Problem - a virus infected his cells, can't use them. New batch to prepare in the next week for infusion later #CancerFilm
10:33pm April 1st 2015 via Twitter Web Client
Back at Rosenberg's lab - over 1B cells given back, he looks at his own cells before transfusion. He handles T-175 flask #CancerFilm
10:31pm April 1st 2015 via Twitter Web Client
Enrolled in new trial - 'if it didn't work we only probably had a few weeks with her'. #CancerFilm
10:30pm April 1st 2015 via Twitter Web Client
Clinical trial in leukemia pts. 6yo girl Emily: full relapse, <30% survival. Mother: "Very few survived w/that mutation." #CancerFilm
10:29pm April 1st 2015 via Twitter Web Client
But a novel approach may expand it: genetically engineer immune cells. Redirecting T-cells to home into cancer. UPenn work #CancerFilm
10:28pm April 1st 2015 via Twitter Web Client
Exciting about these drugs, unlike Rosenberg's, could be given at any cancer clinic. Mainly effective for melanoma & kidney #CancerFilm
10:27pm April 1st 2015 via Twitter Web Client
'96 Allison developed a compound; Yervoy came to market. And several other drugs along the same principle to follow #CancerFilm
10:26pm April 1st 2015 via Twitter Web Client
Early 80's - Allison at MD Anderson told 'it would stall his career'. His idea - not stimulated, but removing restraints #CancerFilm
10:24pm April 1st 2015 via Twitter Web Client
A mole on a patient's leg, too over the body. Isolated immune cells from a removed tumor. Dissected, put into culture, 4 weeks #CancerFilm
10:23pm April 1st 2015 via Twitter Web Client
'Most of whom have exhausted every other treatment'. (Note - melanoma is a tough, tough disease.) #CancerFilm
10:20pm April 1st 2015 via Twitter Web Client
Cancer-fighting T-cells taken out, strengthened, and given back to the same patient. Several melanoma clinical trials #CancerFilm
Rosenberg: "In a tiny percentage of patients, the cancer disappeared" Immune cells educated to attack the cancer #CancerFilm
10:19pm April 1st 2015 via Twitter Web Client
Rosenberg: Isolated various types, and progress 'painfully slow', first 66 patients no progress. But 67th: 30y later still well #CancerFilm
10:18pm April 1st 2015 via Twitter Web Client
RT @theNCI: NCI's Dr. Steven Rosenberg studies immunotherapy for advanced cancers: http://t.co/tuJaUeg3CD #CancerFilm #ImmunoOnc http://t.c…
Steven Rosenberg's effort on immune cells, I blogged about it here: http://t.co/af2vpieKPw #Cancerfilm
10:17pm April 1st 2015 via Twitter Web Client
Coley's could not be replicated, and fell out of favor. Immunotherapy 'remained a backwater, but a few kept the field alive" #CancerFilm
10:16pm April 1st 2015 via Twitter Web Client
And that weapon - the human immune system. Wiliam Coley - early 20th century, a compound of infectious bacteria. Some cured. #CancerFilm
10:15pm April 1st 2015 via Twitter Web Client
"Imagine capturing billions of years of evolution in a single cell" That's cancer - a billion times the speed of evolution #CancerFilm
10:13pm April 1st 2015 via Twitter Web Client
But combination therapies still must battle cancer's complexity. "Think of cancer as 'evolution in a bottle'" #CancerFilm
Cost of sequencing plummet - possible to personalize a combination of drugs. "Just like an infection." #CancerFilm
10:12pm April 1st 2015 via Twitter Web Client
Vogelstein "200 genes funnel down into about 12 pathways" A pathway: like a 'bucket brigade' (Golub) Multiple places to disrupt #CancerFilm
10:11pm April 1st 2015 via Twitter Web Client
Again multi-drug therapies - catalog mutations, and find vulnerabilities. (Lander) 'A way to deploy your armies' #CancerFilm
10:10pm April 1st 2015 via Twitter Web Client
RT @aicrtweets: Obesity increases risk for 10 cancers, our infographic.http://t.co/w3xV44yoWt #cancerfilm http://t.co/cPitEQRJaH
10:09pm April 1st 2015 via Twitter Web Client
Trend of patterns within the cancer cell - not all mutations equally significant. Most are random. Just a few key ones (Lander) #CancerFilm
10:08pm April 1st 2015 via Twitter Web Client
With BRCA mutation - 70% br ca, 30% ovarian. Collins: family history, environmental, and DNA. Prevention on the individ. #CancerFilm
10:07pm April 1st 2015 via Twitter Web Client
Mary Claire King - discovered hereditary breast cancer gene BRCA1/2 by looking at familial breast cancer (mastectomy study) #CancerFilm
10:05pm April 1st 2015 via Twitter Web Client
Markers can be in the form of mutations. Fun seeing an autogradiogram of DNA sequence being read out. Nostalgia! #CancerFilm
10:03pm April 1st 2015 via Twitter Web Client
Men not spared either, with the PSA test and its false-positives. Bishop: consequences of being wrong 'devastating' #CancerFilm
10:02pm April 1st 2015 via Twitter Web Client
Mammogram false positives result in disfiguring, needless surgery. 'Ethically and economically difficult to stop' #CancerFilm
10:01pm April 1st 2015 via Twitter Web Client
At MD Anderson - the mammogram hailed as a breakthrough, the test becomes part of an annual checkup. But controversial #CancerFilm
10:00pm April 1st 2015 via Twitter Web Client
And early prevention another tool; cure via surgery. Colon cancer screening popularized; colon ca down 10% #CancerFilm
9:59pm April 1st 2015 via Twitter Web Client
Vogelstein: "Cancer rates can be reduced 50% if we simply implement all we already know about prevention" #CancerFilm
9:58pm April 1st 2015 via Twitter Web Client
But vaccines, like against HPV, if children can get an immunization. 'That's amazing - to wipe out cervical cancer' #CancerFilm
9:57pm April 1st 2015 via Twitter Web Client
Cancer clusters - numbers are small, some potential point source may have disappeared. But an old suspect again: viruses #CancerFilm
9:55pm April 1st 2015 via Twitter Web Client
Epidemiologists struggle to understand 'the behavior of cancers' - why sometimes like infectious disease; other times geography #CancerFilm
9:54pm April 1st 2015 via Twitter Web Client
Causative mutations likely due to copying errors; but what are the hidden triggers of those 40%? So much speculation. #CancerFilm
9:51pm April 1st 2015 via Twitter Web Client
If trends continue w/obesity epidemic - 'soon we'll have to face square on'. But other causes - some 40% still unknown #CancerFilm
9:50pm April 1st 2015 via Twitter Web Client
Another preventable epidemic - obesity 'clearly higher risk of colon, breast and other cancers' #CancerFilm
9:49pm April 1st 2015 via Twitter Web Client
Jan 1971 - the last ad on TV; timeline of bans (airplanes, indoor, bars, workplaces). Decline by 1/2; lung ca trends down too #CancerFilm
9:48pm April 1st 2015 via Twitter Web Client
A letter to FCC: equal time to anti-smoking along with cigarette ads in late 1960's 'Your total consumption: 1/2 Million' #CancerFilm
9:47pm April 1st 2015 via Twitter Web Client
In 1964 to 67: smoking increased after the SG's warning. Idea - turning TV ads against cigarette mfr's #CancerFilm
9:45pm April 1st 2015 via Twitter Web Client
Stopping smoking - 'vastly more effect on cancer mortality than what I can do in my lifetime (as a cancer researcher)' #CancerFilm
9:44pm April 1st 2015 via Twitter Web Client
Harold Varmus (outgoing head of NCI) in 2010 - a call for a shift, to cancer prevention. 'We overlook it b/c it isn't exciting' #CancerFilm
9:43pm April 1st 2015 via Twitter Web Client
"Everyone has a different idea of what a good death looks like." "Healing is sometimes helping people have a good death." (tears)#CancerFilm
9:42pm April 1st 2015 via Twitter Web Client
"I want you to be stronger so you can go home. And then decide on more treatment." (then hugs the patient) #CancerFilm
'You have to make a choice to have more treatment, or do you want to stop?' Patient weeps. "I see the time coming..." #CancerFilm
9:40pm April 1st 2015 via Twitter Web Client
Palliative care is new. Started by Cicely Saunders ('67). Some treat it as a war; others use language of negotiation. #CancerFilm
9:39pm April 1st 2015 via Twitter Web Client
Patient says: "Oh this really sucks." The understatement of the entire film, being informed of a poor prognosis. :( #CancerFilm
9:36pm April 1st 2015 via Twitter Web Client
"Why should we as physicians have all the information about the patient? Shouldn't they have it as well?" #CancerFilm
9:34pm April 1st 2015 via Twitter Web Client
"I know many of my patients with Stage IV disease will die." #CancerFilm
9:32pm April 1st 2015 via Twitter Web Client
