Recent Tweets Page 89

Rehm #AGBTph18 Incredibly useful, critical to bring knowledge together. The importance of data-sharing - and its value.

8:55pm September 7th 2018 via Twitter Web Client

Berger #AGBTph18 Is there a gold std for TMB? One test to recalibrate everything - 'we're still grappling'

8:52pm September 7th 2018 via Twitter Web Client

Berger #AGBTph18 Depriving pt b/c of low TMB, how good is TMB as a biomarker? 16 mut/Mbase dep on type of cancer. TMB is assay-dependent.

8:51pm September 7th 2018 via Twitter Web Client

McLeod: Heterogeneity? Berger #AGBTph18 TMB is a focus now: due to ImmunoRx response. We 'struggle with that' as low TMB may still respond.

8:50pm September 7th 2018 via Twitter Web Client

McKenzie #AGBTph18 Could be a good cand for I-O studies. MYC: pharma is looking for MYC ampl for clin trial Rx

8:49pm September 7th 2018 via Twitter Web Client

McKenzie #AGBTph18 With Ras, BRAF, MET ampl, this says 'cancer doing everything to survive'.

8:48pm September 7th 2018 via Twitter Web Client

McLeod #AGBTph18 Sees TP53, KRAS, MYC ampl, BRAF and MET ampl, EGFR muts incl T790M. McKenzie: loathe to focus on one mutation

8:47pm September 7th 2018 via Twitter Web Client

McLeod #AGBTph18 Shows chart of case 1 w/list of genes mutated, AF, protein domain, MSS (stable), TMB intermediate 16.

8:46pm September 7th 2018 via Twitter Web Client

McKenzie #AGBTph18 Liq Biopsy - 'just b/c it's easy doesn't mean it is something we need to do' balanced with 'better than nothing'.

8:45pm September 7th 2018 via Twitter Web Client

Rehm #AGBTph18 Other types of controls at the Broad: individual signatures for each pt, an individual MRD assay.

8:43pm September 7th 2018 via Twitter Web Client

Rehm #AGBTph18 One thing to think about is contamination rate, when very low levels are being detected. Positive controls are problematic.

8:42pm September 7th 2018 via Twitter Web Client

Berger #AGBTph18 Some level of discordance to expect; driver muts. Cancer community has adopted this.

8:41pm September 7th 2018 via Twitter Web Client

Howard McLeod (Moffit) moderator #AGBTph18 A mock tumor board, with Heidi Rehm (MGH) Michael Berger (MSKCC) Andrew McKenzie (Sarah Cannon)

8:36pm September 7th 2018 via Twitter Web Client

Kathiresan #AGBTph18 LPL, APOA5, LPA; four genes. Of 100 pts, monogenic familial hypercholesterolemia in 1.7% (manuscript in review)

6:43pm September 7th 2018 via Twitter Web Client

Kathiresan #AGBTph18 Genetic paths: case/controls n=5000/5000: LDLR 3.2x-fold '15 Nature https://t.co/aHpAh0SD8V

6:41pm September 7th 2018 via Twitter Web Client

Kathiresan #AGBTph18 MI is complex; 1/2 of MI cases, 1st presentation is fatal. '97 MGH started enrolling early-onset MI <50yo

6:39pm September 7th 2018 via Twitter Web Client

Kathiresan #AGBTph18 ACC/AHA ASCVD risk: pt was only 1.7%. Was it monogenic to MI? Polygenic component? Do somatic muts contribute?

6:37pm September 7th 2018 via Twitter Web Client

Sekar Kathiresan (MGH) #AGBTph18 Genetic basis for heart attack

6:35pm September 7th 2018 via Twitter Web Client

Flicek #AGBTph18 htsget: a standardized interface for secure data streaming, part of the large-scale genomics workstream.

6:26pm September 7th 2018 via Twitter Web Client

Flicek #AGBTph18 Shows busy slide of driver projects - @AllofUsResearch BRCA Challenge, NCI Genomic Data Commons...

6:19pm September 7th 2018 via Twitter Web Client

Flicek #AGBTph18 Upcoming @GA4GH 6th plenary 3-5 Oct '18 https://t.co/RUzfi2paei

6:17pm September 7th 2018 via Twitter Web Client

Flicek #AGBTph18 Federation allows analysis moved to data; reciprocal access; transfer of methods into healthcare.

6:14pm September 7th 2018 via Twitter Web Client

Flicek #AGBTph18 We can get a >60M virtual cohort by 2025; humans 'will be the best studied organisms on the planet due to healthcare'

6:12pm September 7th 2018 via Twitter Web Client

Flicek #AGBTph18 BioRxiv preprint on GA4GH looks to 2022: https://t.co/hwnbX5lEyK

6:11pm September 7th 2018 via Twitter Web Client

Flicek #AGBTph18 Informatics is infrastructure: archives, standards, formats, metadata. 1984: a print-out of EMBL's GenBank.

6:07pm September 7th 2018 via Twitter Web Client

Flicek #AGBTph18 "Growth repeatedly exposes inadequate infrastructure to support the needs of new technologies"

6:05pm September 7th 2018 via Twitter Web Client

Flicek #AGBTph18 1909 "The automobile has reached the limit of its development" Scientific American

6:04pm September 7th 2018 via Twitter Web Client

Flicek #AGBTph18 History of a foundational modern tech; 1879 first gasoline engine (Benz); 1885 first automobile; 1908 Ford model T.

6:04pm September 7th 2018 via Twitter Web Client

Paul Flicek (EBI-EMBL) #AGBTph18 Empowering data sharing for genomic medicine

6:01pm September 7th 2018 via Twitter Web Client

Hi #AGBTph18 - @Pillar_Bio will present ‘Eval of a high-thruput NGS SLIMamp CFTR assay’ poster at the break #155 https://t.co/y8uPkcYLqq

4:25pm September 7th 2018 via Twitter for iPhone

Ramakrishnan #AGBTph18 Confirmed segmental duplication. Partial reciprocal translocation near ETV1/FOXA1.

4:19pm September 7th 2018 via Twitter Web Client