Wookey #worldcdx Dual plex IHC, RNA ISH, Multiplex ISH: may need a different approval path.
12:20pm September 11th 2019 via Twitter Web App
Wookey #worldcdx Shows large menu of capability to support CDx. Multiplex IHC: to char cell-cell interactions. Has a place in clin dev
12:19pm September 11th 2019 via Twitter Web App
Wookey #worldcdx Liquid biopsy: agnostic (Archer, Oncomine, TSO500, PGDx Elio). 'Each tech has strengths dep on intended use'
12:18pm September 11th 2019 via Twitter Web App
Wookey #worldcdx One acquisition: Biofortis, to rescue failed/suboptimal trials. Pull samples, get e-consent
12:17pm September 11th 2019 via Twitter Web App
Wookey #worldcdx Multiple tech for one biomarker: a new paradigm? Challenges: local handling of blood for cfDNA
12:16pm September 11th 2019 via Twitter Web App
Wookey #worldcdx PD-L1 capability >50 studies in China 2014-19. NMPA '18 4 CDx approvals, all retrospective. No 'co-dev' there.
12:15pm September 11th 2019 via Twitter Web App
Wookey #worldcdx Q2 put lab with many different technology - IHC, FISH, Elisa, PCR, NGS, Nanostring: an regulatory expertise nearby
12:14pm September 11th 2019 via Twitter Web App
Wookey #worldcdx Now in 2019: 400 Ph I studies, some bias towards gastric and head&neck. Molecular targets all amenable to CDx
12:13pm September 11th 2019 via Twitter Web App
Wookey #worldcdx China: have started at PMU in Beijing. Iressa IPASS Ph 3 trial 2005-09.
Wookey #worldcdx Showed cancellation rate decreasing by 50% as a result.
12:11pm September 11th 2019 via Twitter Web App
Wookey #worldcdx Insuff / poor quality sample: education pkgs, investigator mtgs, standardizing collection
12:08pm September 11th 2019 via Twitter Web App
Wookey #worldcdx One thing that hasn't changed: 3/4ths are IHC-based. Ex. PD-L1, 30K tested, 6 assays. 4.2% cancellation rate data
Wookey #worldcdx Evolving complexity: from targeted Rx now to I-O: better defined samples and preanalytics; HTP tes… https://t.co/yQRvcO86t6
12:02pm September 11th 2019 via Twitter Web App
Wookey #worldcdx Pharma (science/clinical/regulatory/commercial), works with CRO and IVD partner.
11:59am September 11th 2019 via Twitter Web App
Alan Wookey (Q2 Solutions) #worldcdx Delivering Successful Companion Diagnostics Programs: A Large Global Central Laboratory’s Experience
11:58am September 11th 2019 via Twitter Web App
Wohlgemuth #worldcdx Pts are getting clin trials info on the internet anyway...
11:51am September 11th 2019 via Twitter Web App
Freeman #worldcdx They also have a pharma analytics and clinical trial service offering Clinical Trials Connect https://t.co/UGfCtii3TB
11:49am September 11th 2019 via Twitter Web App
Freeman #worldcdx De-ID'd data - can see what AE info, outcome info over time. Illus w/Hep B and D for Eiger's enro… https://t.co/GBuJX65P4l
11:46am September 11th 2019 via Twitter Web App
Freeman #worldcdx Only 33% of Americans are aware of clinical trials. Expert determination: de-identified Pt info, generate a hashed token
11:41am September 11th 2019 via Twitter Web App
Wohlgemuth #worldcdx They have developed a Global Diagnostics Network for clin trial enrollment. Next: David Freema… https://t.co/TUMznA9jxK
11:36am September 11th 2019 via Twitter Web App
Wohlgemuth #worldcdx At the population level (36K US members) ID'd ~7500 unrecognized cases of chronic disease.
11:27am September 11th 2019 via Twitter Web App
Wohlgemuth #worldcdx Showed reduction of 1% in overall claims (first time in 10y).
Wohlgemuth #worldcdx They apply their own services to their own employees - example of Blueprint for Wellness. Show… https://t.co/Vq2UPszJua
11:26am September 11th 2019 via Twitter Web App
Wohlgemuth #worldcdx Testing for diabetes, collect at home and sent back at RT, https://t.co/UGYYFkD6q6 for YouTube video
11:24am September 11th 2019 via Twitter Web App
Wohlgemuth #worldcdx 'There is something to be said about convenience'. Home-based self-collection the most convenient.
11:23am September 11th 2019 via Twitter Web App
Wohlgemuth #worldcdx All the annotation assoc'd with a phenotype. 6/10 adults in the US have a chronic disease; 4/10 have two or more (!)
11:17am September 11th 2019 via Twitter Web App
Wohlgemuth #worldcdx Shows a busy slide of all that it involves to implement genetic testing as a diagnostic. And on top: a data commons
11:16am September 11th 2019 via Twitter Web App
Wohlgemuth #worldcdx Not only diagnostic services but also information services, and population health.
11:15am September 11th 2019 via Twitter Web App
Jay Wohlgemuth (CMO) and David Freeman (Quest Diagnostics) Enabling population health and precision care #worldcdx
11:13am September 11th 2019 via Twitter Web App
Toft #worldcdx Concludes with one word: Confidence. Along with competence and commitment, 'we'll all win'.
11:11am September 11th 2019 via Twitter Web App
Becker #worldcdx Creating value is good; sometimes it's good to talk about what you have done (and take credit for it)
11:03am September 11th 2019 via Twitter Web App
Toft #worldcdx 25% of your time needs to be spent on development 'of yourself'. Apply yourself - to create value fo… https://t.co/WqqYOpt6dD
11:01am September 11th 2019 via Twitter Web App
Ballmer #worldcdx A mentor of hers said 'at the C-level, 30% of your time needs to be spent networking'
11:00am September 11th 2019 via Twitter Web App
Rosen: #worldcdx Attracting and retaining: a larger topic. Flexibility; the right kinds of benefits; and feeling th… https://t.co/fRHAG65rgk
10:57am September 11th 2019 via Twitter Web App
Greenfield #worldcdx Very few measure and track - but when it does happen things do change. Recruiting and promotio… https://t.co/acAmTnaca7
10:55am September 11th 2019 via Twitter Web App
Toft #worldcdx Exec search needs to reflect diversity. Increasing innovation, better financial perf (!), better talent.
10:52am September 11th 2019 via Twitter Web App
Ballmer #worldcdx Roche, Agilent: if you don't have women in the succession plan, there won't be women in leadership.
10:49am September 11th 2019 via Twitter Web App
Greenfield #worldcdx Not due to opting-out; the criteria for promotion is the same; it is SVP/C-Suite: a dramatic s… https://t.co/tA1SS8HLfE
10:48am September 11th 2019 via Twitter Web App
Greenfield #worldcdx 22% women at the board level, from 54% at entry-level. C-suite 30-something. Attrition not the problem.
10:47am September 11th 2019 via Twitter Web App
Becker #worldcdx Orgs can facilitate mentorship; Abbott hosts panels to invite meeting Sr mgmt, peer groups, to have open conversations
10:45am September 11th 2019 via Twitter Web App
Rosen #worldcdx "Million girls in STEM", J&J provides mentorship among high-schoolers.
10:44am September 11th 2019 via Twitter Web App
Rosen #worldcdx Not enough women in STEM: first is environmental (culture); then giving opportunity via programs. H… https://t.co/OMILMLKixL
10:42am September 11th 2019 via Twitter Web App
Keynote at #worldcdx on Women in Precision Medicine: Kathryn Becker Abbott Molecular; Allison Ballmer Agilent; Robi… https://t.co/0uSTe4K415
10:41am September 11th 2019 via Twitter Web App
Q: NILE study G360 mut+ respond to TKI's? Helman #worldcdx 5/6 discordant, did respond (false negative in tissue)
9:51am September 11th 2019 via Twitter Web App
Q: Move toward niche disease? Helman #worldcdx They strive for being comprehensive.
9:50am September 11th 2019 via Twitter Web App
Helman #worldcdx Shows data PFS/OS of G-Omni presented yesterday at https://t.co/9YDqA3cbJx TMB mut +/- neg predict… https://t.co/AHckLF8OMZ
9:49am September 11th 2019 via Twitter Web App
Helman #worldcdx Shows results from Kuziora AACR 2017 on I-O response and ctDNA mutation status.
9:45am September 11th 2019 via Twitter Web App
Helman #worldcdx Largest blood-based MSI to traditional tissue testing Willis CCR '19. https://t.co/kf8WNOkKhj
9:44am September 11th 2019 via Twitter Web App
Helman #worldcdx of 323 NSCLC at U Penn, 44% insuff tissue. 90% concordance via SoC tissue. 2x the muts detected.
9:40am September 11th 2019 via Twitter Web App
Helman #worldcdx More pts detected NCCN biomarkers: of >200, 77 vs 60; 9 vs 15 day TAT. Leighl '19 CCR pursuing a blood-first paradigm
9:39am September 11th 2019 via Twitter Web App
