Friend: Q:Will there be tiers of researchers? (say genomics experts + housewives?) A: Absolutely not. Treat others as equals #AACR14
10:49am April 6th 2014 via Hootsuite
Friend: A shift in how we train - assume the rest of the world is ready and willing to work with the problems we have #AACR14
10:45am April 6th 2014 via Hootsuite
Friend: Lists a large set of new skills needed at the graduate level - data analytics, collaboration tools, generous with ideas... #AACR14
10:44am April 6th 2014 via Hootsuite
Friend: Data mined AACR13 abstracts and looked at relationships between topics and authors. Mon session: http://t.co/JBH7AGCWv8 #AACR14
10:43am April 6th 2014 via Hootsuite
Friend: At a meetings like #AACR - why can't we know who is doing what? Guinney / Dienstmann build a 'scientific interactome' in 2013
10:40am April 6th 2014 via Hootsuite
Friend: Existing companies just interact indiv's, research needs a much broader base for this kind of work #AACR14
10:39am April 6th 2014 via Hootsuite
Friend: Parkinson's Voice Initiative http://t.co/hEVK9mLel7 saying an 'ah' word, building voice data from the public #AACR14
10:38am April 6th 2014 via Hootsuite
Friend: Health data tracking - sometimes as a product (23andMe listed), but proposes a project called 'Bridge' #AACR14
10:36am April 6th 2014 via Hootsuite
Friend: Upcoming histopathology challenge needs to go farther - to get citizen involvement. Phenotypic data to match genotypic data #AACR14
10:35am April 6th 2014 via Hootsuite
Friend: For br cancer - DREAM has forums, leaderboards. 'If you want people to share, allow them to compete'. http://t.co/Euit2UQZu0 #AACR14
10:32am April 6th 2014 via Hootsuite
Friend: Pointed to this paper: http://t.co/AcUs53g2SQ and stated that it will in 10y become very prominent. 'Indiv systems medicine' #AACR14
10:28am April 6th 2014 via Hootsuite
Friend: Synapse enabled large-scale collaboration. 3 genome modifications x 3 systems x multiple analyses #AACR14
10:27am April 6th 2014 via Hootsuite
Friend: Project using #TCGA and Synapse (project) - publ. in a very short time. Onberg et al Nat Genet Pubmed http://t.co/vihWLkuUDd #AACR
10:25am April 6th 2014 via Hootsuite
Friend: 'Open social media allows citizens and experts to use gaming to solve problems'. SolveIt, Eterna - a housewife helping out #AACR
10:23am April 6th 2014 via Hootsuite
Friend: A generational, open approach for data-driven analysis. 'What if we could learn from everyone, everywhere?' #AACR
Meet Expert: S Friend, Sage Bionetworks "NextGen Cancer Res: Why the Existing Siloed, Guild-Like System Will Soon Be Less Relevant" #AACR14
10:21am April 6th 2014 via Hootsuite
3D printer price drops could lure home users - PC World http://t.co/qiVvektvNS
7:20am April 6th 2014 via Hootsuite
RT @PopSci: This is how you science: Geneticists create 3,500 fly strains to find one that moonwalks http://t.co/x5ctXhZCgy
6:20am April 6th 2014 via Hootsuite in reply to
Solid public-speaking advice RT @ValaAfshar: How to give a great speech | Forbes http://t.co/1XT7ib8a7M
5:20am April 6th 2014 via Hootsuite
Ivan Misner: Work-Life Balance Is a Sham| http://t.co/DuboEZ3NQY http://t.co/INlUne3ACp
4:20am April 6th 2014 via Hootsuite
RT @conradhackett: Who likes Americans? S Korea 80% Uganda 73 Japan 73 Canada 71 France 67 Russia 60 Mexico 59 China 39 Egypt 32 Trky 20
3:20am April 6th 2014 via Hootsuite
Using Hi-C NGS RT @thinkgenome: Scientists generate 3-D structure for the malaria parasite genome | MedXpress http://t.co/kwD5LKb2wB
2:20am April 6th 2014 via Hootsuite
RT @jordosh: Do you know an exceptional teacher? Nominate them for the $1 million Global #TeacherPrize http://t.co/WA2LXV3NAk
1:20am April 6th 2014 via Hootsuite
RT @AgilentGenomics: Our wildly popular NGS 101 series is now avail on-demand #RNA-Seq #Methyl-Seq, Data Analysis... http://t.co/WvmZB2pySJ
12:20am April 6th 2014 via Hootsuite
RT @MayoClinicCIM: Psychiatric #Genetics Hold Great Promise | Psychiatry Online http://t.co/qpvIhp8UxR
11:20pm April 5th 2014 via Hootsuite
RT @conradhackett: GOOD NEWS: US violent crime rate falling - the overall 2012 rate was the lowest in over 40 years. http://t.co/Wzk6a7EPIz
10:20pm April 5th 2014 via Hootsuite
Botstein: Conclude similarities - population evolution with a fitness advantage. The # of paths to increase fitness limited #AACR14
9:21pm April 5th 2014 via Hootsuite
Botstein: Metabolism - limit leucine, burn through glucose. Same with limited phosphate, uracil. Reminiscent of tumor cells #AACR14
9:19pm April 5th 2014 via Hootsuite
Botstein: Looked at a mating pathway with a reporter, 1K generations, Lang 2009 PubMed: http://t.co/fl4K90q0Qz #AACR14
9:10pm April 5th 2014 via Hootsuite
Botstein: 8 indep evolved strains have copy-number variation via aCGH; analysis showed similarities to BCR-ABL. #AACR14
8:56pm April 5th 2014 via Hootsuite
Botstein: References 1999 paper on up/down regulation of genes in yeast under glucose limitation PubMed http://t.co/Ari1cynWvH #AACR14
8:53pm April 5th 2014 via Hootsuite
Botstein: (Courtesy @deannachurch - 2012 talk at the NIH http://t.co/8IKXdsS8Ui ) #AACR14
8:51pm April 5th 2014 via Hootsuite
Botstein: Photo of Monod and Szilad; invented the Chemostat, enabling single-cell organism growth in a steady-state equilibrium #AACR14
8:48pm April 5th 2014 via Hootsuite
Botstein: A 'galaxy' of genes grouped by function; we understand about 2/3rds of the yeast genes #AACR14
8:46pm April 5th 2014 via Hootsuite
Botstein: Uses figure from this Constanzo 2010 Science article PubMed: http://t.co/etkPP1ACTb Functional relationships between yeast #AACR14
8:44pm April 5th 2014 via Hootsuite
Botstein: There is a broad consensus that cancer is somatic gain of special properties, and then just natural selection. #AACR14
8:41pm April 5th 2014 via Hootsuite
Botstein: "Evolution is anymore no longer a theory as gravity is." Theoretical and practical reality. #AACR14
8:40pm April 5th 2014 via Hootsuite
Botstein: "It was natural to apply microarray technology to cancer" "Unless you have a primary text, there's nothing to translate" #AACR14
8:38pm April 5th 2014 via Hootsuite
Botstein: 'I don't think of myself (nor any of you thought of me) as a cancer biologist' #AACR14
8:36pm April 5th 2014 via Hootsuite
Tenth Annual AACR-Irving Weinstein Foundation Distinguished Lecture: David Botstein, Princeton Univ "Evolution and Cancer" #AACR14
8:35pm April 5th 2014 via Hootsuite
Solyom: 28/58 in pre-cancerous colon polyps, 13/24 in IBD dysplasias, not found in healthy tissue #AACR14
7:58pm April 5th 2014 via Hootsuite
Solyom: Validated via PCR in somatic L1 insertions in colon ca. Insertions were in many important genes (COSMIC) #AACR14
7:56pm April 5th 2014 via Hootsuite
Solyom: L1-Seq - looking at human-specific L1's via assymetric then hemi-specific PCR PubMed http://t.co/dgPn2I5QT2 #AACR14
7:48pm April 5th 2014 via Hootsuite
Solyom: Has unique gastrointestinal cancer cancer samples from L1 retroposon insertions. Also IBD, pancreatic cancers #AACR14
7:46pm April 5th 2014 via Hootsuite
Solyom: >100 diseases caused by retroelement insertions in humans. 25 L1, 61 Alu, 10 SVA... #AACR14
7:43pm April 5th 2014 via Hootsuite
Solyom: Laid out L1 method of transposition Beck Ann Rev Genetics PubMed: http://t.co/lurpKGWW4V #AACR14
7:42pm April 5th 2014 via Hootsuite
Solyom: Concentrating on L1: 6kb, 2 ORF's, 5' and 3' UTR's, 500K copies in human genome. Binds to same RNA that encode it #AACR14
7:40pm April 5th 2014 via Hootsuite
Solyom: Types of mobile elements: L1, Alu, SVA, HERV, DNA transposons. Copy numbers from 2.7K (SVA) to 1M (Alu). #AACR14
7:39pm April 5th 2014 via Hootsuite
Next up: Szilvia Solyom, Johns Hopkins "A potential role of retrotransposons in cancer" #AACR14
7:37pm April 5th 2014 via Hootsuite
Rosenfeld: Pit1 R27W mutation - no catenin binds, combined pituitary hormone deficiency, may become a target #AACR14
7:35pm April 5th 2014 via Hootsuite
