RT @AbandonedPics: Abandoned library outside of Moscow, Russia http://t.co/DWEGfJZQKR
9:20am April 10th 2014 via Hootsuite in reply to
RT @noahWG: Proportion of non-tenure-track & non-tenured faculty posts still rising across all US institutions: http://t.co/ExFfNlSwOE
8:20am April 10th 2014 via Hootsuite in reply to
Genomics and PGx mentioned RT @rovybranon: Why The Digital Revolution Is Really Just Getting Started - Forbes http://t.co/0yEj4dloLi
RT @mohamedghilan: The undergraduate science class is designed in a way that gives a false impression for how certain science actually is.
7:20am April 10th 2014 via Hootsuite in reply to
A ‘challenger mindset’ RT @RWW: Microsoft’s @SatyaNadella: We Still Do Windows, And You Should Too http://t.co/uvF1JIJ8w1 by @owenthomas
6:20am April 10th 2014 via Hootsuite in reply to
RT @mjpchaisson: If it weren’t for the price hikes, @illumina’s monopoly would be a good thing at least for standardization.
5:20am April 10th 2014 via Hootsuite in reply to
RT @nathanseligson: Direct-to-Confusion Genomics: who will decipher the data? http://t.co/IpeCAE0zpe | Daily Scan #PersonalizedMedicine
4:20am April 10th 2014 via Hootsuite in reply to
The ave. rent in Silicon Valley now $2881. WSJ http://t.co/BfikTXTMWX
3:20am April 10th 2014 via Hootsuite
RT @macworld: AirPlay Recorder might exist in a bit of a gray area, but it's a solid tool that works as promised. http://t.co/Hw8xenHceh
2:20am April 10th 2014 via Hootsuite
RT @NatureNews: Bees in peril in the EU: "If we don’t get it right now, that’s it.” http://t.co/UvAOXYJEVo http://t.co/K3bRKjZWuQ bb
1:20am April 10th 2014 via Hootsuite
RT @NatureMagazine: The Moon-forming impact with Earth must have occurred at least 40My after Solar System formed http://t.co/ShD6wpiA6M
12:20am April 10th 2014 via Hootsuite
RT @NCIExhibits: View available webcasts of NCI presenters at #AACR14 by visiting http://t.co/tpIZ4IyNk8.
11:20pm April 9th 2014 via Hootsuite
RT @mathheadinc: Want people to think you’re smarter? Smile more | Washington Post http://t.co/Y7I8AvAwyl #statchat #mathchat
10:20pm April 9th 2014 via Hootsuite
RT @TheEconomist: Scientists have persuaded an organ to regenerate itself inside a living mammal http://t.co/FDnygFOxuC
9:20pm April 9th 2014 via Hootsuite
RT @Harvard: Watch the world's first programmable, mechanical computer come to life [video] http://t.co/6jK9Zmjngy
8:20pm April 9th 2014 via Hootsuite
RT @AppliedBio: Download PDFs of all our posters from #AACR14 right here: http://t.co/gqkVWGlSCb
7:20pm April 9th 2014 via Hootsuite
10 common presentation mistakes | Mind Tools http://t.co/fw20yKGMsP
6:20pm April 9th 2014 via Hootsuite
RT @HealthStandards: Fourth HIPAA breach for Kaiser was due to malicious software >> http://t.co/eIEJC3Kuy4 via @HITNewsTweet #HITsm
5:20pm April 9th 2014 via Hootsuite
RT @FastCoLead: Do you already have any of these 7 habits of the highly emotionally intelligent? http://t.co/GCQqeLTzSv
4:20pm April 9th 2014 via Hootsuite
Many thanks to all the folks who have participated over Twitter at this year’s #AACR14 - great meeting!
1:03pm April 9th 2014 via Hootsuite
Next: Luis Parada, UT Southwestern Med Ctr. "Where Lies the Heterogeneity in GBM" #AACR14
12:37pm April 9th 2014 via Hootsuite
Ley: Here's the 1979 Testa and Rowley paper with which he started his talk http://t.co/E4gMrxraLN #AACR14
Ley: 'It's not enough to know the mutations - it's the clones in which they reside' #AACR14
12:36pm April 9th 2014 via Hootsuite
Ley: Concluding model - pre-leukemic event. Another hit (cooperating driver mut) making founding clone. 2D with VAF req'd deep seq #AACR14
12:35pm April 9th 2014 via Hootsuite
Ley: Can expand primary AML in vitro; but after expansion SC3 has growth advantage. A cell-intrinsic growth advantage #AACR14
12:29pm April 9th 2014 via Hootsuite
Ley: Charting driver VAFs in BM vs Blood, very similar, pattern holds across 19 samples. Conclude for adult AML periph blood equiv #AACR14
12:27pm April 9th 2014 via Hootsuite
Ley: Recent pub work Klco et al Cancer Cell 2014 http://t.co/do7fpFAzMs most subclones present in ~proportions in marrow, blood #AACR14
12:26pm April 9th 2014 via Hootsuite
Ley: Therapy eliminated subclone (SC) 1, SC2, but SC3 and founders. #AACR14
12:24pm April 9th 2014 via Hootsuite
Ley: Map of tumor VAF and specific mutations (FLT3-ITD, FLT3, IDH1, NPMc, DMNT3A). But 3D - what happens in relapse? #AACR14
Ley: At 300x: 1411 muts validated. Many many more: even 100x exomes still missing a lot: basics but details missing #AACR14
12:21pm April 9th 2014 via Hootsuite
Ley: Looking at 4 different clonal heterogeneity; WGS at 30x depth isn't deep enough. What about 300x? Presenting AML31 work #AACR14
12:20pm April 9th 2014 via Hootsuite
Ley: He showed a figure from this 2012 Nature paper http://t.co/mf0z7cYcqf to J Rowley. "Gosh, you really improved the graphics" #AACR14
12:18pm April 9th 2014 via Hootsuite
Ley: Analyses: 1D = mutations; 2D = muts, clonal hetergeneity (Campbell); 3D clonal evolution #AACR14
12:17pm April 9th 2014 via Hootsuite
Visvader: 4w post-induction of neu in early luminal precursors, nice 3D images illustrate cell of origin effect #AACR14
11:58am April 9th 2014 via Hootsuite
Visvader: Elf5/mic high grade adenocarcinoma at 4mo; Ky/myc no tumors at 22mo. Tumor type det by 'cell of origin. #AACR14
11:57am April 9th 2014 via Hootsuite
Visvader: Using similar approach (K5/Elf5, basal- and luminal-spec): look at oncogene myc involvement #AACR14
11:56am April 9th 2014 via Hootsuite
Visvader: 'Cells of origin': can enable early detection, better prediction of tumor behavior, could lead to new therapies #AACR14
11:55am April 9th 2014 via Hootsuite
Visvader: Intertumoral hetergeneity (part 2 of talk): genetic mut model and cell of origin are not mutually exclusive #AACR14
Visvader: MaSCs long-lived - could they be prime targets for mutations as br ca progenitors years later? #AACR14
11:54am April 9th 2014 via Hootsuite
Visvader: Lgr5 another mark in alveolar gland - marks bipotent MaSCs. #AACR14
11:53am April 9th 2014 via Hootsuite
Visvader: Now looking at alveolar cells during pregnancy - K5-expressing bi-potent cells active #AACR14
11:52am April 9th 2014 via Hootsuite
Visvader:Even after 52w - mammary gland actively maintained much longer than anticipated. 'Shows the stem cell is long-lived' #AACR14
11:51am April 9th 2014 via Hootsuite
Visvader: FACS: K5 cells are both luminal and basal lineages; both populations expanded. 20w: stem cells maintained duct & tree #AACR14
Visvader: Tet-inducible Keratin5 - basal cell expression; visual of stem cells giving rise to progeny at puberty. 8w - segregation #AACR14
11:48am April 9th 2014 via Hootsuite
Visvader: Colorful data: Elf5-expressing cells contribute to ductal maintenance in adulthood; but by 20w depleted #AACR14
11:47am April 9th 2014 via Hootsuite
Visvader: Efl5 TF: signature of luminal progenitor cells and GFP; only Elf5-GFP have clonogenic activity in vitro #AACR14
11:45am April 9th 2014 via Hootsuite
Visvader: Used 3 color trangenic mice, Dox-inducible: indelible marking of cells and progeny throughout lifespan #AACR14
11:44am April 9th 2014 via Hootsuite
Visvader: Recent work reported Rios et al Nature 2014 http://t.co/yGSg0jy7tO looking at lineage tracing, triple transgen. mice #AACR14
11:43am April 9th 2014 via Hootsuite
Visvader: 3D imaging of mammary gland of keratin fiber prior to puberty: 3D movie, highly elongated #AACR14
11:42am April 9th 2014 via Hootsuite
Visvader: Looking at mammary stem cells - an evolving heirarchy from stem cells, to progenitor cells, to mature cells. ER-PR- #AACR14
11:40am April 9th 2014 via Hootsuite
