Tweets from web

#ampeurope2018 William Dalton (Moffitt Cancer Center Tampa FL USA) Oncology Research Information Exchange Network (ORIEN)

9:56am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: CYP450 variation, now crowdsourced CYP2D6, 2D9, and other var's entered into https://t.co/qclgTn45rz

9:51am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: To contribute as subject matter experts (SMEs), boundary checking, thoughtful defaults

9:50am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: What to do: implementation science. Data science teams 'have to be interdisciplinary'. SEM and Technical expert.

9:49am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Few labs discuss release of 2nd-ary findings to family.

9:49am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: 18 academic consnet forms, and worked through consent. https://t.co/0e8KsKkVVL Complexity was 10.8 and rec'm was 8

9:48am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Maintaining curation harder and harder. Fixed codes w/sequencing, cytogenetics: something unanticipated.

9:47am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Clinical Bioinformatics Ontology: '05 https://t.co/HDE0VAGa2m As the field has become more complex...

9:46am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Shows cahrt of HbA1c codes for different sickle-cell conditions in ICD-9 and ICD-10.

9:45am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: LOINC, SNOMED, ICD-10 are terminologies. Other option is to formalize a syntax. More often in MDx, say HGV

9:44am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: interoperability: NA, Sod, Sodium supposed to mean the same thing. E. coli O157:11 variant with a like concept

9:44am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Truman: 3x the rate of A1c test on SS-affected, room to improve by making a change in their system 'popup alert'

9:40am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Ethnic demo: conclude that Truman Medical (their site) admits less frequent 'biracial' intake code

9:39am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: 863 facilities, 734M medication orders, 489M diagnoses. ID'd 41K SS-affected (40% of the US-affected)

9:38am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: They have a CDC grant to use large data warehouses to improve quality. 63M pts, 4.3B lab results.

9:37am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: They have aggregate EHR data, De-ID, Map, normalize into 'Health Facts' from Cerner.

9:35am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Big Data with common genetic disease: sickle cell, HbA normal, HbSS 1/13 Af Americans carriers

9:34am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Most data must be manipulated before feeding algorithm; decisions need to be rigorously documented.

9:33am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: We imagin a well-oiled machine, but it's the wizard of Oz behind the curtain (GIFs shown!)

9:33am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Big data my have unk origin, out of context, inappropriate level of rigor, and hype.

9:32am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Espt with experimental methology nuances. Experts can't necessarily ID the correct result.

9:31am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Pediatric genomics at Childrens' Mercy: founded in '11, 7476 familys sequenced. 14TB ram and 58 node, 2200-cores.

9:30am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: PDF reports, filed away, and never looked at again. 36% 'continued in error'; 18% 'not aware of gt reports'

9:28am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: 6mos later, 42 given other antiviral also contraindicated. Saw higher viral load, lower CD4 cts

9:28am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: HIV genotype, matched with molecular and pt data. 441 w/resistant GT, 239 had contraindicated Rx !

9:27am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Pt outcomes: resp to Rx; operational: cost-effective. Ex: '07 https://t.co/FRbLlEGuKa

9:26am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Success req's data integration, integrate clinical data, molecular data, and financial data.

9:25am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: 20K genes, and 3B nucleotides x 2. Devices and EHR; and the individual (apps, search, tweets...) :)

9:25am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Data explosion: 10^10 neurons, 10^14 connections. 250K-1M unique protiens. 10T microbial cells/indiv

9:24am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Clinical trials progressing - but slowly. Data fed into supervised, unsupervised, and deep learning models

9:23am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: 23M citations in Medline, and major opps to improve quality of care, HAI, AEs, disparities

9:22am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Hoffman: Many goals and has elusive goals - predict and improve pt outcomes; improve utilty; demo cost-effectivenss

9:21am May 2nd 2018 via Twitter Web Client

Mark Hoffman (Children's Mercy Kansas City MO, USA) #ampeurope2018 Turning Little Data into Big Data: Data Science and the Omics

9:17am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Laura Tafe (Dartmouth NH) Emerging knowledge: clinically significant big data

9:17am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Ferreira-Gonzalez: You need trained individuals to interpret in the clinical context. And policies for consistency needed.

7:02am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Tyrelle: Battle5: 26 clinical trials, many pages of reporting (and available as demo at their stand)

6:53am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Tyrelle: Illustrates flow info and how its used: where FNs get special information. Flow-space numbers: fwd/rev strands

6:46am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Tyrelle: Torrent Variant Caller (TVC) have two flows: one w/o hotspots, another with. W/o: no calls may be there.

6:43am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Tyrelle: And Oncomine KB Reporter links variants to evidence. Reporter is free to use to a certain amt.

6:40am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Tyrelle: And larger chips have exome capability. Aligned BAM gets to variant calls. Annotate and Filter: using Ion reporter

6:39am May 2nd 2018 via Twitter Web Client

#ampeurope2018 Greg Tyrelle @gtyrelle Thermo Fisher: other competitors (5 others) declined to participate.

6:38am May 2nd 2018 via Twitter Web Client