From 10's of thousands of genes, how to find the cancer-causing gene? Sprinkling genes one at a time, to find the one. #CancerFilm
9:59pm March 31st 2015 via Twitter Web Client
"If you turn up enough stones, you'll find something." (Weinberg caught in a Boston snowstorm, walking out of a cave of shadows) #CancerFilm
9:58pm March 31st 2015 via Twitter Web Client
Late '70's - a worldwide hunt for the human oncogene. 'Science is a profession for manic/depressives' (Weinberg) #CancerFilm
9:57pm March 31st 2015 via Twitter Web Client
'Now a glimpse of cancer's cause' - genes for growth, a single explanation 'the oncogene'. It won Varmus/Bishop the Nobel. #CancerFilm
9:56pm March 31st 2015 via Twitter Web Client
Ducks, emus, 'and by fiddling with the technology, we 'found it in humans'. Genes causing cancer 'already in animal genomes' #CancerFilm
9:55pm March 31st 2015 via Twitter Web Client
src almost superfluous - why is there? Orig. in the chicken? "It was a riveting moment" (Bishop) to find it in chicken. #CancerFilm
9:54pm March 31st 2015 via Twitter Web Client
RSV has only 4 genes. Simplified problem 'immensely'. gag, pol, env, src. What is src? Extra gene causes gene 'oncogene' #CancerFilm
9:53pm March 31st 2015 via Twitter Web Client
Molecular biology was developing; instruments to peer inside the cells (thanks @appliedbio!) and find mechanism of disease #CancerFilm
9:52pm March 31st 2015 via Twitter Web Client
Harold Varmus 'I studied English Lit more than science'; Bishop worked with him, studied Rous Sarcoma Virus (RSV). #CancerFilm
9:51pm March 31st 2015 via Twitter Web Client
Ames: genes being mutated >was< the relationship between viruses and chemicals. A grand unified theory of cancer. #CancerFilm
9:50pm March 31st 2015 via Twitter Web Client
1967 - Bruce Ames made a 'momentous discovery'; 'we ought to have an easy test to see if they are mutagens'. #CancerFilm
9:49pm March 31st 2015 via Twitter Web Client
'Cancer is a disease of the genome goes back to the beginning of the 20th century' (Lander) #CancerFilm
9:48pm March 31st 2015 via Twitter Web Client
What do viruses and chemicals have in common? Could it be genes? There were clues... 'largely ignored' (Bishop) #CancerFilm
9:47pm March 31st 2015 via Twitter Web Client
"And to solve it, we need to solve the most difficult problem of all - the nature of life itself" #CancerFilm
9:46pm March 31st 2015 via Twitter Web Client
RT @CancerCenter: Smoking causes lung cancer and so much more. #CancerFilm http://t.co/L3AjKsnCr0
RT @sloan_kettering: Today, tobacco use causes 87% of lung cancer deaths in men and 70% in women, via @AmericanCancer #CancerFilm http://t.…
9:42pm March 31st 2015 via Twitter Web Client
Pair of studies came to the same concl.; cigarette co's said 'complex and still obscure' 'other factors' 'keep an open mind' #CancerFilm
9:41pm March 31st 2015 via Twitter Web Client
RT @ACSLubbock: By 1945 lung cancer comprised 20% of all cancers. #CancerFilm
9:40pm March 31st 2015 via Twitter Web Client
Hill and Dahl asked 100's of Q's - and 1 Q on smoking. And only one link to cancer - cigarettes. #CancerFilm
9:38pm March 31st 2015 via Twitter Web Client
But viruses not the singular cause. Then: a chemical one. 1775 - Percival Pott noticed scrotal cancer in chimney sweeps #CancerFilm
9:35pm March 31st 2015 via Twitter Web Client
RT @TCGAupdates: Check out the Rous paper on "Sarcoma of the Common Fowl" http://t.co/N4lCebE365 #Cancerfilm #openaccess
9:33pm March 31st 2015 via Twitter Web Client
Epstein-Barr virus first one linked to human cancer. Terrifying to public, and cancer vaccine worked on in early '70's #CancerFilm
9:32pm March 31st 2015 via Twitter Web Client
Harold Varmus (@theNCI) - hard to push experiments past the Rous experiments. Abdominal tumors in Africa, Burkitt's #CancerFilm
9:31pm March 31st 2015 via Twitter Web Client
1908: Payton Rous, tested by a LI chicken tumor. ID'd as a virus. 1 pg paper 'and all hell broke loose' (Bishop narrates) #CancerFilm
9:29pm March 31st 2015 via Twitter Web Client
Long believed: a single cause and a single cure. But disagreed onto the cause: Viruses. Chemicals. Genes. All silo-ed. #CancerFilm
9:27pm March 31st 2015 via Twitter Web Client
A Howard Univ MD Laurie Wilson diagnosed with cancer herself; two different types; one TNBC :( Hard to watch. #CancerFilm
9:24pm March 31st 2015 via Twitter Web Client
Fisher overthrew central dogma "cutting more meant curing more"; treatment w/o understanding mechanism causes damage #CancerFilm
9:19pm March 31st 2015 via Twitter Web Client
1985: the results released. 'No significant difference' - whether you 'amputated the whole breast' or not, 'it was the same' #CancerFilm
9:18pm March 31st 2015 via Twitter Web Client
Yet patients themselves (the women) found out there was an alternative. Science journalist Rose Kushner to the rescue. #CancerFilm
9:17pm March 31st 2015 via Twitter Web Client
He was tough: "In God we trust; all others must bring data". Thought to be a traitor. Denied funding, couldn't recruit pts #CancerFilm
9:16pm March 31st 2015 via Twitter Web Client
And doing a randomized trial - 'totally antithetical to theirs'; 'the most hated surgeon in history' #CancerFilm
9:15pm March 31st 2015 via Twitter Web Client
Credits Bernard Fisher to look at the biology - a 'systemic disease', since spread was via lymph nodes. The lumpectomy born. #CancerFilm
9:14pm March 31st 2015 via Twitter Web Client
40K radical mastectomies every year; biopsy/surgery performed 'within minutes' of each other. #CancerFilm
9:12pm March 31st 2015 via Twitter Web Client
In the '70's: Breast cancer leading cause of death among women. Same Rx: Halsted's radical mastectomy, for decades #CancerFilm
9:11pm March 31st 2015 via Twitter Web Client
Great to see Eric Lander (@broadinstitute) - 'This is nothing like going to the moon' #CancerFilm
9:09pm March 31st 2015 via Twitter Web Client
"There's nothing more horrifying... than cancer. It's us killing ourselves." #CancerFilm
9:05pm March 31st 2015 via Twitter Web Client
Last night's #Cancerfilm had 5,465 participants & 17.5K tweets. Last year's #AACR14 in 3d had 5.4K & 20K respectively (over 4 days!)
9:01pm March 31st 2015 via Twitter Web Client
RT @HopkinsMedicine: Again, we are excited to be live tweeting tonight during part two of @CancerFilm. Join the conversation using #CancerF…
8:57pm March 31st 2015 via Twitter Web Client
RT @foxggf: RT @Berci: First Ever 3D Printed Thyroid Gland Announced by Russia’s 3D Bioprinting Solutions http://t.co/aXhiqZfgRu http://t.c…
1:30pm March 31st 2015 via Twitter Web Client
RT @lizworthey: JH: 10% cores no longer offer sanger, 67% offer Illumina NGS 23% offer ion torrent. > 40% cores offer Bioinformatics serv
1:28pm March 31st 2015 via Twitter Web Client
RT @pinfoto: MT ~3.2 tweets /user @tmlfox: Day one tweet activity by minute for #CancerFilm. With 5,465 unique participants. #hcsm http://t…
11:11am March 31st 2015 via Twitter Web Client
RT @nygenome: First LDT from NYGC cleared for clinical diagnostic use! @HealthNYGov approves NYGC clinical whole exome #sequencing: http://…
7:19am March 31st 2015 via Twitter Web Client
RT @theNCI: Have you scrolled thru our interactive "250 Years of Advances against Cancer"? http://t.co/DT5KOIhBAA #CancerFilm http://t.co/…
10:56pm March 30th 2015 via Twitter Web Client
RT @NIH: Mary Lasker, sometimes called 1st lady of medical research, played pivotal role for #NIH. Here’s how http://t.co/uti2Brf7uM #Cance…
10:24pm March 30th 2015 via Twitter Web Client
RT @mason_lab: #ABRF2015 Absolute Intrinsic Molecular Subtyping (AIMS) from single cell RNA-seq can reveal subtype by Jiannis Ragoussis fro…
4:51pm March 29th 2015 via Twitter Web Client
RT @mason_lab: #ABRF2015 400bp reads on Proton1 chip, and if you take three P1 chips, you can get a 30X genome. Isothermal-seq on PGM enabl…
RT @thinkDNA: In case you missed it: newborn whole genome sequencing? really? This is what we think: http://t.co/oIovIYajhh
3:52pm March 29th 2015 via Twitter Web Client
.@DaffodilPlanter @DCSWA Agreed - thanks for a great #DCSWA15 professional development day. Many great #scicomm insights and take-aways.
4:59pm March 28th 2015 via Twitter Web Client in reply to DaffodilPlanter
Q: What's the most rewarding thing? A:JM:"Finishing it" KS: Seeing things take shape MS: Seeing the book on the shelf #dcswa15 #scicomm
4:56pm March 28th 2015 via Twitter Web Client
MC: Example of R Skloot - traveling cross-country on her own dime. But quality of the book itself is paramount #dcswa15 #scicomm
4:54pm March 28th 2015 via Twitter Web Client
