Nelson: But 500K still isn't enough; real power will be agg. across 10's or 100's of biobanks. Genomics Resource Consortia #Genomicsfest
9:52am October 3rd 2017 via Hootsuite
Nelson: Shows this result from recent PLOS ref https://t.co/XmtUV0SFxK and did their own PheWAS recapitulating results #Genomicsfest
9:51am October 3rd 2017 via Hootsuite
Nelson: currently genotype data, EHR, self-reported, can do PheWAS. Compare 24 mos to 3h, recapitulated CHD data. #Genomicsfest
9:50am October 3rd 2017 via Hootsuite
Nelson: UK Biobank is 'the most exciting thing to happen to genetics since GWAS'. 500K participants, 'unprecedented resource' #Genomicsfest
9:48am October 3rd 2017 via Hootsuite
Nelson: Recent STOPGAP ref https://t.co/RKjHAQXzQc Looking at collaboration for GLPR1 activators for CHD - 24mo and slow #Genomicsfest
9:47am October 3rd 2017 via Hootsuite
Nelson: #Genomicsfest Developed a tool called StopGap2 - using open targets. Github site: https://t.co/GJN5TYVkNt https://t.co/Y9Jcju8Y4b
9:45am October 3rd 2017 via Hootsuite
Nelson: Pre-competitive vs competitive: finding genetic assoc'n, causal gene, mechanism: need for sharing broadly. #Genomicsfest
9:44am October 3rd 2017 via Hootsuite
Nelson: T2D '14 Nature Gen https://t.co/tgCtSsD3u2 Collective contributions to scientific commons 'can have dramatic impacts' #Genomicsfest
9:40am October 3rd 2017 via Hootsuite
Nelson: GWAS has ID'd thousands of variants influencing human traits. '14: 8% had genetic evidence; '16 12% had. #Genomicsfest
9:38am October 3rd 2017 via Hootsuite
Nelson: Currently about 15% of targets have genetic evidence. Est. can save 12-15% of overall costs if raised to 50% #Genomicsfest
9:36am October 3rd 2017 via Hootsuite
Nelson: '15 Nature Genet ref https://t.co/E9wPAVzf7U shows drugs are 2x more likely to be approved w/genetic evidence #Genomicsfest
9:35am October 3rd 2017 via Hootsuite
Nelson: Only about 10% overall probability of success at Ph1; 20% at Ph2; lack of efficacy at Ph3 probability is 50% faiil #Genomicsfest
9:33am October 3rd 2017 via Hootsuite
Nelson: "Moonshot is easy; making a drug is really hard." #Genomicsfest
9:31am October 3rd 2017 via Hootsuite
Nelson: Man on the moon is easier: Newtonian physics, an engineering problem. A single drug is $2.6B; SpaceX costs $135M #Genomicsfest
Nelson: 5K-10K compounds down to 250; at clinical trials 5 compounds another 6-7y (Ph1-Ph3). Thousands of volunteers #Genomicsfest
9:30am October 3rd 2017 via Hootsuite
Nelson: Credits Lon Cardon for the content; a moonshot is trying something that is hard. From disc to preclin: 3-6y #Genomicsfest
9:29am October 3rd 2017 via Hootsuite
Matt Nelson (GSK) Building the rocket: strategic considerations for using human genetics to guide drug discovery #Genomicsfest
9:26am October 3rd 2017 via Hootsuite
Cofactor sure does know how to title a talk correctly st #genomicsfest https://t.co/ov0quq615G
7:37am October 3rd 2017 via Hootsuite
We hail individual geniuses, but success in science comes through collaboration | The Guardian https://t.co/IZNNNf2kfH
9:17pm October 2nd 2017 via Hootsuite
Nice to meet you @dnabarcode on the phone today, IRL at #genomicsfest tomorrow! All the best - @DaleYuzuki
5:00pm October 2nd 2017 via Twitter Web Client
RT @PhilipHemme: Amazing Interview: The Man behind Next-Generation Sequencing and the $1,000 Genome https://t.co/Rk0ApyADap via @labiotech_…
4:25pm October 2nd 2017 via Twitter Web Client
RT @westr: Foundation Medicine Gets NY State Approval for #LiquidBiopsy Test https://t.co/2f0KQWZGU2 #PM101 All 50 states, now..
3:12pm October 2nd 2017 via Hootsuite
German Scrabble (cartoon by Manu Cornet) https://t.co/bvRxohawbV
8:40am October 2nd 2017 via Hootsuite
Work and the Loneliness Epidemic | HBR https://t.co/jWej6DvWnT
7:20am October 2nd 2017 via Hootsuite
The shorter your sleep, the shorter your life: the new sleep science | The Guardian https://t.co/2OrlH1gjMu
6:15am October 2nd 2017 via Hootsuite
Headed to Boston's #GenomicsFest Oct 3-4, looking forward to lots of interesting conversations! https://t.co/nyfVWC1Y6F
3:26pm September 30th 2017 via Hootsuite
RT @emilylmullin: After a planned DNA test giveaway to Ravens fans was postponed, I looked at state laws for consumer genetics tests. https…
1:41pm September 30th 2017 via Twitter Web Client
RT @NatureBiotech: Mouse phenotyping sheds light on rare disease https://t.co/JLM1M2uWsB #NBTNV https://t.co/mgqvx4YUM9
1:35pm September 30th 2017 via Twitter Web Client
RT @guardianscience: The curious case of the alien in the photo – and a mystery that took years to solve https://t.co/GnyO3uU7rC
1:32pm September 30th 2017 via Hootsuite
Wanted: 1 million people to study genes, habits and health | AP https://t.co/2h2ubc7L6L
11:10am September 29th 2017 via Hootsuite
Your Guide to Getting Sequenced – https://t.co/0RG0jAiDhC – Medium https://t.co/T8UDMkNZrY
10:10am September 29th 2017 via Hootsuite
Kill Time in Traffic by Diagnosing Cancer – https://t.co/0RG0jAiDhC – Medium https://t.co/M1UuN9j0C6
9:10am September 29th 2017 via Hootsuite
RT @EricTopol: The meteoric rise and dilemma of preprints in biomedical research https://t.co/fgnhHpZ7zH @sciencemagazine @ASAPbio_ @biorxi…
7:53am September 29th 2017 via Twitter Web Client
A Just-Discovered Papyrus Reveals How the Great Pyramid Was Built | Big Think https://t.co/BzMSutsFZn
7:25am September 29th 2017 via Hootsuite
The Post-Antibiotic Era Is Here. Now What? | WIRED https://t.co/l1ynHV0INb
6:15am September 29th 2017 via Hootsuite
The Rural Higher-Education Crisis - The Atlantic https://t.co/u4AXtDfJVw
5:15am September 29th 2017 via Hootsuite
DNA surgery on embryos removes disease - BBC News https://t.co/zh7OX2qufG
1:06pm September 28th 2017 via Hootsuite
Dog DNA Testing Market Grows As Vendors Target Consumers, Breeders, Vets | GenomeWeb ($) https://t.co/SSxjQ1RrTo
12:50pm September 28th 2017 via Hootsuite
Inova, Veritas Genetics Partner to Offer Whole-Genome Sequencing, Interpretation | GenomeWeb https://t.co/n8Mg5NfglG
11:36am September 28th 2017 via Hootsuite
Have Smartphones Destroyed a Generation? - The Atlantic https://t.co/ZTCws3WHpo
9:15pm September 27th 2017 via Hootsuite
Facebook, Welcome to Corporate Adulthood. It's Awful - Bloomberg https://t.co/M5CECfUDiO
9:35pm September 26th 2017 via Hootsuite
The Overload Principle: a secret to success| LinkedIn https://t.co/TVJtRlOWsu
8:24pm September 26th 2017 via Hootsuite
Sleep loss 'epidemic' shortens lives, causes disease, expert says | The Sacramento Bee https://t.co/EYYiQNVNwo
5:45pm September 26th 2017 via Hootsuite
RT @JAMA_current: Genetic factors may explain most of the risk for #autism spectrum disorder: https://t.co/IcfT6TwM8j in @TIME https://t.co…
3:08pm September 26th 2017 via Twitter Web Client
Post-Maria, med-tech firms in Puerto Rico work to track down workers - https://t.co/pNLp9WDrHr https://t.co/UDs2DPR0Oa
12:35pm September 26th 2017 via Hootsuite
RT @Jshatan: Well, this is making a splash. #science #research #genomics #DNA #sequencing https://t.co/XKqIZ4Q3m6
12:25pm September 26th 2017 via Hootsuite
How to Survive the Apocalypse - https://t.co/dDcpBPkdXU https://t.co/LBKNudHCMO
10:40am September 26th 2017 via Hootsuite
Futurist Ray Kurzweil Isn't Worried About Technology Stealing Your Job | https://t.co/4A5rkDrChb https://t.co/HzrkEJruDi
10:30am September 26th 2017 via Hootsuite
Are Facebook, Google and Amazon too big? Unease comes from left, right | USA Today https://t.co/hwnQXzf1Rl
Microsoft places its bets on quantum computing | TechCrunch https://t.co/JfCyXls7be
8:05am September 26th 2017 via Hootsuite
