #NICHD
9:25am January 21st 2015 via Hootsuite
Bianchi:FP/FN in Boston Globe article Dec 14 http://t.co/glDa3azTcu It's a screen, not a test. FP about 0.1% #NICHD
9:24am January 21st 2015 via Hootsuite
Bianchi:Changes their counseling - a broader spectrum sex aneuploidy. Y-chr. in fetal (from kidney transplant!). Now maternal cancer #NICHD
9:23am January 21st 2015 via Hootsuite
Bianchi: Her analysis reported in Clin Chem http://t.co/crrNM3Jn8m FP for sex char: mother's sex-chr. mosaicism 9% of the time #NICHD
9:22am January 21st 2015 via Hootsuite
Bianchi:Impact: dramatic. Rev of billing records show this, 2014 publ. http://t.co/hC9kVbwstW #NICHD
9:20am January 21st 2015 via Hootsuite
Bianchi:When NIPT is neg. - so close to 100%, no invasive testing. If pos. - need confirmatory testing. Low-risk: offered at Tufts #NICHD
9:19am January 21st 2015 via Hootsuite
Bianchi:In '11:T21, T18, T13: meta-analysis here, Gil et al http://t.co/l0FnMYsLds Very high accuracy detailed there #NICHD
9:18am January 21st 2015 via Hootsuite
Bianchi:cfDNA in maternal plasma comes from placenta, not the fetus; detectable in anembryonic gestations, before circ. established #NICHD
9:16am January 21st 2015 via Hootsuite
Bianchi:Showed inflection of NGS in '08; revolutionary concept of use as a tag-counting device. Reviewed cfDNA sequencing/mapping #NICHD
9:14am January 21st 2015 via Hootsuite
Bianchi:NIFTY should have been TM'd; now done by BGI (China) 4K samples to-date. Issue: how industry 'has run w/the ball' #NICHD
9:13am January 21st 2015 via Hootsuite
