Bry: Drugs are biotransformed: NSAIDS, irinotecan, sulfasalzine, digoxigenin - first 2 mediated toxicities, 2nd reduced efficacy #Tricon
7:04pm February 20th 2017 via Hootsuite
Bry: Applications - biomarkers for dysbiotic conditions; ID of metabolites and biomarkers; push back to symbiotic commensalism #Tricon
7:02pm February 20th 2017 via Hootsuite
Bry: 'I don't want you to leave with the sense that the microbiome is still in the realm of vaporware' when it (clearly) is not. #Tricon
Bry: Able to go into defined cocktails w/commensals to reduce transmission of drug resistence, perhaps Rx interventions #Tricon
7:01pm February 20th 2017 via Hootsuite
Bry: For the C Diff model, organisms that affect C Diff either up or down. '16 Genome Biol ref https://t.co/cZEoRYyHkV #Tricon
6:58pm February 20th 2017 via Hootsuite
Bry: Did Bayesian projection of potential trajectories of infinite mixture model engine '12 PLOS ref https://t.co/WeLneW6WEH #Tricon
6:57pm February 20th 2017 via Hootsuite
Bry: Can a computational model be built to predict outcome? Put together putative protective communities, test in preclin model #Tricon
6:55pm February 20th 2017 via Hootsuite
Bry: Want to know essential composition; still need to go from donor to donor. Bringing together experimental, Pt and informatics #Tricon
6:54pm February 20th 2017 via Hootsuite
Bry: C diifficile, showing a yellow colon (with pus, yikes). First-line antibiotics, but FMT now std Rx recurrent. 80-90% effective #Tricon
6:53pm February 20th 2017 via Hootsuite
Bry: Now 'treat to cure': shows one spp was able to prevent IgE production. Human commensal bacteria: can it be done on people? #Tricon
6:52pm February 20th 2017 via Hootsuite
Bry: Showing IgE production against ovalbumin; small intestine mast cell recruitment shown, where anaphylaxis prevented (!) #Tricon
6:51pm February 20th 2017 via Hootsuite
Bry: Going to a Rx 'treat to prevent'; 8w period then followed by oral challenge, w/ an anaphylaxis temp drop. (Mouse model) #Tricon
6:50pm February 20th 2017 via Hootsuite
Bry: Gnoto-complex flora 44 human-culturable strains across 7 phyla, capitulating human microbiota by site, biochem and physiol fn #Tricon
6:49pm February 20th 2017 via Hootsuite
Bry: Foof sens., Th2 resp, IgE Ag, Mast cell recruit; re-exposure; allergic anaphylaxis. Looking at B-cell /IgA tolerance #Tricon
6:48pm February 20th 2017 via Hootsuite
Bry: ID'd Dx and Rx targets; admin. in mouse model; now looking at prospective clinical trials to prevent or cure food allergy #Tricon
6:47pm February 20th 2017 via Hootsuite
Bry: Environments may be too asceptic; doing 150 children longitudinal study; susceptible to food allergy, followed 3y #Tricon
6:46pm February 20th 2017 via Hootsuite
Bry: Food allergies cost $25B in lost time, illness. 6% children, 3% teens and adults. Epidemiology: caesarian reduced diversity #Tricon
Bry: Gnotobiotics, in vitro systems, synthetic biology. Going to clinical trials, and help direct what they will use. #Tricon
6:45pm February 20th 2017 via Hootsuite
Bry: Start w/large cohort w/clinical disease. Novel computational models (longitudinal, multiple variables, fn biology) #Tricon
6:44pm February 20th 2017 via Hootsuite
Bry: Rx could be prebiotics, probiotics, antibiotics, immunotherapeutics. Dietary changes, bugs as drugs, FMT #Tricon
6:43pm February 20th 2017 via Hootsuite
Bry: Also infection and immunity - dysbioses, susceptibility to infections (dysentery), pathobionts (IBD triggering flares) #Tricon
Bry: High sugar diet - lead to fermentation in-gut - potential cause of NASH nonalcoholic steatohepatitis #whatamouthful #Tricon
6:42pm February 20th 2017 via Hootsuite
Bry: Dental caries, to CV health, to digestive disorders. Functions - short chain fatty acids (sc-FA's). Ethanol production #Tricon
6:41pm February 20th 2017 via Hootsuite
Bry: Introduces with figure from '12 Nature https://t.co/RZ18x4tdvX Large chart of microbiota's involvement w/disease #Tricon
6:40pm February 20th 2017 via Hootsuite
Lynn Bry (Brigham & Women's Hosp MA) Precision microbiota applications in clinical therapy and diagnosis #Tricon
6:38pm February 20th 2017 via Hootsuite
Mata: Goal to generate testable hypotheses early; project teams need to engage support; need to engage regulatory, commercial teams #Tricon
6:37pm February 20th 2017 via Hootsuite
Mata: Key success factors for PM: starts at target selection; all projects in all Rx areas are in-scope for assessing;... #Tricon
6:36pm February 20th 2017 via Hootsuite
Mata: Shows slide of low- to med- to high-risk pts, from low likelihood of bacterial infection, to high, incr. sophistication PMDx #Tricon
6:33pm February 20th 2017 via Hootsuite
Mata: Current antibiotic Rx is 'educated guess'. Fig from '16 J Prec Med (PDF: https://t.co/8vLvfYNQ5b ) #Tricon
6:31pm February 20th 2017 via Hootsuite
Mata: Case study 3: Dx are 'crucial to solving the problem of antibacterial resistance'. Hazards: from concerning, serious, urgent #Tricon
6:29pm February 20th 2017 via Hootsuite
Mata: The first CDx for NGS: Oncology FoundationFOCUS CDx BRCA detects deleterious BRCA1/2, either germline or inh. (Myriad mention) #Tricon
6:28pm February 20th 2017 via Hootsuite
Mata: Combination for deltaF508 CF mutation. #Tricon The first NGS approval: came from CF in '12, MiSeqDx. 139-var assay.
6:26pm February 20th 2017 via Hootsuite
Mata: CF:the 'rare among the rare'. Kalydeco, '12 approved, 10 specific mutations (G551D, G1244E etc); also combination w/Orkambi #Tricon
6:25pm February 20th 2017 via Hootsuite
Mata: 2nd drug Maraviroc, '07 approved; '15 removed CDx PMA. Tropism assay 'required' = Companion Dx #Tricon
6:24pm February 20th 2017 via Hootsuite
Mata: One disease (HIV), two drugs, two Dx approaches: Abacavir ('98 approved), HLA*B5701, on-label rec'd screening for hypersens. #Tricon
6:23pm February 20th 2017 via Hootsuite
Mata: Obdivo compl. Dx; test is PMA approved, doesn't appear any of their labels. Keytruda comp. Dx; 1st line NSCLC PDL1+ #Tricon
6:22pm February 20th 2017 via Hootsuite
Mata: 3 drugs are 2 for chronic hep C by HCP genotype tests. And Exondys 51, anti-sense oligo for Duchenne's MD, a rare disease #Tricon
6:20pm February 20th 2017 via Hootsuite
Mata: And Rubraca (rucaparib) for ov ca based on BRCA1/2. First approval ofNGS as a CDx 'but not necessarily first approval for NGS' #Tricon
6:19pm February 20th 2017 via Hootsuite
Mata: '16 PMC report: 6 approved. 3 oncology; out of total 4 new oncology drugs for 2016. One PD-L1 CDx; CLL by 17p deletion; #Tricon
6:18pm February 20th 2017 via Hootsuite
Mata: Nucala for asthma based on eosinophil ct. Found population that responded. high-enough to respond, a regular Dx not CDx #Tricon
6:17pm February 20th 2017 via Hootsuite
Mata: Others - Daklinza for chronic hep C based on genotype 3 biomarker status; Orkambi for CF based on F508del/CFTR #Tricon
6:16pm February 20th 2017 via Hootsuite
Mata: '15 PMC annual report: 13 newly approved indications. 5 oncology, ALK, BRAF 'nothing novel!' Of the 8: schiz (2) on CYP2D6 #Tricon
6:15pm February 20th 2017 via Hootsuite
Mata: Complementary Dx - biomarker-defined set of pts, not on the label of the drug #Tricon
6:14pm February 20th 2017 via Hootsuite
Mata: Starts w/definitions: Dx, for disease, injury or medical condition. CDx: 'essential for safe and effective use for a drug' #Tricon
Marielena Mata (GlaxoSmithKline) Precision medicine beyond oncology #Tricon Starts w/ a cartoon
6:12pm February 20th 2017 via Hootsuite
Best: From 4 samples, showed good correlation between lancet blood drop and 6mL EDTA draws. #Tricon
6:04pm February 20th 2017 via Hootsuite
Best: Forr glioma: able to distinguish between lower and higher grades; showed heat-maps. Now trying method on blood drops (lancet) #Tricon
Best: Applying to early Br ca, Stg I-III pts, n=89. Able to get 70% spec at near 100% sensitivity (optimized for sens) #Tricon
6:02pm February 20th 2017 via Hootsuite
Best: Able to get 83% accuracy, with AUC 0.89 ROC. 1246-gene panel, can remove 40% non-responders for treatment. #Tricon
6:01pm February 20th 2017 via Hootsuite
Best: Applied SWARM-enhanced thromboseq method to Stg IV Nivolumab anti-PD1 response prediction. RECIST criteria. #Tricon
5:59pm February 20th 2017 via Hootsuite
