Edwards: #BHCRForum18 Started drug disc, crystal structure solved 10y ago. All parties agree to public domain. $3.5M raised.
9:02am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 Going after inoperable diffuse intrinsic pontine glioma; fatal, mut in H27M histone H3, some ALK2 kinase (ACVR1)
9:01am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 M4K is owned by arm's length Charitable Trust, committed to making meds affordable
Edwards: #BHCRForum18 Restriction of M4K is 'use of pre-clin and clin data for reg filings, preserving exclusive marketing rights'
9:00am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 To disc, develop affordable medicines for rare childhood cancers. Patents enable sharing.
8:59am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 Orphan drugs may extend another 2y; EU 10+, CAN 8y, JP 8y. Started M4K pharma to coord https://t.co/OkOsCht1vF
8:58am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 Another way to protect your market: the regulatory pathway. 20y patent may only have 5y of data exclusivity
8:56am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 Deciding to do drug disc 'in the open', taking it all the way to market. Lists criticisms: $, how to protect?
8:55am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 Pharma donated probe program - eLife ref '18 https://t.co/LDs1Urf4zY pre-competitive sharing
8:54am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 Points to this commentary '09 ref https://t.co/O2Eq0MLEYl (Ironic: Nature Chem Bio is paywalled.)
8:51am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 Open data, open publishing, materials and knowledge avail w/o restriction to anyone. 'No deals', no pref access
8:50am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 'Open science is the most efficient' - started in '04; Wellcome, Gates Found. 'SGC scientists never file patents'
8:49am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 Inefficiencies - "25 cents or less returned for every dollar spent". Drug disc - illustr. cost of this.
8:48am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 Ranking from Global vs Canadian science in '16: look identical. Working on the same kinases...
8:45am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18 Medicines are not affordable; 'redundancy is a signif. cause'. 500 kinases; shown ranked by popularity
8:44am April 24th 2018 via Twitter Web Client
Edwards: #BHCRForum18>$250B is invested yearly in biomed res. We still don't even understand molecular mechanisms, let alone Rx strategy
8:43am April 24th 2018 via Twitter Web Client
Aled Edwards (Structural Genomics Consortium Univ Toronto CA) Creating companies from an open science ecosystem #BHCRForum18
8:41am April 24th 2018 via Twitter Web Client
Glad to be here at #BHCRForum18 for a second day. Agenda here: https://t.co/JbdnT5oKVo Crab Trap startup competition later
8:39am April 24th 2018 via Twitter Web Client
#BHCRForum18 John Trainer: VP MedImmune. What's needed for a great biohealth cluser? Need 3 things: great science, leaders & capital
4:27pm April 23rd 2018 via Twitter Web Client
Copan: #BHCRForum18 ROI initiative: getting better returns from $150B in federal spending. https://t.co/hExo9nEVYZ
4:21pm April 23rd 2018 via Twitter Web Client
Copan: #BHCRForum18 Genetic testing via @GenomeInABottle https://t.co/EOmQfHn1bL 100 members, multiple tech's. Also cell authentication
4:18pm April 23rd 2018 via Twitter Web Client
Copan: #BHCRForum18 Work with cardiac device makers, digital temp logging w/NIST traceability https://t.co/BngdJzTX8s
4:17pm April 23rd 2018 via Twitter Web Client
Copan: #BHCRForum18 Magneto-encephalography (MEG) 'squid' devices 1/100th the size/power PR https://t.co/sLdsUbs1cT
4:15pm April 23rd 2018 via Twitter Web Client
Copan: #BHCRForum18 MRI standard - 'phantom' breast cancer imaging PR https://t.co/CkIaSfruXz
4:14pm April 23rd 2018 via Twitter Web Client
Copan: #BHCRForum18 Link to NISTmAb product: https://t.co/ZIbAqZqZx5 Imaging: MRI has different formats
Copan: #BHCRForum18 53 pharma, device and research insts acquired reference monoclonal NISTmAb in 3 mos
4:12pm April 23rd 2018 via Twitter Web Client
Copan: #BHCRForum18 Adv mfg in Gburg MD, quantum science in Boulder CO. Provides 1200+ std ref materials (SRMs) Bio… https://t.co/XQknD9drCz
Copan: #BHCRForum18 Atomic clock - updated in '14 https://t.co/jckjXBAf2l and checked 8B times/day. 3400 empl.
4:10pm April 23rd 2018 via Twitter Web Client
Copan: #BHCRForum18 NIST has a footprint in 'every state of the union'. Mission: to enhance economic security, quality of life
4:05pm April 23rd 2018 via Twitter Web Client
Walter Copan #BHCRForum18 Measurements, standards, and innovation for better health care
4:04pm April 23rd 2018 via Twitter Web Client
Q: Sole founder, thoughts? #BHCRForum18 Thomas: Doesn't matter to them (INOVA). Vogelstein: A Q of the team, though. 20 co's: all groups
3:34pm April 23rd 2018 via Twitter Web Client
#BHCRForum18 Vogelstein: Strength: on quantum computing (NSA, UMD).
3:31pm April 23rd 2018 via Twitter Web Client
#BHCRForum18 Vogelstein: Harder may be 'higher-tech', machine learning for example (hard anywhere). Easier on WC. CRISPR expertise also
Q: Co's start here and move elsewhere? #BHCRForum18 Vogelstein: Lots of talent pools here. Paragon, PGDx can find people
3:30pm April 23rd 2018 via Twitter Web Client
Otey: Clearer paths to market etc. Make technologies 'more investible', of critical importance #BHCRForum18
3:22pm April 23rd 2018 via Twitter Web Client
Otey: here 'nobody knew each other' unlike Boston, where scientists' wheels (are fully in motion). #BHCRForum18 Product: grants-focus
3:21pm April 23rd 2018 via Twitter Web Client
Q: What can Capital area do? #BHCRForum18 Otey: Hasn't seen acquisition in this area with large knock-on effects (Cubist example)
3:20pm April 23rd 2018 via Twitter Web Client
Present: Clearly an appetite #BHCRForum18 And I-O, how to invest beyond large pharma. Too much money at the wrong time...
3:11pm April 23rd 2018 via Twitter Web Client
Otey: Gov't may clamp down on Asia money inflow #BHCRForum18 But need clin success from IND to approval
3:10pm April 23rd 2018 via Twitter Web Client
Jones: Influx of capital from Asia? #BHCRForum18 Otey: Seen a 4y trend, many sectors along w/life sciences. Seen deals dep on it
Thomas: Brevity for investors is valued. #BHCRForum18 Easy to understand, to lead to add'l conversations
2:48pm April 23rd 2018 via Twitter Web Client
Plumaker: investment arm of HC2 Holdings #BHCRForum18 Thomas: from INOVA - late-stage, very early stage taking risk.
2:47pm April 23rd 2018 via Twitter Web Client
#BHCRForum18 Panelists C Plumaker (Pansend), D Present (Panned Life Sci), M Thomas (INOVA), C Otey (Alexandria RE),… https://t.co/m9SZxsIBNo
2:37pm April 23rd 2018 via Twitter Web Client
Next #BHCRForum18 Panel: Investors with a local presence. #BHCRForum18 Andy Jones (TEDCO) moderator
2:36pm April 23rd 2018 via Twitter Web Client
Q: Criteria? #BHCRForum18 Silber: Intelligence, health, vision, passion, willingness to embrace change and pivot if need be
2:31pm April 23rd 2018 via Twitter Web Client
Q: Low impact high prob? Converse? #BHCRForum18 Aberman: Everyone invests based on their own tradeoffs.
Galvin: Technologists may or may not be good entrepreneurs. Looking for technologists who are also visionaries #BHCRForum18 Jobs vs Wozniak
2:20pm April 23rd 2018 via Twitter Web Client
Q: How to rescue a deal going sideways? #BHCRForum18 Klein: Goes to data, why. If only opinions, just an argument Y… https://t.co/6cNOY8LZ58
2:19pm April 23rd 2018 via Twitter Web Client
Klein: Control that comes through influence. If the CEO is 'king'... Silber: Can they listen to what the market says? #BHCRForum18
2:14pm April 23rd 2018 via Twitter Web Client
Silber: If he wanted control, he would just start another company. #BHCRForum18 Success/failure goes to the entrepreneur
2:13pm April 23rd 2018 via Twitter Web Client
