Chanock:'Famous' chart of rare vs. low freq vs. common variants against effect size: common and uncommon cancers #trentlecture
1:25pm February 11th 2015 via Hootsuite
Chanock:Should we sequence more than TP53? "The answer is of course, yes" #trentlecture
1:24pm February 11th 2015 via Hootsuite
Chanock: Layer on age w/g-type, young onset osteosarcoma has distinct germline genetic etiology. Consider: genetic counseling #trentlecture
Chanock:Sequenced all Li-Fraumeni mutations, looked at Germline TP53. 10% of children, harbored TP53 mut's #trentlecture
1:22pm February 11th 2015 via Hootsuite
Chanock: Germline susceptibility 'not with ILMN, but with @iontorrent, yes other technologies do work' (ha!) of Osteosarcoma #trentlecture
1:21pm February 11th 2015 via Hootsuite
Chanock:Also environmental effects, other modifier genes interact with BRCA w/ other types of cancer that track w/it. #trentlecture
1:19pm February 11th 2015 via Hootsuite
Chanock: In the ~115 genes for germline - BRCA isn't 100% - impt where the mutation takes place; incomplete 'penetrance' #trentlecture
1:18pm February 11th 2015 via Hootsuite
Chanock: Other two quadrants: clinically actionable. ~26 (BRCA1/2, Lynch) at germline. Somatic: TCGA http://t.co/Ee9XOU1pW8 #trentlecture
1:17pm February 11th 2015 via Hootsuite
Chanock: 4 spaces: ~115 cancer syndromes explaining familial clustering; >470 regions of GWAS loci. Somatic (TCGA, COSMIC) #trentlecture
1:14pm February 11th 2015 via Hootsuite
Chanock: 'But we are at odds with industry' - lagging behind with pharmacogenomics (PGx), both a scientific and cultural problem.
1:13pm February 11th 2015 via Hootsuite
Chanock: '69 Li-Frumeni (TP53), '71 Knudsen 'two-hit'. Population-based screening has public-health implications; also etiology and PGx
1:12pm February 11th 2015 via Hootsuite
Chanock: "The Complexity of Genetic Susceptibility to Cancer" How the germline informs cancer. Starts with 1866 Broca and breast ca.
1:09pm February 11th 2015 via Hootsuite
Stephen Chanock @NCIChanock introduced as a 'Renaissance Man', with an undergraduate degree in music (!) http://t.co/mmZmSbDJTS
1:05pm February 11th 2015 via Hootsuite
Pleased to attend! MT @NCIEpiTraining TODAY @ 1pm Dr. Stephen Chanock, Jeffrey M. Trent Lecture in #Cancer Research http://t.co/FdZ6x1noFn
1:02pm February 11th 2015 via Hootsuite
RT @lisabriercliffe: These incredible National Geographic photos were shot by kids | Mashable http://t.co/w1kh7G0uPg
12:45pm February 11th 2015 via Hootsuite
Masys: Concludes with 'somber note' on cybersecurity. Attacks will be a persistent threat. 'Highly intolerant of error' #PMINetwork
11:11am February 11th 2015 via Hootsuite
Sachin Kheterpal (UMich): Concludes with industry engagement. Industry needs feedback on participants (they need to see value) #PMINetwork
11:10am February 11th 2015 via Hootsuite
RT @ScripDonnaDC: Masys: 1%-5% errors of individual #EHR data; sometimes simple mistakes; Making sure linkage occurs beginning of data inte…
11:07am February 11th 2015 via Twitter Web Client
Blue Button is a collection of specifications, mostly 'document-centric'. For Precision med need a data-centric method. #PMINetwork
11:06am February 11th 2015 via Hootsuite
Masys: 'Blue Button" function: rights to access copies of EHR data. Idea: "Synch for Science" (S4S) to transmit to data center #PMINetwork
11:04am February 11th 2015 via Hootsuite
Josh Denny: Need site-specific expertise to mine data on a site-specific basis. (Comment: a HARD problem.) #PMINetwork
11:03am February 11th 2015 via Hootsuite
Masys: Data from heterogeneous systems: data privacy a problem; combination of structured & unstructured data. #PMINetwork
11:02am February 11th 2015 via Hootsuite
Chisholm:Trade-offs of standardized data from everyone via EHR, or an open possibility across existing cohorts. #PMINetwork
10:59am February 11th 2015 via Hootsuite
Masys: Challenge of human & business models: a new consent model infrastructure. #PMINetwork
10:58am February 11th 2015 via Hootsuite
Daniel Masys: "Opportunities and challenges related to the use of electronic health records data for research" #PMINetwork
10:57am February 11th 2015 via Hootsuite
Q (Google Life Sciences):Phenotypic variability built-into this cohort? A: We're building a platform, can't predict outcome. #PMINetwork
10:52am February 11th 2015 via Hootsuite
Q: Where's the center for std. of data and data-quality? Patrick: Effort is starting, getting better, RW Johnson involved #PMINetwork
10:50am February 11th 2015 via Hootsuite
Ledbetter: The point is how to integrate data-collection into participant's daily life, w/o interruption of 'workflow'. #PMINetwork
10:48am February 11th 2015 via Hootsuite
Comment: "48% responded to web-based questionnaire; the subset w/smartphones had much better health (metrics)". #PMINetwork
10:47am February 11th 2015 via Hootsuite
Patrick:Tomorrow - a notion for making it 'as lightweight as possible'; also UX and UD very impt. Engagement is not unsolvable #PMINetwork
10:43am February 11th 2015 via Hootsuite
Chris Austin (NCATS)'s Q: "We'll run into realities of human behavior. Regular people won't continue this. A huge problem." #PMINetwork
10:42am February 11th 2015 via Hootsuite
Rick Cnossen from Intel: We need to have a crisp standardized dataset; yet w/sth. new, it will evolve & change. #PMINetwork
10:40am February 11th 2015 via Hootsuite
Patrick:Also mentions a new culture of participatory research, including competitions for continued engagement. #PMINetwork
10:39am February 11th 2015 via Hootsuite
Patrick:Genome, microbiome, EMR, behavioral, social, precise geospatial, multiple influences between & among these understood #PMINetwor
10:38am February 11th 2015 via Hootsuite
Patrick: Companies that capture data 'typically own it' - how do we access it for research? >All< data need opening up. #PMINetwork
10:37am February 11th 2015 via Hootsuite
Patrick: Now with mobile: GPS, sensors, ECG; a digital rendering. Need stds for sensor data 'a Wild West out there' #PMINetwork
RT @wilbanks: Pearl’s talking about our white paper on patient engagement. Read it at http://t.co/xayBo1wzQz and ask us questions. #PMINetw…
10:32am February 11th 2015 via Twitter Web Client
Patrick: Cellphone penetration, correlated to genome data. Then presented challenges of trad longitudinal assessment #PMINetwork
10:30am February 11th 2015 via Hootsuite
Kevin Patrick: The world has gone mobile: can engage cohorts undreamed of just a few years ago. #PMINetwork
10:29am February 11th 2015 via Hootsuite
Pettigrew:Creating of a new public culture: participation in a new kind of research. Data collection / mobile is critical. #PMINetwork
10:27am February 11th 2015 via Hootsuite
Roderic Pettigrew: "Data collection and mobile technologies". For this, tying in many types of data. Sensors, genetic, social #PMINetwork
10:26am February 11th 2015 via Hootsuite
Roderic Pettigrew: "Data collection and mobile technologies
10:23am February 11th 2015 via Hootsuite
O'Rourke: 'We have to have a reason (for them) to sign up and continue on'; 'here's my membership card & I'm proud of it' #PMINetwork
10:15am February 11th 2015 via Hootsuite
O'Rourke:Q:Few physicians (<10%) involved w/any clinical research A:Empowered participants will drag clinicians along. #PMINetwork
10:11am February 11th 2015 via Hootsuite
.@BioWorld (P O'Roarke is at Partners in Boston by the way.)
10:09am February 11th 2015 via Hootsuite in reply to
O'Rourke:Q:Mention of 'protocol' at odds w/participation? A:Can't approve an idea; need a clear plan for data collection. #PMINetwork
10:08am February 11th 2015 via Hootsuite
O'Rourke:'an incredible opp'y to responsibly advance genomics into precision care'. Also: create new paradigm for engagement #PMINetwork
10:05am February 11th 2015 via Hootsuite
O'Rourke: First proposed sol'n: 'Streamline research oversight that maintains protection.' acknowledges difficulty of this task. #PMINetwork
10:02am February 11th 2015 via Hootsuite
O'Rourke:Current oversight process (fed, state laws) far from optimal for large, distributed study. #PMINetwork
10:01am February 11th 2015 via Hootsuite
O'Rourke: Mentioned multi-platform access and gamification for data collection to make it fun - to get ongoing involvement #PMINetwork
10:00am February 11th 2015 via Hootsuite
