Malkin #AACR23 One of three context: Neurofibromatosis Type 1 (NF 1), 1:3500 freq single-gene disorder. Tumor dev,… https://t.co/RpvIsh4zhD
7:07am April 17th 2023 via Twitter Web App
Malkin #AACR23 Most findinds are new information; 78%, 22% previously known. Medulloblastoma - clinical outcome ass… https://t.co/FXbc5fYRNl
7:05am April 17th 2023 via Twitter Web App
Malkin #AACR23 Pediatric world is ahead of the adult oncology one: germline variants are common. Nature Cancer 2022… https://t.co/fGm4ZOzSaW
7:04am April 17th 2023 via Twitter Web App
Good morning! David Malkin (Univ Toronto CAN) #AACR23 Prediction and prevention: seeking the holy grail for cancer… https://t.co/IOJ9kQmIFh
7:02am April 17th 2023 via Twitter Web App
June #AACR23 CD2 CAR-T cell therapy have acceptable toxicity and efficacy in pediatric solid tumors.… https://t.co/kr3ZCZewNm
5:08pm April 16th 2023 via Twitter Web App
June #AACR23 With Human T-cells, many genes to knock out - shows a list of 30 genes, to address many issues in soli… https://t.co/NqFP6qodzs
5:06pm April 16th 2023 via Twitter Web App
June #AACR23 Epitope editing does not result in loss of CD45 expression, and has more potent anti-tumor activity th… https://t.co/IzIVQ0gTCE
5:02pm April 16th 2023 via Twitter Web App
June #AACR23 Alanine mutagenesis scan to ID a.a.'s req'd for scFv CD45 epitope. Ab called 9.4 has D229-Y232 deleted… https://t.co/UEkYvhAs6j
4:56pm April 16th 2023 via Twitter Web App
June #AACR23 Sequential truncation via CRISPR identifies domain targeted by anti-CD45 '21 Curr Opin https://t.co/zPb497WyzO
4:55pm April 16th 2023 via Twitter Web App
Carl June #AACR23 AACR Award for Lifetime Achievement in Cancer Research. Second half: Drugging the 'undruggable' C… https://t.co/pE3dXSHZFt
4:54pm April 16th 2023 via Twitter Web App
Jenkins #AACR23 Q: How do you know what cell-types are secreting which proteins? A: Inferred - IL-8 and looking at… https://t.co/h34a2UB1Hv
4:21pm April 16th 2023 via Twitter Web App
Jenkins #AACR23 Spotlight C Acknowledges Arnahve Mehta, Genevieve Boland, also members of the Olink team.
4:15pm April 16th 2023 via Twitter Web App
Jenkins #AACR23 Spotlight C, looking at ex-vivo responses. scRNA sequencing, looking at features that correlate wit… https://t.co/T6Xfc5nt5G
4:14pm April 16th 2023 via Twitter Web App
Jenkins #AACR23 Spotlight C Olink presentation: Immune checkpoint blockade increases TNFa / IFNg. Also studying pat… https://t.co/qz9Z2d0L5E
4:12pm April 16th 2023 via Twitter Web App
Jenkins #AACR23 Spotlight C: Now onto gastric cancer; this time w/chemotherapy followed by I-O. https://t.co/V5iJxfKa0K
4:10pm April 16th 2023 via Twitter Web App
Jenkins: #AACR23 Spotlight C @OlinkProteomics presentation - looking at the contribution of tumor immune cells on t… https://t.co/NldpyOyWr3
4:04pm April 16th 2023 via Twitter Web App
Dive #AACR23 CRUK is recruiting a new director - she invites an 'superstars to reach out'.
2:14pm April 16th 2023 via Twitter Web App
Dive #AACR23 Looking at IHC for COX-2, shows data in tissues from LUSC and LUAD (poster) Also - risk of relapse of… https://t.co/qmS7bf7Wrz
Dive #AACR23 Finding lots of Stg I lung cancers - now access to large numbers of tissues. Oppy to examine early immune landscapes.
2:10pm April 16th 2023 via Twitter Web App
Dive #AACR23 It may be a 'watch this space' talk - lung cancer at scale, community based, multi-analyte, radiomics… https://t.co/JFhFwtKQDa
2:08pm April 16th 2023 via Twitter Web App
Dive #AACR23 Plan to apply also T7-MBD-Seq assay that does not use bi-sulfite treatment, from Rothwell group at CRU… https://t.co/E9eT8olBRu
2:07pm April 16th 2023 via Twitter Web App
Dive #AACR23 Lung Cancer Likelihood in Plasma (Lung-Clip) the 'gold standard' from Stanford's Max Diehn. 2020 ref: https://t.co/ZWWevLewFz
2:06pm April 16th 2023 via Twitter Web App
Dive #AACR23 Pilot cohort - from Stg I lung ca's, and counted rare cells (n=42) early data can see the difference in signal.
2:04pm April 16th 2023 via Twitter Web App
Dive #AACR23 Try to combine - 1, 2 or 3 analytes. May be able to reduce number of scans. Adapting a High Def Singl… https://t.co/iGE8ktnJBF
2:03pm April 16th 2023 via Twitter Web App
Dive #AACR23 MCED's are still low sensitivity for Stg 1 lung cancer. So go for ctDNA for tumor cell death; and CTCs… https://t.co/imdJCHkPWJ
2:01pm April 16th 2023 via Twitter Web App
Dive #AACR23 A 15' low dose CT, oppy to get blood samples at the same time. Scan positive - second blood sample. 80… https://t.co/lYbio5tmYW
2:00pm April 16th 2023 via Twitter Web App
Dive #AACR23 2 Q's - circulating rare cells ID asymptomatic patients? Or a combination of ctDNA plus CTCs? A mobile… https://t.co/lRU9YOjfWP
1:58pm April 16th 2023 via Twitter Web App
Dive #AACR23 Stage shift ongoing: low-dose CT-screening for lung cancer early detection. Shows how 50% LDCT are fal… https://t.co/Pkh9JbQYtB
1:57pm April 16th 2023 via Twitter Web App
Caroline Dive (Cancer Research UK, Manchester UK) Development of a multimodal liquid biopsy to augment low dose-CT… https://t.co/1skff4uH0L
1:56pm April 16th 2023 via Twitter Web App
RT @Aiims1742: Dr. Deb Schrag @MSKCancerCenter delivered an outstanding #AACR23 plenary talk lending a cautionary note to the challenges of…
1:52pm April 16th 2023 via Twitter Web App
Baslan #AACR23 This instability - falls within chaos theory in math. Tolerance to uncertainty, accuracy of measurem… https://t.co/9mgC5WhuUc
1:28pm April 16th 2023 via Twitter Web App
Timour Baslan (Memorial Sloan Kettering CC NY) #AACR23 Ordered and selective patterns of cancer genome evolution re… https://t.co/iohZn0PIkL
1:27pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 Lots of acknowledgements, lots of funds, and a large team.
1:23pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 Ends with a patient with Xeroderma pigmentosum, in his 30's, had Stage IV metastatic disease, ho… https://t.co/RlOoZodXfK
Nik-Zainal #AACR23 Shows examples from ovarian cancer, BRCA mutation, HRDetect scores, patterns. ER+ve breast cance… https://t.co/g53yX8gMQa
1:21pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 4% mis-match repair deficient, have other abnormalities that could be pursued with HRDetect. Cha… https://t.co/i5L5fyybqk
1:18pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 Targeted misses 1/3 of tumors with BRCAness; driver isn't ID'd, caused by structural var, caused… https://t.co/8ewiF3Q9eE
1:17pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 Did PARPi, found correlation following Rx 2020 Nature Comms https://t.co/HbCD9G1ZUY
1:16pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 A third of the cohort - can see the signatures in breast cancer, but unknown etiology. Paired wi… https://t.co/mKa6Vjqrl4
1:15pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 Started 2020, now up to 17K. Have to demonstrate prognostic / predictive value. Genomics England… https://t.co/oAOaLrptfG
1:14pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 Champions WGS due to it's one-shot nature. Exposure to Aristolochic Acid, Sig 22; a different on… https://t.co/iRxCTt73Ea
1:12pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 Then validated in indep cohorts (Hartwig and ICGC). Showed previously ID'd and 58 new signatures… https://t.co/y1WQKy3XOh
1:10pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 12K from genomics England, add'l IGCG 3K, Hartwig 3.4K; total of 18K 2022 Science… https://t.co/6vhO4KuQzL
1:09pm April 16th 2023 via Twitter Web App
Nik-Zainal #AACR23 Signatures - deamination of methyl-cytosine, deamination of APOBECs. Additional signatures - 201… https://t.co/oQUUkbHDsu
1:06pm April 16th 2023 via Twitter Web App
New insights into cancer initiation, evolution, therapy, and survivorship through Big Data analysis #AACR23 Serena… https://t.co/FHSrMfbBgH
1:02pm April 16th 2023 via Twitter Web App
Zimmers #AACR23 Concludes - cachexia is generally untreated; cancer drives it through specific, targetable therapie… https://t.co/wH74aDIT6R
11:02am April 16th 2023 via Twitter Web App
Zimmers #AACR23 Blocking muscle wasting impede pancreatic tumor growth. Preprint in Nature https://t.co/jdAsrNsXRI
10:59am April 16th 2023 via Twitter Web App
Zimmers #AACR23 IL-6 mediates feed forward inflammaiton, cachexia, and tumor progression in the macroenvironment. A… https://t.co/EkD5HOehLg
10:56am April 16th 2023 via Twitter Web App
Zimmers #AACR23 On to GDF-15, opportunity and in Ph I clinical trials for cachexia. https://t.co/FFltkXONnE
10:55am April 16th 2023 via Twitter Web App
Zimmers #AACR23 Shows prolonged survival in mice. Cachexia is sexually dimorphic; only males respond to activin inh… https://t.co/g81JrA0YOv
10:53am April 16th 2023 via Twitter Web App
