Liachko #AGBT19 Shows result from their tool ProxiMeta, of a population that lives in varnish. Novel and known geno… https://t.co/4aHAJCztRN
11:23am March 1st 2019 via Twitter Web Client
Liachko #AGBT19 Hi-C is on every member in population, can scaffold every one of them. And plasmids come along with bacterial data.
11:19am March 1st 2019 via Twitter Web Client
Liachko #AGBT19 Hi-C on mixed populations. Intra and inter chr connections. Proximity keeps phages with host genome… https://t.co/UDIRb24AWc
11:18am March 1st 2019 via Twitter Web Client
Liachko #AGBT19 Developed a method with PacBio called FALCON-Phase combining techniques, adding Hi-C with long read… https://t.co/HA2yepQALJ
11:16am March 1st 2019 via Twitter Web Client
Liachko #AGBT19 Hi-C shown to scaffold chromosomes. Shown many papers. Goat genome '17 Nature Gen https://t.co/5sSuEdyQyh
11:15am March 1st 2019 via Twitter Web Client
Liachko #AGBT19 Reads -> contigs -> genomes confounded: by many genomes in metagenomics. '06 rev https://t.co/YUIAbAEqtW
11:14am March 1st 2019 via Twitter Web Client
Ivan Liachko (Phase Genomics) #AGBT19 “Linking the resistome to the microbiome: A culture-free method to link plasm… https://t.co/7GD0Hr7DXn
11:11am March 1st 2019 via Twitter Web Client
Haerty #AGBT19 Short reads are good for splicing quantification. Estimation of ratios, ID of tissue-enriched splicing patterns.
10:09am March 1st 2019 via Twitter Web Client
Haerty #AGBT19 In disease - DMD (exon deletion), LMA etc. '16 Rev https://t.co/b4M85trbmp Voltage-gated calcium cha… https://t.co/sk9gJho6K0
10:07am March 1st 2019 via Twitter Web Client
Haerty #AGBT19 "You need to be careful when you talk about splicing." Gencode v27 - 19.8 protein coding genes, 80.9… https://t.co/Qxe5RdxFB4
10:05am March 1st 2019 via Twitter Web Client
Wilfried Haerty (Earlham Inst) #AGBT19 “Characterization of splicing diversity and gene fusions through Nanopore sequencing”
10:04am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Chinese are still an issue. Q: Bureaucracy? A: Yes. Price to visit space: $80M
10:01am March 1st 2019 via Twitter Web Client
Q: Will the Russians come with us to Mars? Charles #AGBT19 Lunar orbiting station, yes will work with them, so like… https://t.co/eOmiMKwVL0
10:00am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Points to this NASA roadmap. https://t.co/jNN5QAH274
Charles #AGBT19 Now after the summary Science paper is almost published, a river of follow-on studies will now get… https://t.co/XfDo1jWKqx
9:59am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Biochemical, DNA/RNA/methylation, proteomic, immune, telomeres, metabolomic, microbiome, cognition, vasculatore
9:57am March 1st 2019 via Twitter Web Client
Charles #AGBT19 He was not in favor of this project. And then put in charge of it. Credits Graham Scott (former Lif… https://t.co/YkKqOXBkMz
9:57am March 1st 2019 via Hootsuite Inc.
Charles #AGBT19 Scott and Mike Kelly were both selected as astronauts. All equally assignable. The brothers themselves hinted at it.
9:55am March 1st 2019 via Twitter Web Client
Charles #AGBT19 N=1 study isn't ideal. But Mike Snyder's work '12 Cell https://t.co/QGiX8yHa4y
9:54am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Photo of the astronauts. https://t.co/anMddvZ5Ou
9:53am March 1st 2019 via Hootsuite Inc.
Charles #AGBT19 Russians had done many 1-year missions in the late '80's. Valeri Polyakov did 14 months in '94. Gap… https://t.co/4gfbYN9EYb
9:52am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Can implement prophylaxis, hypothesized, and tested with Scott Kelly with six-month package of coun… https://t.co/4E86u0aI8n
9:51am March 1st 2019 via Twitter Web Client
Charles #aaGBT19 Time to get to steady state. https://t.co/Ql8HYnTvfa
9:49am March 1st 2019 via Hootsuite Inc.
Charles #AGBT19 Plan now: to stage from the moon or near it. Use the moon to refuel. Shows human physiology cycle changes
9:48am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Timing the launch - 30 day window, next window is 18 months away. another 6 months to get to Mars and 6 mo to get back.
9:46am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Shows a view of Earth from the Mars rover Curiosity in 2014: a tiny dot. 180m km (112m miles) away.… https://t.co/swLdsKu1FA
9:44am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Risk 4: Distance from Earth. Huge distances involved, alignment. Plot distance - from 4e8 to 1e10 in km.
Charles #AGBT19 And performance and behavioral health decrements - inadequate cooperation, coordination, communicat… https://t.co/2HnCD8vZxL
9:42am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Isolation / confinement: unlike any that humans have faced before. 2.5years with two others. Cognit… https://t.co/f3dwSpG70L
Charles #AGBT19 Lack of gravity a health problem - long list of adverse health effects. Risk 3: Hostile closed envi… https://t.co/rLLQw1dK0J
9:41am March 1st 2019 via Twitter Web Client
Charles #AGBT19 The predominant risk is radiation; protection from shielding and scheduling. Risk 2: altered gravit… https://t.co/ScyNphJkwH
9:40am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Assuming survival: what about medical risks? Human research: about 3 dozen assignable risks. Hazard… https://t.co/VffLr4BWvJ
9:38am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Riskiest parts - 5 miles/sec in 10 minutes (from 0). And then bring the kinetic energy to stop (re-… https://t.co/t2mPGbmLrq
9:37am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Risks values by duration. https://t.co/rHYxZg2eaf
9:36am March 1st 2019 via Hootsuite Inc.
Charles #AGBT19 'Beyond Earth orbit' is code for going to Mars. Shows ISS with a Mars vehicle - components needd. Est mean risk values.
9:35am March 1st 2019 via Twitter Web Client
Charles #AGBT19 Worked with Chris Mason 5y on the twins study. Photo - only coincidental because Scott was assigned… https://t.co/pnKBgcw0xa
9:34am March 1st 2019 via Twitter Web Client
John Charles NASA Johnson Space Center (retired) #AGBT19 “From here to Mars: How the Twins Study and the year-long… https://t.co/K4dy7cjprM
9:32am March 1st 2019 via Twitter Web Client
Q: TADs can't explain tissue-specificity. Bickmore #AGBT19 TADs have 'disturbed me' due to their conservation.
9:31am March 1st 2019 via Twitter Web Client
Q: Why care about TADs? Bickmore #AGBT19 They are conserved, some kind of polymer maintenance mechanism. Keeping things stable over time.
9:29am March 1st 2019 via Twitter Web Client
Q: Can the domains that initiate phase separation be disrupted? Bickmore #AGBT19 Want to interrupt but not prevent… https://t.co/T42OlKy1GG
Bickmore #AGBT19 Phase separation does not require chr looping, direct contact. 'We lack tools to disrupt, modify p… https://t.co/nVYZ4ZAOhh
9:27am March 1st 2019 via Twitter Web Client
Bickmore #AGBT19 Post-transl mod of protein using PARPI catalytic activity, driving phase separation. '17 Cell… https://t.co/tLVtKub4gz
9:25am March 1st 2019 via Twitter Web Client
RT @mason_lab: Dozens of enhancer-opathies known that influence or cause Mendelian diseases: a great list from Dr. Wendy Bickmore from @Edi…
9:22am March 1st 2019 via Hootsuite Inc.
RT @DCGenomics: Nothing in biology is as simple as we once thought! #agbt19 https://t.co/Uq5Lc2tTfq
Bickmore #AGBT19 Decreased enh-promoter activity during neuronal activation ex-vivo - going apart instead of coming… https://t.co/8MlVMr8DKG
9:21am March 1st 2019 via Twitter Web Client
Bickmore #AGBT19 Mice are fine, no phenotype whatsoever. Prior correlation - no evidence that Shh TAD req'd for correct long-range gene reg.
9:20am March 1st 2019 via Twitter Web Client
Bickmore #AGBT19 Breaking the TAD: mutating the borders of CTCF sites using CRISPR. Shows no disruption of looping… https://t.co/fbs8iE4wZQ
9:19am March 1st 2019 via Twitter Web Client
Bickmore #AGBT19 Used 5C - anterior vs posterior sites: look identical in triangle pattern. Using FISH: probes over… https://t.co/dUv0iXAJqQ
9:16am March 1st 2019 via Twitter Web Client
Bickmore #AGBT19 all GOF muts; it makes the enh too good. Adding one additional binding site to the enhancer. 3D or… https://t.co/qXtMqoc5WT
9:14am March 1st 2019 via Twitter Web Client
Bickmore #AGBT19 Shh locus is an exemplar for long-range gene reg; shows several examples of preaxial polydactyly (… https://t.co/Q101NyypAH
9:13am March 1st 2019 via Twitter Web Client
