RT @JEMgenes: I’ve been to ASHG several times, but #ASHG22 will not only stick out for the science but all the hugs and friendly faces i ha…
9:26am October 30th 2022 via Twitter Web App
Great tweet summery from #ASHG22 that lays out the power of the UKB Plasma Proteomics Project using… https://t.co/GVFGuwLPWP
8:28am October 28th 2022 via Twitter Web App
RT @VincentPlagnol: Two plenary talks into #ashg22 and two talks leveraging @uk_biobank. The impact of UKB on our understanding of human ge…
8:24am October 28th 2022 via Twitter Web App
Venner: #ASHG22 Pathogenic variant detection by ethnicity: highest in European. Shows pathogenic variants in PALB2… https://t.co/Xx26YmEbxq
5:26pm October 27th 2022 via Twitter Web App
Venner: #ASHG22 Comparison to GnomAD, broad high concordance across ethnicities. Some outliers are resolved by subs… https://t.co/Y3PpIrshaO
5:22pm October 27th 2022 via Twitter Web App
Eric Venner #ASHG22 Frequency of known pathogenic variants across ancestries in the All of Us Research Program coho… https://t.co/AnTGOtIFPz
5:20pm October 27th 2022 via Twitter Web App
Q: Can another method be used for this? A Lu: Used ILMN custom array, haven't gone beyond that. #ashg22
2:48pm October 27th 2022 via Twitter Web App
Lu: Shows data of CpGs with positive age correlation. BiorXiv preprint: https://t.co/Gs2O2s3GUh #ashg22
2:47pm October 27th 2022 via Twitter Web App
Lu: Pan-mammalian clocks predict human all-cause mortality risks. Applied to muring aging - lowered growth hormone… https://t.co/oHG8FbGqsB
2:41pm October 27th 2022 via Twitter Web App
Lu: n=11.7k DNA samples, 185 spp. Shows correlations of 0.95, then 0.98 of DNAm relative age to chron age. Shows da… https://t.co/1kLZUp47Bx
2:39pm October 27th 2022 via Twitter Web App
Lu: Main challenge is dev of mathematical model. Relative age per species. Non-linear - elastic net model. 3rd cloc… https://t.co/XaWqbRYxjl
2:37pm October 27th 2022 via Twitter Web App
Lu: 3rd-generation. 37K CpGs using a custom microarray. Shows chart of conserved sequences between human, chimp, al… https://t.co/nFy6SlprUd
2:35pm October 27th 2022 via Twitter Web App
Ake Tzu Hui Lu (Altos Labs / UCLA Ca) Universal DNA methylation age across mammalian tissues #ashg22 Mammalian Cons… https://t.co/HAaVRi0qlk
2:34pm October 27th 2022 via Twitter Web App
RT @ninadoak: Presidential Symposium on African Genomics led by #CharlesRotimi and Francis Collins along with amazing scientists working on…
2:29pm October 27th 2022 via Twitter Web App
RT @kerencarss: Feels like every other talk at #ASHG22 uses @uk_biobank data. Its hard to think of any other resource that compares to its…
2:28pm October 27th 2022 via Twitter Web App
Heseyin Gedik (VCU Va) ID potential causal genes by integrating molecular intermediate phenotypes and GWAS signals… https://t.co/D0SdELl5AQ
2:09pm October 27th 2022 via Twitter Web App
Q: Has Loopseq been applied to WGS? Yehezkel #ASHG22 Not for assembly, there are other (better) choices to get to 5… https://t.co/ABR84FnlER
11:03am October 27th 2022 via Twitter Web App
Q: Any palindromes or other sequences that Loopseq has trouble with? A: Yehezkel #ASGH22 Microsatellites come to mi… https://t.co/GqZp3FiKuo
11:00am October 27th 2022 via Twitter Web App
Yehezkel: Limitation of Loopseq is the limitation of long-range PCR, thus 5Kb to 7Kb lengths. Concludes with unpubl… https://t.co/FksEEzt09x
10:54am October 27th 2022 via Twitter Web App
Yehezkel: Comparison between @nanopore @pacbio and Loopseq - fraction of error-free reads. 'Any amplification is po… https://t.co/IGicY7hjot
10:51am October 27th 2022 via Twitter Web App
Yehezkel: Shows this '21 ref of RNA editing - is it from an alt allele or an edit. Shows viral isoform info - alt s… https://t.co/cMxTDnWpYx
10:49am October 27th 2022 via Twitter Web App
Yehezkel: Shows busy slide of many applications of the technology. Shows data from this 21 Comm Biol ref https://t.co/xz1CMN2mbw #ashg22
10:46am October 27th 2022 via Twitter Web App
RT @NeBanovich: No context #ASHG22 slides https://t.co/EqLjPXqGoY
10:41am October 27th 2022 via Twitter Web App
Yehezkel: Reviews Loopseq: UMI per strand of DNA; each molecule amplified; each copy has barcode copy/pasted ('dist… https://t.co/LE5l2yROrU
10:40am October 27th 2022 via Twitter Web App
Toval Ben Yehezkel "Loopseq Long Read Sequencing" #ashg22 (second half of @ElemBio workshop) Have devised a method… https://t.co/rr3nyR03p3
10:38am October 27th 2022 via Twitter Web App
Levy: Are looking at impact of insert size if the lengths are the same. "By improving the perf. of alignment and va… https://t.co/TuIQ9ZCs0n
10:31am October 27th 2022 via Twitter Web App
Levy: "Paired-end matters more than quality": perfect single-end reads are out-performed by lower quality PE reads.… https://t.co/CJ4yfGFs3F
10:29am October 27th 2022 via Twitter Web App
Levy: Reviews (briefly) somatic mutation detection, Reviews performance specs - along with transparent prices side-… https://t.co/zk91oVe5c7
10:28am October 27th 2022 via Twitter Web App
Levy: Benchmarking HG005 (reference genome) for WGS and looks at de novo trios, true vs false de novo muts across a… https://t.co/kcpL9eHvCM
10:26am October 27th 2022 via Twitter Web App
Levy: Now onto homopolymers - 'AVITI outperforms SBS in 97% of 700K loci following homopolymer lengths >11'. Shows… https://t.co/rHPJgUUh
10:24am October 27th 2022 via Twitter Web App
Levy: 2x300 kit will be announced in the next few weeks, available early in '23. 96.2% Q30 at 1x300; 82.4% Q40 at 1… https://t.co/s2gdssmgMZ
10:22am October 27th 2022 via Twitter Web App
Levy: Shows data from PCR-free library prep, and distribution of Q scores via QQ plot. (Impressive.) Previewing in-… https://t.co/BPAP7yXQMk
10:21am October 27th 2022 via Twitter Web App
Levy: Shows the balance between quality and density of reads. Shares @OlinkProteomics data across five 96-plex Olin… https://t.co/0vWIyozSoG
10:19am October 27th 2022 via Twitter Web App
Levy: Two workflows, one called 'Adept' where libraries are converted. Shows data on low background noise, low opti… https://t.co/7INeo7Z5DQ
10:16am October 27th 2022 via Twitter Web App
Levy: Two completely indep flowcells; 2B reads/run. $289K inst cost. $1080/120GB; $1680/240B. Q30 >90%. Shows nice… https://t.co/HTn5oBTc
10:15am October 27th 2022 via Twitter Web App
Levy: Rolling-circle ampl, bind avidite through mod polymerase, unique dye per base, image, remove avidite, then st… https://t.co/iDCWfvtBqR
10:12am October 27th 2022 via Twitter Web App
Levy: Improve on both dimensions - lower cost at the start. Shows how the innovation has been from first principles… https://t.co/7oBcFyv4xd
10:10am October 27th 2022 via Twitter Web App
Up early for an #ashg22 @ElemBio workshop with Shawn Levy (SVP of Applications, formerly of HudsonAlpha) Avidity se… https://t.co/HKyAprqMKs
10:08am October 27th 2022 via Twitter Web App
RT @AwadallaLab: @nickwfcheng is up presenting #ASHG22 his work showing that with our machine learning approaches can detect breast and oth…
2:35pm October 26th 2022 via Twitter Web App
Cheng: #ASHG22 Now did ML to ID early cancers. n=67 pre-dx breast cancers, n=59 matched controls. AUC 0.93, general… https://t.co/iCBH4Jg9Ve
2:32pm October 26th 2022 via Twitter Web App
Cheng: #ASHG22 Has samples from 2009, and 2019 measured breast, panc and prostate cancers. Used cfMeDIP-Seq. Shows… https://t.co/cFxMPgTbve
2:27pm October 26th 2022 via Twitter Web App
Cheng: #ASHG22 Developed ML model, problem is most blood is collected at time of Dx. Need to look in asymptomatic i… https://t.co/XygR2x1nAN
2:23pm October 26th 2022 via Twitter Web App
Cheng: #ASGH22 Global and focal changes in cancer methylomes occur early in tumor evolution; can be years before Dx… https://t.co/UJyM8IKs9e
2:21pm October 26th 2022 via Twitter Web App
Nicholas Cheng (Univ Toronto and Princess Margaret MC Canada) #ASHG22 Profiling pre-diagnosis plasma cell-free DNA… https://t.co/1BFc38DNAL
2:20pm October 26th 2022 via Twitter Web App
RT @OlinkProteomics: At this afternoon's 3:00pm-4:45 Poster Session #ASHG22, be sure to check out @taylorlawley's poster PB3176 - Using an…
2:17pm October 26th 2022 via Twitter Web App
Averting Alzheimer's as soon as possible Session at #ASHG22 Ben James (MIT/Broad) looks at snRNA and snATAC to caus… https://t.co/1dfSiLilVv
1:57pm October 26th 2022 via Twitter Web App
Q: #ASHG22 Analytical workflow from Dr. Truong, could multiple cluster analysis be tried? Truong: Not automated; fe… https://t.co/6G01FiE51A
11:06am October 26th 2022 via Twitter Web App
Horvath: #ASHG22 50% of mouse transcripts changed between 1pm and 3pm (!) in brain. "People underestimate the noise in mRNA data"
11:03am October 26th 2022 via Twitter Web App
Q: Non-spec aging in different people - leverage other kinds of clocks - does methylation capture it? Horvath… https://t.co/Yn4QZyV27C
Q: Measuring imputation of methylation vs genotypes? Horvath: #ASGH22 feels it is much more correlated than genotyp… https://t.co/qJ4VQYsPZD
11:00am October 26th 2022 via Twitter Web App
