Cochran #AACR23 Mice full of Myeloid Derived Suppressor cells (MDSC’s) - a good pro-tumor model. Shows treatment an… https://t.co/Uj5hocdUbR
8:28am April 19th 2023 via Twitter for iPhone
Cochran #AACR23 Use it for a TLR9 agonist; elicit Amit-tumor immunity via targeted immunostimulant therapy, ‘22 ref… https://t.co/rPTlajEwvw
8:25am April 19th 2023 via Twitter for iPhone
Cochran #AACR23 A “bonding site barrier” - increasing dosage of Ab-drug combo improves efficacy, but too high to be… https://t.co/97haJwvTv2
8:23am April 19th 2023 via Twitter for iPhone
Cochran #AACR23 a toolbox of drug conjugates- there’s an optimal range of protein / peptide - kDa in 10-100 is more… https://t.co/fEk2xjZchq
8:20am April 19th 2023 via Twitter for iPhone
Cochran #AACR23 Afemt from the seeds of a “squirting cucumber”. Binds trypsin called EETI-II 2009 Cancer Res 2009 https://t.co/7tR8I9gWkN
8:17am April 19th 2023 via Twitter for iPhone
Cochran #AACR23 Now - why not peptide-drug conjugates? Faster clearance, smaller proteins could penetrate tumors better.
8:15am April 19th 2023 via Twitter for iPhone
Cochran #AACR23 Fc fusions proteins are current blockbuster drugs, over 100 in development. https://t.co/0lmvVeZK1k
8:14am April 19th 2023 via Twitter for iPhone
Cochran #AACR23 1st gen molecule in 2014 https://t.co/xQ2f8X9Sx5 2nd gen is 2017 JCI version. Shows chart of # of m… https://t.co/IMSzswoUbz
8:13am April 19th 2023 via Twitter for iPhone
Cochran #AACR23 An engineered Axl “receptor decoy” - that looks a lot like an Ab - but a molecule that is in clinic… https://t.co/MSiD68kGue
8:10am April 19th 2023 via Twitter for iPhone
Plenary #AACR23 New Concepts in Drug Discovery and Engineering - first Jennifer Cochran (Stanford CA) Engineered pr… https://t.co/nnUOazn8vt
8:08am April 19th 2023 via Twitter for iPhone
Ulrich #AACR23 Session 7: tertiary prevention- biomarkers of relapse Session 8: AI and data science - the brave new… https://t.co/L8sKJq7mKG
7:16pm April 18th 2023 via Twitter Web App
Ulrich #AACR23 Session 4: preclinical/clinical partnerships in research: innovative team science; Session 5: health… https://t.co/Iv73k1kluX
7:15pm April 18th 2023 via Twitter Web App
Ulrich #AACR23 Ideas: Session 1, setting the stage for cancer prevention agenda; Session 2: early detection and ear… https://t.co/BAiAujsbMD
7:14pm April 18th 2023 via Twitter Web App
Cornelia Ulrich (Huntsman Cancer Inst UT) #AACR23 A brave new world of cancer prevention. As part of the population… https://t.co/FZzfqwWza4
7:12pm April 18th 2023 via Twitter Web App
Visvanathan #AACR23 Can it be used for early detection of breast cancer? Have started the effort.
7:10pm April 18th 2023 via Twitter Web App
Visvanathan #AACR23 The assay 'not good enough to disseminate'; had to develop a 5h test, 1 mL blood, POCT. Scalabl… https://t.co/30PuGUjMbo
7:05pm April 18th 2023 via Twitter Web App
Visvanathan #AACR23 TBCRC-005 prospective biomarker trial results: high CMI (cumulative methylation) at week 4 is a… https://t.co/QvQMliOBl4
7:03pm April 18th 2023 via Twitter Web App
Visvanathan #AACR23 Those you can measure, quantify. Development of panel '22 ref https://t.co/slI66n4yV9 Were thes… https://t.co/UMaNl3mlbk
7:02pm April 18th 2023 via Twitter Web App
Visvanathan #AACR23 Potential clinical utility of DNA methyltation across the breast cancer continuum. atypical hyp… https://t.co/MdMerMqZK8
6:59pm April 18th 2023 via Twitter Web App
Town Hall at #AACR biomarkers and early detection tests for cancer prevention: Kala Visvanathan (Johns Hopkins Univ… https://t.co/NvKoA2tkBJ
6:57pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Indirectly target transc factors by the mediators of the enhancer networks, by targeting SWI/SN… https://t.co/PXZwyqytnV
5:50pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Next: targeting transcription factor 'neo-enhanceosome'.
5:47pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Shows AUC of 80.2% in training of the v2 test. PSA is 0.60. n=743, blinded cohort, 18-transcript… https://t.co/wXnbCdoVe9
5:45pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Improved version with 'MPS-50' with an additional 50 transcripts to improve test, to run on a cu… https://t.co/GZc23SoE0k
5:43pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Have dev a multiplexed urine biomarker for clinically sig prostate cancer TMPRSS2:ERG and lncRNA… https://t.co/FJlSajvdUO
5:42pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Char FOXA1 as an early driver of prostate cancer progression '19 Nature https://t.co/xxHPLOIYdk
5:39pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Clinical lessons '15 Cell ref https://t.co/02Mo0mGRBL
5:38pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Overexp of the gene fusion product ERG, induces prostate cancer in aged mice. One of the first t… https://t.co/vRumIV4pEG
5:34pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Found an imbalance in exons in TEMPRESS2 fused to ERG and ETV1; used 5' RACE to discover, FISH t… https://t.co/6wnKTe1zmR
5:29pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Looked for outlier gene exp, and bioinformatics approach led to discovery of gene fusions in pro… https://t.co/02RBEW4fOP
5:28pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Charles Huggins Nobel Prize winner 1966, androgens are important for prostate ca growth. Discove… https://t.co/lbUq6X7xY7
5:27pm April 18th 2023 via Twitter Web App
Chinnaiyan #AACR23 Chr aberrations in cancer - 1900's hypothesized. Since 2000's, recurrent structural aberrations… https://t.co/bZvVsJKP2j
5:25pm April 18th 2023 via Twitter Web App
Arul Chinnaiyan (Univ Michigan MI) #AACR23 Gene Fusions in solid tumors - implications for precision oncology. On t… https://t.co/xknpu9ME5F
5:22pm April 18th 2023 via Twitter Web App
AACR - James S Ewing-Thelma B Dunn Award for Outstanding Achievement in Pathology in Cancer Research #AACR23 Dr. Arul Chinnaiyan
5:21pm April 18th 2023 via Twitter Web App
Rapisarda #AACR23 Q: Both from pt tissue versus PDX, any differences? A: Quite similar, not much variation by seque… https://t.co/nd9Ij3cyix
3:33pm April 18th 2023 via Twitter Web App
Rapisarda #AACR23 Q: Have they been sequenced? A: WES and RNA-Seq. Q: Same media for different organ types? A: Very… https://t.co/dSnxBVZjDf
Rapisarda #AACR23 Cp to NCI-60: shows similarities, difference of colon adenocarcinoma organoids cp to NCI-60 lines… https://t.co/f4v14NODRY
3:31pm April 18th 2023 via Twitter Web App
Rapisarda #AACR23 PDOrgs <100um, 5% Cultrex RGF BME, Type 2, tested against 166 FDA-approved oncology drugs (100 uM… https://t.co/t1WNEYT
3:26pm April 18th 2023 via Twitter Web App
Rapisarda #AACR23 Has rare and recalcitrant tissue-derived organoids. website: https://t.co/UP5wxfLn63 248 public p… https://t.co/WHCM5MROP3
3:23pm April 18th 2023 via Twitter Web App
Annamaria Rapisarda (Frederick Nat'l Lab for Cancer Research MD) #AACR23 Advancing a screening platform with panels… https://t.co/3z1tZpVcxO
3:22pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Q: What kind of timeline for approval? Medicare reimbursement push you? Diaz: "I think they got… https://t.co/ol6vL6tLkB
1:56pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Q: Can you see a pairings of tests? Castle: Could be triage for positive mammography, could be a screen for spiral CT.
1:50pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Diaz 3: A different level of financial commitment and commitment from payors (for these kind of MCEDs)
1:46pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Diaz 2: Often enrichment tests - 20 pack-years, or genetic predisp, or >45 yo, or sexually activ… https://t.co/BbBZFrj
1:45pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Castle: Great value for low-risk people to relax a bit. Diaz: Low risk is difficult to define. L… https://t.co/muU9jTLfmN
1:44pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Q (from Delphi Dx person) Why not single cancer where there may be more benefit? Spec / Sens tur… https://t.co/ESUn1LHWGB
1:39pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Q: is there a middle ground or wait for years? Castle: Say there may be many tests for many diff… https://t.co/NK9rQhlsNI
1:33pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Bradbury: Luis Diaz commented that 'we may be biting off more than we can chew' and the costs an… https://t.co/hxkSX2xxr8
1:27pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Bradbury: Want to collect data in a registry. Wood: The diagnostic workup is complex. Pathfinder… https://t.co/v9IptU9vhq
1:26pm April 18th 2023 via Twitter Web App
MCED Panel #AACR23 Castle: NCI knows about 25 MCED tests. Must be another 25 academic centers working on it. LDT pa… https://t.co/2fg5I01NWM
1:21pm April 18th 2023 via Twitter Web App
